ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Best Supplements for Cortisol Reduction: A Scientific Guide

Cortisol-Reducing Supplements: What Works?

TL;DR

Adaptogens like Ashwagandha and Rhodiola, along with Phosphatidylserine, are effective in reducing cortisol levels, supported by scientific studies.

Managing stress levels and reducing cortisol, the stress hormone, are critical for maintaining overall health and well-being. Key ingredients found in stress management supplements, such as adaptogens Ashwagandha and Rhodiola, as well as Phosphatidylserine, have been scientifically supported for their cortisol-lowering effects. Studies have shown that participants using Ashwagandha experienced a significant reduction in cortisol levels. Similarly, Phosphatidylserine supplementation has been associated with a 20-50% reduction in cortisol levels post-exercise. This guide delves into the mechanisms of these ingredients, their effectiveness, recommended dosages, and potential side effects, providing a comprehensive overview for individuals interested in stress management and cortisol reduction.
By John Williams, Sports Medicine & Performance NutritionOctober 2, 202513 min read

Which Ingredients Effectively Reduce Cortisol?

Adaptogens like Ashwagandha and Rhodiola, along with Phosphatidylserine, are effective at reducing cortisol levels.

Adaptogens like Ashwagandha and Rhodiola, plus Phosphatidylserine, stand out for their ability to effectively reduce cortisol levels. This is critical because high cortisol levels are linked to stress, and managing these levels can help improve your overall stress response and wellbeing.

Ashwagandha, a well-known adaptogen, has been studied extensively for its stress-reducing properties. Research indicates that taking 300mg of Ashwagandha extract twice daily can significantly lower cortisol levels, sometimes by as much as 27.9% over a 60-day period. This herb works by regulating the stress response systems in the body, making it easier for you to manage stress physically and mentally.

Rhodiola is another adaptogen with a strong track record for lowering cortisol and enhancing stress resilience. A study found that participants taking 400mg of Rhodiola extract daily experienced improved stress symptoms and fatigue reduction within just 4 weeks. Rhodiola functions by inhibiting the activity of enzymes that break down serotonin and dopamine, thus improving mood and stress resistance.

Phosphatidylserine, a phospholipid found in cell membranes, plays a pivotal role in modulating cortisol responses, especially after exercise. It's been observed that doses ranging from 300mg to 800mg per day can help reduce exercise-induced stress and cortisol levels. The mechanism behind this is Phosphatidylserine's ability to protect brain cells and facilitate communication between them, which in turn helps manage the body's stress response more efficiently.

However, it's important to understand that these supplements might not work the same way for everyone. Factors like individual stress levels, lifestyle, and overall health can influence how effective these supplements are. For instance, if your stress is due to an underlying health condition, these supplements might not be as effective unless that condition is addressed.

The significance of managing cortisol levels can't be overstated. Elevated cortisol over long periods can lead to numerous health issues, including weight gain, high blood pressure, and disrupted sleep. Thus, incorporating these supplements into your routine, along with a healthy lifestyle, can have a profound impact on your ability to manage stress and improve your overall health.

When looking for supplements, quality and dosage are key. This is where platforms like the ProveIt app come in handy, allowing you to compare brands and check for third-party testing verification to ensure you're getting a product that's both safe and effective. Remember, while supplements can help manage cortisol levels, they're most effective when used in conjunction with a balanced diet, regular exercise, and good sleep hygiene.

  • Ashwagandha: Significant cortisol reduction in clinical studies
  • Rhodiola: Improves stress response and reduces fatigue
  • Phosphatidylserine: Modulates cortisol response, especially post-exercise

How Do These Ingredients Work to Reduce Cortisol?

These ingredients modulate the body's stress response and cortisol production through various mechanisms.

Adaptogens like Ashwagandha and Rhodiola, along with compounds such as Phosphatidylserine, are at the forefront of naturally managing stress and reducing cortisol levels. These ingredients work by influencing the body’s hormonal balance and stress response mechanisms in distinct ways. Understanding how they function can empower you to make informed decisions about managing stress and cortisol levels effectively.

Ashwagandha has been heralded for its ability to lower cortisol levels significantly. Clinical evidence suggests that Ashwagandha works by modulating the stress response pathways in the brain, effectively telling the adrenal glands to produce less cortisol. A study found that taking 600mg of Ashwagandha daily led to a substantial reduction in cortisol levels among participants, highlighting its potency and effectiveness.

Rhodiola operates slightly differently. It enhances the body's resistance to stress by influencing key neurotransmitters, including serotonin and dopamine, which play critical roles in mood regulation. This adaptogen helps to stabilize the stress-response system, thereby reducing the production of cortisol. Research supports its use, with findings indicating that doses ranging from 400mg to 600mg daily can significantly improve stress symptoms and fatigue.

Phosphatidylserine stands out for its unique action on the body’s cortisol response, particularly after exercise. It’s shown that supplementing with 600mg of Phosphatidylserine daily can help attenuate the increase in cortisol levels post-exercise, promoting better recovery and reducing the physical stress on the body. This is crucial for athletes or anyone engaged in regular physical activity, as managing cortisol levels can significantly impact performance and recovery.

Why does this matter? Elevated cortisol levels over time can lead to a host of health issues, including poor sleep quality, weight gain, and increased risk for chronic diseases. Integrating these supplements into your routine, in the correct dosages, offers a natural strategy to maintain balanced cortisol levels, enhancing overall health and wellbeing.

However, it's essential to note that while these supplements can be effective, they're part of a broader stress management strategy that includes lifestyle and dietary adjustments. And when it comes to finding high-quality supplements, sifting through the options can be overwhelming. Platforms like the ProveIt app can simplify this process by helping you compare brands and verify the quality of supplements, ensuring you’re choosing a product that's both safe and effective.

In conclusion, adaptogens and specific compounds offer promising benefits for reducing cortisol and managing stress, backed by scientific research. By understanding how they work and incorporating them into a balanced approach to health, you can take proactive steps toward improving your stress resilience and overall quality of life.

  • Ashwagandha: Regulates chemical signaling in the nervous system
  • Rhodiola: Enhances the body's ability to manage stress
  • Phosphatidylserine: Impacts the stress-induced activation of the hypothalamic-pituitary-adrenal axis

What Scientific Studies Support Their Effectiveness?

Numerous studies have validated the cortisol-reducing effects of Ashwagandha, Rhodiola, and Phosphatidylserine.

Ashwagandha, Rhodiola, and Phosphatidylserine stand out for their cortisol-reducing capabilities, backed by solid scientific research. These natural compounds are not just folk remedies but have been scrutinized in rigorous clinical settings to verify their stress-reducing and cortisol-lowering effects. Let's dive into what the science tells us about each of these powerful ingredients.

Starting with Ashwagandha, a 2020 study involving 60 participants demonstrated that taking 240 mg of Ashwagandha daily led to a significant reduction in stress levels and cortisol compared to a placebo. This adaptogen works by regulating chemical signaling in the nervous system, thereby reducing the perception of stress and lowering cortisol levels – a critical factor for anyone looking to manage stress and its physical consequences.

Rhodiola Rosea, another adaptogen, has been the focus of numerous studies for its fatigue-reducing and anti-stress effects. One pivotal study showed that participants experiencing stress-related fatigue who took 400 mg of Rhodiola daily for four weeks reported significantly reduced cortisol levels upon waking. Unlike stimulants that offer a temporary energy boost followed by a crash, Rhodiola supports sustained energy and focus by balancing the body's stress response system.

Phosphatidylserine, a phospholipid found in cell membranes, plays a unique role in modulating the body's response to stress, especially related to exercise. Research including a 2007 study on exercise-induced stress revealed that athletes who supplemented with 600 mg of Phosphatidylserine daily for 10 days had lower cortisol levels and perceived less stress after intense workouts. This effect is particularly valuable for athletes seeking to optimize recovery and performance by managing their stress hormone levels effectively.

It's important to note that while these supplements are beneficial for reducing cortisol and managing stress, their effectiveness can vary based on dosage and individual differences. For Ashwagandha, dosages between 240 mg to 600 mg daily have been effective, while Rhodiola's benefits are seen with dosages around 400 mg. Phosphatidylserine's cortisol-reducing effects are noted at higher dosages, around 600 mg per day.

In the crowded world of supplements, it can be tough to find products that deliver on their promises. That's where comparing brands for quality and efficacy becomes crucial. For those navigating the options, the ProveIt app can be a handy tool for checking supplement quality and ensuring you're getting a product that aligns with the clinical evidence.

Remember, when it comes to managing stress and cortisol levels, the combination of lifestyle changes, diet, and the right supplementation can make all the difference. These scientifically supported ingredients are a testament to the power of natural compounds in enhancing our well-being.

  • Ashwagandha: Participants showed significant cortisol level reduction
  • Rhodiola: Studies indicate improved stress response and fatigue reduction
  • Phosphatidylserine: Associated with 20-50% cortisol reduction post-exercise

Are There Any Side Effects?

While generally safe, potential side effects and interactions should be reviewed.

When it comes to managing stress and lowering cortisol levels, adaptogens like Ashwagandha and Rhodiola, as well as supplements such as Phosphatidylserine, are generally safe for most people. But, like any substance that has physiological effects, they come with potential side effects and interactions, particularly when taken in incorrect dosages or alongside certain medications.

Ashwagandha is well-supported by scientific research for its stress-reducing effects. A study involving 64 subjects revealed a significant reduction in stress levels with doses of 300 mg twice daily over a 60-day period. However, some users report mild side effects such as drowsiness, gastrointestinal discomfort, and, in rare cases, allergic reactions. It’s also advised to use caution if you're taking medication for diabetes or have thyroid conditions since Ashwagandha can interact with these conditions.

Rhodiola is another adaptogen with a strong evidence base for lowering cortisol and combatting fatigue. Clinical evidence suggests optimal benefits at dosages ranging from 400 to 600 mg per day. Side effects are uncommon but can include dizziness and dry mouth for some individuals. Given Rhodiola's energizing effects, taking it late in the day might interfere with sleep patterns for some.

Phosphatidylserine plays a role in modulating the body's response to stress, especially related to exercise, by affecting cortisol levels. Studies indicate that doses up to 600 mg per day can help attenuate symptoms of stress. However, phosphatidylserine sourced from soy may not be suitable for individuals with soy allergies or sensitivities.

Safe and effective dosages are crucial for maximizing the benefits of these supplements while minimizing potential risks. For Ashwagandha, a daily dose of up to 600 mg is supported by research for stress reduction without significant side effects. Rhodiola's sweet spot appears to be around 400 to 600 mg daily, and for Phosphatidylserine, doses up to 600 mg are considered safe and effective, particularly in reducing exercise-induced stress and cortisol levels.

If you're considering adding any of these supplements to your regimen, it's important to be mindful of how they might interact with existing conditions or medications. Checking a supplement's quality and purity through a reliable source like the ProveIt app can also help ensure you're getting what you expect without unwanted additives or contaminants. Remember, while these supplements have a good safety profile, individual responses can vary, and consulting with a healthcare provider before starting new supplements is always a smart move.

  • Ashwagandha: Generally well-tolerated; rare side effects include gastrointestinal discomfort
  • Rhodiola: Possible mild side effects like dizziness or dry mouth
  • Phosphatidylserine: Mostly safe; some reports of insomnia and stomach upset

What Is the Recommended Dosage for Cortisol Reduction?

Safe and effective dosages vary, with clinical evidence supporting specific ranges for each ingredient.

When it comes to reducing cortisol, specific dosages of certain supplements have been clinically supported to be both safe and effective. Adaptogens like Ashwagandha and Rhodiola, as well as compounds like Phosphatidylserine, are at the forefront of this, each with its own recommended dosage range derived from scientific studies.

Ashwagandha, a well-researched adaptogen, has been shown to significantly lower cortisol levels and reduce stress. The effective dosage typically ranges from 300 to 500 mg per day, taken in divided doses. A 2020 study involving 60 participants found that 300 mg of Ashwagandha taken twice daily led to a considerable reduction in stress and cortisol levels compared to a placebo.

Rhodiola is another adaptogen with robust evidence supporting its role in cortisol reduction, especially in situations involving fatigue and stress. Clinical trials suggest an optimal dosage between 200 and 600 mg daily. A 12-week study with participants experiencing chronic fatigue symptoms reported marked improvements in stress symptoms, fatigue, and overall quality of life when taking 400 mg of Rhodiola daily.

Phosphatidylserine, known for its cognitive benefits, also plays a significant role in modulating the body’s cortisol response, particularly after physical activity. Research indicates a dosage range of 300 to 800 mg per day to be effective. Specifically, a study demonstrated that athletes consuming 600 mg of Phosphatidylserine daily experienced a more pronounced decrease in cortisol levels post-exercise, compared to those who did not supplement with it.

Why does this matter? High cortisol levels, if left unchecked, can lead to a plethora of health issues, including chronic stress, weight gain, and disrupted sleep patterns. By adhering to the recommended dosages of these supplements, individuals can effectively manage their cortisol levels, thereby mitigating these risks.

It's important to note, though, that these supplements might not work for everyone in the same way. Factors like individual health conditions, current medication, and overall lifestyle can influence their effectiveness. Plus, quality matters. With the supplement market being as vast as it is, finding high-quality products is critical. For those looking to track the quality and efficacy of their supplements, tools like the ProveIt app can be a valuable resource for comparing brands and ensuring the supplements you choose meet stringent quality standards.

  • Ashwagandha: 300-500 mg daily
  • Rhodiola: 200-600 mg daily
  • Phosphatidylserine: 100-300 mg daily

How Do These Ingredients Compare in Effectiveness?

Effectiveness varies, with some ingredients having more robust support than others.

When comparing the effectiveness of cortisol-reducing ingredients, it's clear that some have stronger scientific backing than others. Adaptogens like Ashwagandha and Rhodiola rosea, along with Phosphatidylserine, stand out for their ability to manage cortisol levels, but the devil is in the details of how they work and the specific dosages needed.

Ashwagandha has gained considerable attention for its stress-reducing powers. A study involving 60 individuals over 60 days highlighted a significant reduction in stress levels among those taking 600mg of Ashwagandha daily, compared to a placebo group. This adaptogen works by regulating the body's stress response via the adrenal glands, signaling them to produce less cortisol when it's not needed.

Rhodiola rosea, another adaptogen, boasts similar stress-relief benefits. Research indicates that taking 400mg per day can enhance your body's stress resistance, making stressful situations feel less overwhelming. Rhodiola works by stimulating serotonin and dopamine activity, neurotransmitters involved in mood regulation and stress response.

On the other hand, Phosphatidylserine, a phospholipid found in cell membranes, has a slightly different approach to managing cortisol. It's been shown to blunt the cortisol response after exercise, with studies recommending doses between 300-800mg to achieve this effect. This is significant because excessive cortisol post-exercise can hamper recovery and muscle growth.

However, it's important to note that while these supplements are effective, they don't all work in the same way or at the same speed. Ashwagandha and Rhodiola primarily modulate the stress response systemically, making them more versatile for daily stress management. In contrast, Phosphatidylserine's benefits are particularly pronounced in the context of physical stress and recovery, making it a favorite among athletes and those with a high physical workload.

Moreover, the effectiveness of these supplements can vary based on individual factors such as baseline stress levels, lifestyle, and even genetic predispositions to stress. Therefore, while the outlined dosages are backed by research, finding the "sweet spot" can require some personal experimentation.

This nuanced understanding is crucial because it helps set realistic expectations. For someone looking to manage daily stress, Ashwagandha or Rhodiola might be more beneficial, while someone focusing on athletic performance and recovery might lean towards Phosphatidylserine. Remember, it's always a good idea to check the quality and exact dosage of these supplements. Platforms like the ProveIt app can be incredibly helpful in comparing brands and ensuring you're getting a product that's as effective as the research suggests.

In conclusion, while Ashwagandha, Rhodiola, and Phosphatidylserine all offer promising benefits for reducing cortisol and managing stress, their specific applications and effectiveness can vary. Understanding these differences is key to choosing the right supplement for your needs.

Comparison of Cortisol-Reducing Ingredient Effectiveness
IngredientCortisol ReductionStudy Findings
AshwagandhaSignificant ReductionHighly supported by clinical trials
RhodiolaModerate ReductionSupported by several studies
Phosphatidylserine20-50% Reduction Post-ExerciseSupported by exercise-related studies

References

  1. FDA Dietary Supplement Ingredient Advisory List (government, 2023) - View Source(article)
  2. National Center for Complementary and Integrative Health (NCCIH) – Herbs at a Glance (government, 2023) - View Source(article)
  3. The Role of Adaptogens in Stress Management (academic, 2022) - View Source(article)
  4. Effects of Phosphatidylserine on Cortisol Responses to Acute Exercise Stress (academic, 2021) - View Source(article)
  5. Herbal and Dietary Supplements for Treatment of Anxiety Disorders (academic, 2020) - View Source(article)
  6. Comparative effects of several stress management supplements on indices of stress and anxiety (academic, 2020) - View Source(article)

About the Author

John Williams
John Williams

Sports Medicine & Performance Nutrition

Sports medicine physician and performance nutrition expert specializing in supplement protocols for athletic performance, recovery, and injury prevention. Works with professional and collegiate athletes to optimize their nutrition. Passionate about evidence-based approaches to sports nutrition and supplementation.

View all articles by John →

More from John

Top Ingredients for Healthy Weight Management

ingredients

Dietary fiber, protein, omega-3 fatty acids, and water are crucial for managing a healthy weight.

October 2, 202515 min read

Top Immune Support Ingredients: What Works?

effectiveness

Vitamin D, zinc, and echinacea are key ingredients in immune support supplements, backed by scientific evidence.

October 2, 202513 min read

Top Anti-Inflammatory Supplement Ingredients

ingredients

Curcumin, omega-3 fatty acids, CBD, and Vitamin D are proven to effectively reduce chronic inflammation.

October 2, 202511 min read

Optimal BCAA Ratios for Muscle Recovery

effectiveness

The optimal BCAA ratio for muscle recovery and growth is 2:1:1 (leucine:isoleucine:valine), enhancing protein synthesis and reducing soreness.

October 2, 202511 min read

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice. Always consult with a healthcare provider before making changes to your supplement routine or if you have specific health concerns.