5a Hydroxy Laxogenin Acetate
Also known as: 5-Alpha-Hydroxy-Laxogenin, 5-Laxogenin, 5α-Hydroxy-laxogenin
Overview
5α-Hydroxy-laxogenin is a synthetic derivative of laxogenin, categorized as a spirostane-type steroid. It is marketed as an anabolic agent in dietary supplements, primarily for muscle growth and strength enhancement. Despite its claims, research supporting its efficacy is sparse and often lacks rigorous clinical designs. Most studies investigating this compound are in vitro, indicating the potential to interact with the androgen receptor, albeit with considerable uncertainty about its effects in humans. Furthermore, it is not a naturally occurring compound, which raises concerns regarding its classification as a plant-based anabolic agent. The current research is labeled as low quality, lacking systematic reviews or substantial clinical evidence.
Benefits
The evidence supporting the benefits of 5α-Hydroxy-laxogenin in humans is limited and primarily based on in vitro studies suggesting potential androgenic activity. Claims of increased protein synthesis and nitrogen retention are made by some manufacturers, but reliable peer-reviewed evidence confirming these effects in humans is lacking. No specific populations have been identified that would benefit significantly from its use. Consequently, effect sizes and clinical significance remain undetermined due to insufficient high-quality research.
How it works
5α-Hydroxy-laxogenin may exert its effects via interaction with the androgen receptor, which plays a critical role in muscle growth and protein synthesis. However, the exact molecular mechanisms and pathways it influences are still unclear due to a lack of in vivo studies. As it is not fully understood how this compound interacts with the body, the biological pathways involved require further exploration.
Side effects
The safety profile of 5α-Hydroxy-laxogenin remains uncertain because of the absence of human trials. There are currently no documented common side effects in scientific literature, nor are there findings on uncommon or rare side effects. Due to the lack of comprehensive data, no drug interactions or contraindications have been established. The FDA has classified the compound as unlawful in dietary supplements, which raises additional safety concerns. Special population considerations, such as for pregnant or breastfeeding women, are not addressed due to insufficient information.
Dosage
There is no established dosing regimen for 5α-Hydroxy-laxogenin due to the lack of human study protocols. Consequently, recommendations for minimum effective doses, optimal dosage ranges, and maximum safe doses are not available. No specific timing considerations exist, and no form-specific recommendations or factors affecting absorption have been identified. Without peer-reviewed evidence, any claimed dosing practices must be approached with caution.
FAQs
Is 5α-Hydroxy-laxogenin safe to use?
The safety of 5α-Hydroxy-laxogenin is unclear due to the absence of human studies, and it is considered unlawful in dietary supplements by the FDA.
What benefits does 5α-Hydroxy-laxogenin provide?
While some in vitro studies suggest potential androgenic effects, there is no reliable evidence to support any specific benefits in humans.
How should 5α-Hydroxy-laxogenin be taken?
No specific guidance is available on timing or administration, and due to unclear safety, use is not recommended.
Are there any common side effects?
Currently, there are no documented common side effects associated with the use of 5α-Hydroxy-laxogenin in peer-reviewed literature.
Is 5α-Hydroxy-laxogenin a natural product?
No, 5α-Hydroxy-laxogenin is a synthetic derivative of laxogenin and is not derived from natural sources.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/35344071/ – This study presents in vitro evidence of the androgen activity of 5α-Hydroxy-laxogenin. However, no human trials have confirmed these findings.
- https://www.researchgate.net/publication/340673588_Analysis_of_Ingredients_of_Supplements_in_the_National_Institutes_of_Health_Supplement_Database_Marketed_as_Containing_a_Novel_Alternative_to_Anabolic_Steroids – This research analyzes the ingredients in dietary supplements, identifying 5α-Hydroxy-laxogenin among those marketed as steroid alternatives, with a note on the necessity for further investigation.
- https://www.usada.org/spirit-of-sport/illegal-ingredient-5-alpha-hydroxy-laxogenin-supplements/ – This resource outlines the classification of 5α-Hydroxy-laxogenin as an unlawful substance according to FDA regulations, emphasizing the risks involved.
- https://www.webmd.com/vitamins/ai/ingredientmono-1567/laxogenin – WebMD discusses laxogenin and its derivatives, including their marketed benefits and the legal status of 5α-Hydroxy-laxogenin.
- https://www.biospace.com/hi-tech-doubles-production-of-laxogenin-100-a-revolutionary-bodybuilding-anabolic-agent – This article details advancements in the production of laxogenin, elaborating on claims made by manufacturers regarding its anabolic potential while questioning the validity of such claims.
