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Achyranthes Bidentata Extract

Also known as: Chinese niu xi, ox knee, *Achyranthes bidentata* Blume, Achyranthes bidentata

Overview

*Achyranthes bidentata* is a herbal extract primarily sourced from the roots of the plant, widely utilized in traditional Chinese medicine for enhancing bone health and alleviating joint-related ailments, particularly osteoporosis and osteoarthritis. The extract has gained attention for its potential to increase bone mineral density (BMD) and exert anti-inflammatory effects. Current research on *Achyranthes bidentata* includes several animal studies demonstrating promising results, as well as some human clinical trials; however, the quality of evidence varies, necessitating further rigorous trials to solidify its safety and efficacy in human populations. The extract is predominantly available in powdered form or as liquid extracts, both of which retain the active phytochemicals thought to confer health benefits.

Benefits

*Achyranthes bidentata* root extract (ABBRE) is associated with multiple evidence-backed benefits. The extract has been shown to increase bone mineral density significantly in osteoporotic rat models, evidenced by a standardized mean difference (SMD) of 1.64 in a meta-analysis. This suggests a strong potential for osteoporosis management. Additionally, *Achyranthes bidentata* may possess anti-inflammatory and immune-regulatory properties beneficial for conditions such as osteoarthritis. While the focus has been largely on animal studies, preliminary human observations indicate potential benefits for postmenopausal women with osteoporosis. However, the results in human trials are still inconclusive, underscoring the need for further investigations to confirm the benefits observed in animal models.

How it works

The mechanisms through which *Achyranthes bidentata* exerts its effects include inhibition of bone resorption and enhancement of bone formation, primarily through modulation of biological pathways involving cytokines such as TNF and IL-6 for osteoarthritis and possibly utilizing the MAPK cascade in osteoporosis treatments. Active compounds like quercetin and baicalein have been identified, indicating the extract's role in inflammation modulation. Additionally, despite its promising effects on bone health and inflammation, the precise absorption and bioavailability in humans remain under-researched.

Side effects

The safety profile of *Achyranthes bidentata* is generally considered favorable based on its traditional usage; however, comprehensive clinical safety data are limited. Adverse effects are not well-documented in current literature, and no significant common or rare side effects have been identified in peer-reviewed studies. Due to the absence of formal trials in specific populations, pregnant or breastfeeding women are advised to seek medical advice before consumption. As there is inadequate information on potential drug interactions, caution is recommended for those on concurrent medications. There are no widely recognized contraindications, but individual responses may vary.

Dosage

Dosage recommendations for *Achyranthes bidentata* remain uncertain due to the lack of established effective doses in humans. Animal studies indicate doses of up to 400 mg/kg/day, suggesting a baseline for potential human dosing, although no direct translation can be made. Continuous administration over several weeks is recommended to elicit observable benefits. The extract is typically taken in root extract form, but more concrete guidelines for optimal and safe human dosages are necessary. Upper limits and safety thresholds have not been defined, emphasizing the need for cautious, informed use.

FAQs

What should I consider before using *Achyranthes bidentata*?

Always consult a healthcare provider prior to use, especially if you have osteoporosis or osteoarthritis.

Is it safe to use *Achyranthes bidentata*?

While traditionally used and generally considered safe, comprehensive human safety data is lacking.

How long should I take it to see results?

Continuous use over several weeks may be necessary; consult a healthcare provider for specific recommendations.

What results can I expect?

It may support bone health, but further clinical research is needed for confirmation.

Is it a proven treatment for osteoporosis or osteoarthritis?

Current evidence supports potential effects, but clinical validation is still required.

Research Sources

  • https://pubmed.ncbi.nlm.nih.gov/39363520/ – This meta-analysis reviewed 11 studies involving 222 animals to evaluate the effects of *Achyranthes bidentata* on bone mineral density, finding significant increases in BMD among osteoporotic rats, thus highlighting the extract's potential for osteoporosis management.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC11457373/ – The network pharmacology study explored therapeutic mechanisms associated with *Achyranthes bidentata*, identifying several bioactive constituents that influence MAPK pathways, suggesting avenues for potential osteoporosis treatments.
  • https://pubmed.ncbi.nlm.nih.gov/37849727/ – This article provides insights into the pharmacological actions of *Achyranthes bidentata* and its effects on inflammatory pathways, suggesting its therapeutic potential for various inflammatory conditions.
  • https://colab.ws/articles/10.1080%2F13880209.2024.2407531 – The review focuses on in vitro investigations and theoretical models showcasing the extract's active compounds and their potential roles in treating bone and joint ailments.