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Achyranthes Root Extract

Also known as: Achyranthes, Ox Knee, Chinese Knotweed, *Achyranthes bidentata*

Overview

*Achyranthes bidentata* is a medicinal plant predominantly found in Asia, used within traditional medicine practices for its potential benefits in bone health, especially in treating osteoporosis. The root extract of *Achyranthes bidentata* (ABBRE) has garnered attention for its osteoprotective properties, primarily observed through animal studies that demonstrate increases in bone mineral density (BMD). Despite the promising findings in preclinical research, there is a scarcity of human clinical trials to substantiate these effects. The current body of literature indicates moderate research maturity with ongoing investigations, supported by an increasing number of systematic reviews and meta-analyses tailored to understand its efficacy. The primary forms of the supplement are through root extracts, which are traditionally used in various herbal formulations.

Benefits

ABBRE is recognized for its primary effect in increasing bone mineral density (BMD) in osteoporotic animal models, particularly with a significant standardized mean difference (SMD) of 1.64 (95% CI = 0.52 to 2.77). This suggests that ABBRE may hold promise for osteoporosis management, particularly when doses do not exceed 400 mg/kg/day over a treatment duration of 12 weeks. Other potential benefits, though less documented, include anti-inflammatory and antioxidant effects, which could further enhance overall health. However, human clinical trials are necessary to confirm these benefits and establish their significance across diverse populations.

How it works

The mechanism of action of ABBRE primarily involves the inhibition of bone resorption and enhancement of bone formation, which collectively contribute to increased bone mass. It interacts with the skeletal system by affecting bone metabolism; however, specific molecular targets are not well defined in existing literature. The precise absorption and bioavailability of ABBRE in humans remains largely unknown, necessitating further research to elucidate these aspects.

Side effects

Overall, ABBRE is considered safe based on traditional usage; however, comprehensive human safety data is lacking. Common and uncommon side effects are not well documented, which complicates an understanding of its safety profile. Rare side effects have also not been reported in the scientific literature. Potential drug interactions remain largely unexplored, and while no established contraindications exist, caution is advised, especially for pregnant or breastfeeding women, who should seek medical consultation due to insufficient safety data. Any individuals with underlying health concerns are similarly encouraged to consult healthcare providers before using this supplement.

Dosage

The minimum effective dose of ABBRE is not firmly established for humans; current animal studies have utilized dosages at or below 400 mg/kg/day. There are no determined optimal dosage ranges for human populations at this time, and maximum safe doses remain undefined. Timing for consumption has not yet been specified either. Typically, ABBRE is utilized in the form of root extracts, but factors related to absorption and required cofactors are currently unknown, indicating a clear need for structured human dosing studies to provide concrete guidelines.

FAQs

Is Achyranthes safe to use?

While traditionally used safely, comprehensive human safety data is lacking; consult a healthcare provider before use.

What benefits does Achyranthes provide?

It may help increase bone mineral density and offers potential anti-inflammatory effects, but human studies are necessary.

What dosage of Achyranthes should I take?

Dosage for humans is not firmly established; studies suggest up to 400 mg/kg/day in animals, but more research is needed.

Can Achyranthes interact with medications?

Potential drug interactions are not well studied; caution is advised, particularly for those on other medications.

Does Achyranthes treat osteoporosis effectively?

Initial animal studies suggest potential benefits, but definitive human clinical trials are required for proof.

Research Sources

  • https://pubmed.ncbi.nlm.nih.gov/39363520/ – This meta-analysis reviewed effects of ABBRE on bone health, demonstrating increased BMD in osteoporotic models, but highlights the need for human studies.
  • https://www.science.gov/topicpages/m/medicine+salacia+oblonga – A systematic review emphasizing the therapeutic effects of ABBRE for osteoporosis, acknowledging the limited human clinical trial data.
  • https://colab.ws/articles/10.1080%2F13880209.2024.2407531 – Preclinical studies indicate the mechanisms through which ABBRE inhibits bone resorption and promotes formation, yet lack human data.
  • https://www.science.gov/topicpages/m/medicine+unani – This resource compiles traditional uses and pharmacological effects of various herbal medicines, including ABBRE's role in skeletal health.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC11457373/ – Discusses potential health benefits of various herbal supplements, situating ABBRE within the context of bone health and traditional practices.

Supplements Containing Achyranthes Root Extract

UriVArx by Innovus Pharmaceuticals
55

UriVArx

Innovus Pharmaceuticals

Score: 55/100
Blood Stimulator TCM Concentrate by Nature's Sunshine
58

Blood Stimulator TCM Concentrate

Nature's Sunshine

Score: 58/100
HY-C TCM Concentrate by Nature's Sunshine
70

HY-C TCM Concentrate

Nature's Sunshine

Score: 70/100
KB-C TCM Concentrate by Nature's Sunshine
58

KB-C TCM Concentrate

Nature's Sunshine

Score: 58/100
Trigger Immune TCM Concentrate by Nature's Sunshine
60

Trigger Immune TCM Concentrate

Nature's Sunshine

Score: 60/100
UriVArx by Innovus Pharmaceuticals
55

UriVArx

Innovus Pharmaceuticals

Score: 55/100
Blood Stimulator by Nature's Sunshine
53

Blood Stimulator

Nature's Sunshine

Score: 53/100