Advanced Sleep Formula Proprietary Blend
Also known as: Sleep aid blends, Natural sleep supplements, Non-sedative sleep formulas, Advanced Sleep Formula Proprietary Blend
Overview
Advanced Sleep Formula Proprietary Blend is a complex formulation designed to improve sleep quality and onset. It combines natural botanicals such as *Eschscholzia californica* (California poppy) and hops (*Humulus lupulus*) with amino acids like glycine, taurine, and L-tryptophan. It also includes neurotransmitter precursors like GABA and L-theanine, minerals such as magnesium and zinc, vitamin B6, and tart cherry fruit extract. The blend aims to support endogenous melatonin production and natural circadian rhythms, making it a non-habit-forming alternative for individuals experiencing insomnia, particularly women and older adults. While individual ingredients have varying levels of evidence, research specifically evaluating the proprietary blend as a whole is limited. The quality of evidence is stronger for components like melatonin, magnesium, and glycine, but less robust for complex blends without isolated testing. These blends are designed to improve sleep onset, reduce nighttime awakenings, enhance deep and restorative sleep phases, and support overall sleep quality.
Benefits
The blend aims to reduce sleep latency, with melatonin supplementation shown to reduce it by approximately 7-12 minutes. Magnesium and glycine supplementation may improve subjective sleep quality and sleep efficiency. Tart cherry extract has demonstrated modest increases in total sleep time and sleep efficiency in small trials. Ingredients like L-theanine and GABA may promote relaxation and reduce anxiety, indirectly benefiting sleep. Vitamin B6 supports neurotransmitter synthesis, potentially enhancing sleep regulation. Women, particularly during menopause, may benefit from nutritional interventions targeting sleep disturbances. Older adults often experience improved sleep quality with magnesium and melatonin supplementation. Melatonin and benzodiazepine receptor agonists show moderate effect sizes in reducing sleep latency and improving sleep parameters, while other ingredients show smaller or inconsistent effects. Melatonin effects are typically acute, noticeable within days to weeks, while minerals and amino acids may require longer supplementation (weeks) for effects.
How it works
The blend works through multiple biological pathways. Melatonin acts on MT1 and MT2 receptors to regulate circadian rhythms and promote sleep onset. Magnesium modulates NMDA receptors and GABAergic activity, promoting muscle relaxation and calming the nervous system. Glycine acts as an inhibitory neurotransmitter, lowering core body temperature and facilitating sleep. GABA and L-theanine enhance inhibitory neurotransmission and reduce neuronal excitability. These ingredients modulate the central nervous system via neurotransmitter pathways and regulate circadian rhythms via pineal gland melatonin secretion. Melatonin is rapidly absorbed orally, with peak plasma levels within 60 minutes. Magnesium bioavailability varies by salt form, with amino acid chelates having higher absorption. Glycine and other amino acids are well absorbed in the gut.
Side effects
The Advanced Sleep Formula Proprietary Blend is generally well-tolerated when used at recommended doses, with a low risk of dependency compared to pharmaceutical hypnotics. Common side effects include mild gastrointestinal discomfort from magnesium and daytime drowsiness or headache from melatonin. Uncommon side effects include dizziness and vivid dreams from melatonin. Rare side effects include allergic reactions to botanical components. Melatonin may interact with anticoagulants, immunosuppressants, and diabetes medications, while magnesium can interfere with the absorption of some antibiotics. Caution is advised during pregnancy and breastfeeding, and individuals with autoimmune diseases should use melatonin with caution. Older adults may require lower doses, and children should use melatonin only under medical supervision.
Dosage
The minimum effective dose for individual components includes 0.3 to 1 mg of melatonin for sleep onset, 200-400 mg of elemental magnesium, and 3 g of glycine before bedtime. Optimal dosage ranges include 1-5 mg of melatonin, 200-400 mg of magnesium, and 500-750 mg of GABA. The maximum safe dose is up to 10 mg of melatonin short-term and up to 350 mg of elemental magnesium from supplements daily. Melatonin and amino acids should be taken 30-60 minutes before bedtime. Chelated minerals are recommended for better absorption. Avoid taking magnesium with high-dose calcium or certain antibiotics. Vitamin B6 enhances magnesium and tryptophan metabolism.
FAQs
Is the proprietary blend safe for long-term use?
Melatonin should not be used indefinitely without medical advice; other ingredients are generally safe with proper dosing.
Will it cause morning grogginess?
Low-dose melatonin and non-sedative ingredients minimize this risk.
Can it be combined with other sleep aids?
Caution is advised; consult a healthcare provider to avoid additive sedative effects.
How soon will I see results?
Melatonin effects can be seen within days; other ingredients may take weeks.
Is it habit-forming?
There is no evidence of dependency with these natural ingredients at recommended doses.
Research Sources
- https://us.supersmart.com/en/shop/sleep-problems/advanced-sleep-formula-0756 – This URL provides product information for Advanced Sleep Formula, highlighting its use for sleep problems. It likely contains marketing and general information about the product's intended benefits and ingredients.
- https://academic.oup.com/nutritionreviews/article/82/8/1087/7268827 – This systematic review of 37 studies examined nutritional interventions for menopause-related sleep disturbances. The review found that nutritional supplements, including magnesium, melatonin, and herbal extracts, improved some sleep parameters in the majority of studies, while 22 studies showed no benefit, indicating mixed evidence.
- https://jcsm.aasm.org/doi/10.5664/jcsm.6470 – This meta-analysis of 19 RCTs (n>1000) found that melatonin significantly reduced sleep latency by approximately 7 minutes (effect size ~0.3) and improved subjective sleep quality. The study reported minimal adverse effects, but noted heterogeneity in doses and populations and that most studies were short-term.
- https://www.mdpi.com/2072-6643/13/4/1283 – This URL leads to a study published by MDPI, likely related to nutrition and sleep. Further review of the study would be needed to provide a detailed summary of its findings, but it could potentially offer insights into the effects of specific nutrients or dietary patterns on sleep quality.
- https://junglongevity.com/products/advanced-sleep-repair – This URL provides product information for Advanced Sleep Repair, likely a similar sleep supplement. It may contain marketing and general information about the product's intended benefits and ingredients, but should be considered as a commercial source.
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