Get Your Personalized Supplement StackSupplement Stack Quiz

Advantra Z

Also known as: Bitter Orange, Seville Orange, p-synephrine, para-synephrine, Advantra Z, Citrus aurantium

Overview

Advantra Z®, derived from *Citrus aurantium* (bitter orange), is a standardized extract primarily containing p-synephrine. This compound is a sympathomimetic amine, mimicking the effects of the sympathetic nervous system. It is commonly found in dietary supplements aimed at weight loss, fat reduction, and energy enhancement. p-Synephrine stimulates beta-3 adrenergic receptors, increasing lipolysis and metabolic rate. Research on *Citrus aurantium* extracts is moderate, with clinical trials and systematic reviews available, though a comprehensive meta-analysis is lacking. Evidence quality varies, with well-designed RCTs alongside studies with methodological limitations. Advantra Z® is generally considered safe at recommended dosages, but potential cardiovascular effects warrant caution. It is available in various forms, mainly capsules, and is often combined with other ingredients in weight loss formulations. The extract is sourced from the peel of the bitter orange fruit.

Benefits

Advantra Z®, primarily through its active compound p-synephrine, offers several potential benefits. Studies suggest it can lead to significant weight loss and improvements in body composition. For instance, research indicates that products containing *Citrus aurantium* peel can result in notable weight reduction over several weeks. p-Synephrine has also been shown to increase resting metabolic rate, contributing to greater energy expenditure. Some evidence suggests it may suppress appetite, potentially aiding in calorie control. These benefits are generally observed in healthy adults, but more research is needed to understand its effects in other populations. The clinical significance of these effects can vary depending on the study design and population.

How it works

p-Synephrine, the primary active compound in Advantra Z®, functions as a sympathomimetic amine. It primarily stimulates beta-3 adrenergic receptors, which are involved in the regulation of lipolysis (fat breakdown) and thermogenesis (heat production). This stimulation leads to an increase in metabolic rate and energy expenditure. By interacting with the sympathetic nervous system, p-synephrine influences energy expenditure and fat oxidation. While it primarily targets beta-3 adrenergic receptors, it has minimal impact on alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors. This selective action is thought to contribute to its relatively mild cardiovascular effects compared to other sympathomimetic amines.

Side effects

While generally considered safe at recommended dosages, Advantra Z® can cause side effects, particularly related to its stimulant properties. The most common side effect is an increased heart rate, especially at higher doses or when combined with other stimulants like caffeine. Some individuals may experience changes in blood pressure, although most studies show no significant effects on systolic or diastolic blood pressure when used alone. Rare side effects are not well-documented, but high doses or long-term use could potentially lead to more severe cardiovascular issues. It should be used cautiously with other stimulants due to potential additive effects on heart rate and blood pressure. Individuals with hypertension, cardiovascular disease, or those taking certain medications should consult a physician before use. Pregnant or breastfeeding women, and individuals with certain medical conditions, should avoid use due to lack of safety data.

Dosage

The recommended dosage for Advantra Z® is up to 100 mg of p-synephrine per day, which equates to 200 mg of Advantra Z®. This daily dose should be divided into two or three smaller doses, spaced out by 6 to 8 hours or 4 to 6 hours, respectively, to avoid excessive stimulation. A typical minimum effective dose is around 50 mg of p-synephrine per dose. It is usually available in capsule form, and oral absorption is adequate, although bioavailability can vary. There are no specifically noted required cofactors, but adequate hydration is recommended. It is crucial not to exceed the maximum safe dose of 100 mg of p-synephrine per day.

FAQs

Is Advantra Z® safe?

It is generally safe when used as directed, but caution is advised for individuals with cardiovascular conditions or those taking certain medications. Consult a healthcare professional before use.

How should I take Advantra Z®?

Doses should be spaced out to avoid excessive stimulation. Follow the recommended dosage guidelines and avoid taking it close to bedtime to prevent sleep disturbances.

What results can I expect from taking Advantra Z®?

Potential benefits include weight loss, increased energy expenditure, and potential appetite suppression. However, it is not a substitute for a healthy diet and exercise.

Can I take Advantra Z® with caffeine?

Caution is advised when combining Advantra Z® with caffeine or other stimulants due to the potential for additive effects on heart rate and blood pressure.

Research Sources

https://www.mdpi.com/2072-6643/14/19/4019 – This is a systematic review that examines the effects of Citrus aurantium and its isolated bio-active compounds on various health outcomes. The review notes outcomes such as increased energy expenditure, fat oxidation, and reduced carbohydrate utilization, but a meta-analysis was not performed due to heterogeneity among the included studies.
https://hsls.libguides.com/PubMed-search-filters/systematic-reviews – This resource provides guidance on conducting systematic reviews using PubMed search filters. It offers strategies for identifying relevant studies and synthesizing evidence to address specific research questions, aiding in the creation of comprehensive and reliable reviews.
https://downloads.regulations.gov/FDA-2019-S-0023-0047/content.pdf – This document from the FDA contains information related to supplement regulations and safety. It may include data on specific ingredients, including Citrus aurantium, and their potential risks or benefits, contributing to the overall understanding of supplement safety and efficacy.
https://www.researchgate.net/post/Necessity_of_Embase_Scopus_and_Web_of_Science_as_database_for_systematic_review – This ResearchGate discussion explores the necessity of using Embase, Scopus, and Web of Science databases for systematic reviews. It highlights the importance of comprehensive literature searches to minimize bias and ensure the inclusion of all relevant studies in systematic reviews.
https://www.rivendell.eu/library/documents/diverse%20documenten/kruiden%20divers/Citrus-aurantium_Phytotherapy-Research.pdf – This phytotherapy research document on Citrus aurantium likely contains information on its traditional uses, chemical composition, and pharmacological effects. It may provide insights into the mechanisms of action and potential therapeutic applications of Citrus aurantium extracts, contributing to a better understanding of its health benefits.