Get Your Personalized Supplement StackSupplement Stack Quiz

Advantra Z Bitter Orange Extract

Also known as: Bitter orange, Seville orange, Citrus aurantium

Overview

Bitter orange extract is derived from the immature fruits of *Citrus aurantium* L., primarily containing p-synephrine, a protoalkaloid. It is a widely recognized dietary supplement used for weight loss and metabolic enhancement. The extract is typically standardized to contain a specific percentage of p-synephrine, which ranges from 6% to 50%, depending on the formulation. Research on bitter orange includes numerous human clinical trials, animal studies, and in vitro studies, which largely support its safety and efficacy when used at recommended dosages. This extract is commonly included in various herbal and weight management products, appealing to individuals seeking support in their weight loss journey.

Benefits

Bitter orange extract provides several evidence-based benefits, primarily in weight loss and metabolism. Clinical studies indicate that individuals consuming the extract can experience weight loss of approximately 1-3 kg over 6-12 weeks, with particular efficacy noted in overweight or obese individuals. For instance, research by Colker et al. found significant weight loss (1.4 kg) and a reduction in body fat (2.9%) over six weeks. Additionally, bitter orange extract has been shown to increase resting metabolic rate, contributing to energy expenditure. Importantly, research confirms that it does not significantly alter cardiovascular parameters such as heart rate or blood pressure, suggesting cardiovascular safety when used appropriately.

How it works

The active compound p-synephrine functions as a metabolic enhancer. It binds to adrenergic receptors but has a lower affinity compared to norepinephrine, which accounts for its minimal cardiovascular effects. p-Synephrine increases resting metabolic rate and energy expenditure, aiding in weight loss and fat reduction while avoiding the stimulating effects typically associated with other sympathomimetic compounds.

Side effects

Bitter orange extract is considered safe at recommended doses, receiving Generally Recognized as Safe (GRAS) status. Common side effects (over 5%) may include dry mouth, heightened activity, and sleep disturbances, although these effects are not universally reported. Rarely (under 1%), no severe adverse effects have been documented in relation to p-synephrine. While there are no significant drug interactions noted, caution is recommended when used in conjunction with other stimulants or medications. Individuals with pre-existing cardiovascular conditions or those on specific medications should seek medical advice before use. Pregnant or breastfeeding women should also consult healthcare providers due to potential risks.

Dosage

The typical minimum effective dose of p-synephrine is around 10-20 mg daily, with optimal dosages ranging from 25-50 mg. Some studies have safely used doses up to 50 mg per day for periods of up to 60 days. It is advisable to take the supplement before meals as part of a weight management routine. The extract usually comes in standardized forms that ensure consistent p-synephrine content, enhancing reliability in dosing. Assumptions regarding absorption are that the extract is adequately absorbed when taken orally, though no specific absorption factors were specified in the literature.

FAQs

Is bitter orange extract safe to use?

Yes, bitter orange extract is generally considered safe at recommended doses, but caution is advised for specific populations.

How should I take bitter orange extract?

It is recommended to take the supplement before meals as part of a weight management regimen.

What results can I expect from using bitter orange extract?

Users can expect modest weight loss and increased metabolic rate over several weeks of consistent use.

Does p-synephrine affect the heart like ephedrine?

No, despite structural similarities, p-synephrine does not significantly affect cardiovascular parameters at recommended doses.

Research Sources

https://downloads.regulations.gov/FDA-2020-S-0023-0091/content.pdf – This document provides a comprehensive review of the safety and efficacy profiles of bitter orange extract, highlighting its GRAS status and widespread usage in dietary supplements.
https://www.medsci.org/v09p0527.htm – This study investigates the effects of Citrus aurantium extract on body composition and metabolism, demonstrating its potential benefits for weight management and metabolic enhancement.
https://pubmed.ncbi.nlm.nih.gov/30835576/ – This publication presents a systematic review of the clinical efficacy and safety of p-synephrine, emphasizing its role in weight loss and lack of significant cardiovascular effects.
https://juniperpublishers.com/nfsij/pdf/NFSIJ.MS.ID.555708.pdf – The article discusses the biochemical and physiological effects of bitter orange extract, providing insight into its mechanism and safety profile in nutritional supplementation.
https://www.researchgate.net/publication/363940929_The_Safety_and_Efficacy_of_Citrus_aurantium_Bitter_Orange_Extracts_and_p-Synephrine_A_Systematic_Review_and_Meta-Analysis – This meta-analysis synthesizes findings across multiple studies to assess the overall safety and efficacy of bitter orange extract and p-synephrine, highlighting its benefits for weight loss and metabolism.