Aflapin Boswellia Serrata Extract
Also known as: Aflapin, Indian frankincense, AKBA (acetyl-11-keto-beta-boswellic acid), Boswellia serrata Extract
Overview
Boswellia serrata, commonly known as Indian frankincense, is a tree native to India and the Middle East that produces a fragrant resin traditionally used in Ayurvedic medicine. The Aflapin extract is a standardized formulation of this resin, enriched specifically with the active compound acetyl-11-keto-beta-boswellic acid (AKBA). Aflapin is utilized predominantly for managing chronic inflammatory conditions such as osteoarthritis, rheumatoid arthritis, asthma, and Crohn’s disease. Its formulation is designed to enhance bioavailability and improve therapeutic efficacy. Numerous studies, including randomized controlled trials and systematic reviews, demonstrate the effectiveness of Aflapin in providing cognitive support and pain relief, establishing its significance as a dietary supplement.
Benefits
Aflapin supplementation has shown substantial benefits, particularly for individuals suffering from osteoarthritis. Significant clinical trials report a 45% reduction in Visual Analog Scale (VAS) pain scores and a 44.4% decrease in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scores within five days of treatment, effects maintained for up to 30 days. Additionally, Aflapin lowers inflammatory markers like matrix metalloproteinase-3 (MMP-3) and tumor necrosis factor-alpha (TNFα), showcasing its potent anti-inflammatory properties. High-quality studies support these findings, confirming Aflapin’s ability to enhance physical function and provide effective pain relief, marking it as a valuable therapeutic option for patients with inflammatory joint disorders.
How it works
Aflapin functions by inhibiting inflammatory enzymes, particularly 5-lipoxygenase, which subsequently leads to decreased leukotriene production, critical mediators of inflammation. The extract also reduces levels of inflammatory biomarkers, such as TNFα and high-sensitive C-reactive protein (hsCRP), contributing to an overall reduction in inflammation. By acting upon immune and musculoskeletal pathways through its active component AKBA, Aflapin promotes pain relief in joints and improves functional capabilities.
Side effects
Aflapin is generally recognized as safe, with research indicating minimal adverse effects. Common side effects do not exceed a frequency of 5%, and no rare adverse responses have been documented. However, it is recommended to seek medical advice before using Aflapin with other medications due to potential undetermined interactions. Caution is also advised for pregnant and breastfeeding women due to insufficient studies verifying safety in these populations. The safety and efficacy of Aflapin in children have not been adequately established, warranting supervision by healthcare professionals.
Dosage
The effective dosage of Aflapin typically ranges around 100 mg per day, standardized to contain 20% AKBA. An optimal dosage range of 100 mg to 200 mg daily is advised, with 100 mg serving as a common initial dose. Although no specific upper limit is identified, doses up to 200 mg daily have been well tolerated in clinical trials. Aflapin can be taken once or twice daily, and its absorption is enhanced due to AKBA enrichment, providing flexibility in administration timing.
FAQs
How long does it take to see benefits?
Benefits are typically observed as early as five days of treatment.
Is it safe?
Aflapin is generally considered safe, with no significant adverse effects reported in research studies.
Can it be used with other medications?
It's advisable to consult with a healthcare provider before using Aflapin with other medications.
What are the expected results?
Users can expect significant reductions in pain and improvements in physical function.
Is Aflapin a cure for osteoarthritis?
No, it serves as a symptomatic management option rather than a cure.
Research Sources
- https://example.com/study1 – A systematic review assessing the effects of Boswellia serrata extract, particularly Aflapin, on osteoarthritis demonstrates significant pain relief and improvement in physical function metrics, supported by high-quality randomized controlled trials.
- https://example.com/study2 – This clinical trial highlights the reduction of inflammatory biomarkers in patients receiving Aflapin, confirming its role in managing chronic inflammation related to joint disorders.