African Mango Seed Extract Irvingia Gabonensis Igob 131
Also known as: African Mango, Dikka, Ogbono, Irvingia gabonensis
Overview
Irvingia gabonensis, commonly referred to as African mango, is a tree native to Central and West Africa. The seeds of its fruit are uniquely high in fiber and publicly recognized for their weight loss and metabolic health benefits. Traditionally used in folk medicine, it is now a popular dietary supplement. Critical noted applications center around weight reduction and improvements in metabolic syndrome parameters. Current research, including numerous randomized controlled trials and systematic reviews, supports its efficacy, although evidence quality varies, with some studies indicating high risk of bias. Key characteristics include its potential to lower cholesterol levels through bile acid binding, fostering numerous metabolic pathways. The extract is often taken in the form of IGOB131, which is a proprietary version of the seed extract, to enhance bioavailability and efficacy.
Benefits
Research indicates several evidence-backed benefits of Irvingia gabonensis, particularly in promoting weight loss and improving metabolic health. A systematic review involving five randomized controlled trials concluded that supplementation leads to an average weight reduction of 8.71% and a 7.6% reduction in waist circumference. It has also been documented to enhance HDL cholesterol levels by approximately 10% and reduce triglycerides by about 12%. Notably, the extract shows a significant impact on individuals who are overweight or suffer from metabolic syndrome, displaying moderate to large effect sizes that are deemed clinically significant. Benefits are often observed within just 4 weeks and continue to manifest over longer durations.
How it works
The mechanism of action behind Irvingia gabonensis involves the modulation of lipid metabolism and adipogenesis. It downregulates PPARγ and leptin while upregulating adiponectin, consequentially influencing fat cell differentiation and metabolic profiles. By binding to bile acids, the extract can reduce cholesterol absorption, enhancing cardiovascular health. Its interactions extend to the endocrine system, notably improving levels of adiponectin and leptin, which regulate hunger and fat storage, thereby promoting overall metabolic efficiency.
Side effects
Irvingia gabonensis is generally considered safe for consumption, with no major adverse effects reported, although limitations exist due to variability in study quality. Common side effects have yet to be definitively established, as limited data suggest minimal adverse effects across studies. Rarely reported side effects (<1%) do not raise significant concerns; however, patients should exercise caution when combining this supplement with other medications, particularly those affecting blood glucose or lipid levels. Pregnant and breastfeeding women should consult healthcare providers before use due to a lack of research in these populations. Overall, although the safety profile is promising, ongoing scrutiny in long-term usage is advised.
Dosage
The typical effective dosage of Irvingia gabonensis ranges from 150 mg to 300 mg per day, with most studies supporting 150 mg taken in two doses before meals as a baseline effective measure. Timing is significant; administration 30-60 minutes prior to meals is recommended to maximize its desirable effects. While there is no formally established maximum safe dose, doses up to 300 mg have been consistently utilized without noticeable adverse effects. Although the proprietary extract IGOB131 is frequently examined in research, other formulations may be viable options. The presence of fiber potentially enhances the absorption and biological availability of the active compounds.
FAQs
How long does it take to see results?
Benefits can often be observed as early as 4 weeks after initiating supplementation.
Are there any interactions with medications?
Caution is recommended with medications that influence blood sugar or lipid levels.
Is it safe for everyone?
While generally safe, use under medical supervision is advised, especially for those with chronic conditions.
What is the best timing for administration?
It is suggested to take the extract 30-60 minutes before meals to enhance its effects.
What results can I expect?
Significant improvements in body weight, body fat, waist circumference, and various metabolic parameters are common.
Research Sources
- https://magistralbr.caldic.com/storage/product-files/69448140.pdf – This source discusses the efficacy and safety of Irvingia gabonensis in clinical contexts, highlighting its role in weight management and metabolic syndrome.
- https://www.mskcc.org/cancer-care/integrative-medicine/herbs/irvingia-gabonensis – The Memorial Sloan Kettering Cancer Center details the traditional uses and current research findings on Irvingia gabonensis, particularly its metabolic health applications.
- https://www.healthline.com/nutrition/african-mango – Healthline provides a comprehensive overview of African mango, focusing on its active components, health benefits, dosage, and potential side effects based on recent studies.
- https://pubmed.ncbi.nlm.nih.gov/19254366/ – A study on the health and weight loss effects of Irvingia gabonensis, revealing significant impacts on body composition and metabolic markers among participants.
- https://www.jscimedcentral.com/jounal-article-info/Annals-of-Public-Health-and-Research/Positive-Effect-of-Irvingia-Gabonensis-on-Health-and-Weight-Loss-11774 – This article covers positive health outcomes associated with Irvingia gabonensis, including its weight loss potential and generalized effects on metabolic health.