Akebia Trifoliata Stem Extract
Also known as: Three-leaf Akebia, Chocolate Vine, *Akebia trifoliata*
Overview
*Akebia trifoliata* is a plant species native to East Asia, recognized for its medicinal properties, particularly its stem, leaf, and fruit extracts. Traditionally utilized for its diuretic, hepatoregenerative, neuroprotective, analgesic, anti-inflammatory, and anti-obesity effects, the extract is gaining popularity in cosmetology as well. It is rich in triterpenoid saponins and phenolic compounds, which contribute to its antioxidant and potential anticancer properties. Despite a moderate level of research maturity concerning its phytochemical and pharmacological attributes, there is a noted deficiency in high-quality clinical trials that validate its efficacy.
Benefits
Research indicates potential benefits of *Akebia trifoliata*, including significant anti-gastric cancer activity and antioxidant effects predominantly from fruit peel extracts. Studies suggest that while antibacterial and anticancer properties may also be present, further research is required to substantiate these claims in human populations. Due to the limited scope of available clinical data, specific populations that could benefit most are not well-documented, and overall data on effect sizes and clinical significance remain scarce.
How it works
The health benefits of *Akebia trifoliata* are attributed primarily to its triterpenoid saponins and phenolic compounds, which are believed to modulate various cellular pathways, exerting anti-inflammatory and antioxidant effects. It potentially interacts with the digestive, nervous, and immune systems, although specific molecular interactions are not thoroughly defined, and data on absorption and bioavailability remains limited.
Side effects
Generally, *Akebia trifoliata* is considered safe when used traditionally; however, comprehensive safety profiles are lacking due to limited research. Common side effects are not well-documented, with no reports of uncommon or rare side effects. Potential drug interactions remain unstudied, and specific contraindications have not been identified. Caution is advised for pregnant or breastfeeding women due to insufficient safety data during these phases.
Dosage
Currently, no minimum effective dose has been established for *Akebia trifoliata*, nor are optimal or maximum dosage ranges defined. Timing considerations have not been specified, and different extraction methods may influence bioactivity. Factors affecting absorption have not been sufficiently studied, and required cofactors remain unidentified.
FAQs
Is *Akebia trifoliata* safe to use?
While generally considered safe, comprehensive safety data are lacking; consultation with healthcare professionals is recommended.
How long before I can expect to see results?
Expected results can vary widely depending on the specific preparation and individual response; there is currently insufficient research to define a timeline.
Can I use *Akebia trifoliata* as a substitute for prescribed medications?
No, it should not be considered a substitute; lack of clinical evidence means it cannot replace conventional treatments.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/34352331/ – This study focuses on the extraction process and investigates the anti-gastric cancer activity of *Akebia trifoliata* using in vitro cancer cells, noting the reflux extraction method's efficacy in inhibiting gastric cancer, although it lacks human clinical data.
- https://pubmed.ncbi.nlm.nih.gov/24311842/ – The study highlights the isolation and identification of antioxidant compounds from fruit peels of *Akebia trifoliata*, emphasizing their significant antioxidant activity, although it primarily centers on chemical rather than clinical outcomes.
- https://www.jstage.jst.go.jp/article/fstr/29/1/29_FSTR-D-22-00127/_html/-char/en – This review discusses the phytochemical composition and ethnopharmacological uses of *Akebia* species, suggesting potential applications in anti-inflammatory and anticancer therapies but lacking new clinical data.
