Albion Bororganic Glycine
Also known as: Boron, Bororganic Glycine, Albion® Bororganic Glycine
Overview
Boron is a trace mineral found naturally in a variety of foods such as fruits, vegetables, and nuts. In supplement form, it is often marketed as bororganic glycine, a form where boron is chelated to the amino acid glycine. Boron plays a crucial role in mineral metabolism, hormone regulation, and exhibits antioxidant and anti-inflammatory properties. Current research shows moderate evidence of its benefits, particularly in the management of lower urinary tract symptoms (LUTS), such as nocturia, and it may have an impact on bone health and inflammation. The evidence base is evolving, and while some studies support its efficacy, further high-quality and long-term research is necessary to solidify its claims.
Benefits
Boron supplementation has demonstrated specific benefits, particularly for men experiencing LUTS. A pilot clinical trial indicated a 64% reduction in nocturia among men who took 10 mg of boron as part of a formula for 60 days. Additionally, boron may reduce inflammation markers, which can help manage LUTS and other inflammatory conditions. Some potential secondary benefits include easing menstrual cramps and possibly influencing estrogen levels in post-menopausal women. The overall strength of evidence supports its use for managing nocturia, though further research is needed for broader claims and outcomes.
How it works
Boron influences hormone regulation, particularly estrogen, and affects the metabolism of essential minerals like calcium, magnesium, and phosphorus. Its anti-inflammatory effects are evidenced by the reduction of markers such as TNF-α and IL-6. Boron is thought to modulate signaling pathways that affect growth factors associated with prostate health, which could benefit those with LUTS.
Side effects
Boron is generally safe at doses up to 20 mg daily, with no common side effects noted at this level. Some individuals may experience irritability, tremors, headaches, diarrhea, or vomiting when taking higher doses. In rare cases, excessive consumption can lead to poisoning, causing severe gastrointestinal issues. Caution is advised for people with kidney disease, as boron can strain renal function. Additionally, individuals with hormone-sensitive health conditions, such as certain cancers, should avoid boron supplementation due to its estrogen-like effects. Pregnant and breastfeeding women are advised to limit intake to 20 mg daily to mitigate risks.
Dosage
The effective dosage for boron supplementation is typically 10 mg daily, especially for LUTS and nocturia, and the upper limit for routine supplementation is 20 mg per day. It is advisable to administer the supplement before bedtime for those specifically targeting nocturia. Bororganic glycine is noted for its improved bioavailability compared to other forms of boron, but general absorption factors remain under-researched. Patients should adhere to recommended doses to maintain safety and avoid adverse effects.
FAQs
Is boron safe to take?
Yes, boron is considered safe at doses up to 20 mg daily but can cause harm at higher doses.
When should I take boron supplements?
It is recommended to take boron supplements before bedtime if you're targeting nocturia.
How long does it take to see results from boron supplementation?
Benefits such as reduced nocturia can typically be expected within 60 days of supplementation.
Can boron help with athletic performance?
There is a lack of strong evidence to support that boron improves athletic performance or muscle mass.
Research Sources
- https://www.lifeextension.com/magazine/2019/7/reduce-nightime-urinary-frequency-in-men – A pilot clinical trial indicated that a formulation containing bororganic glycine significantly reduced nocturia in men with mild LUTS, noting a drop from 87% to 23% in experiences of nocturia after 60 days.
- https://www.webmd.com/vitamins/ai/ingredientmono-894/boron – This source provides an overview of boron's uses and effects, demonstrating its potential benefits and the varying evidence supporting different health claims.
- https://pubmed.ncbi.nlm.nih.gov/32521609/ – A systematic review evaluating boron's effectiveness for various uses, highlighting its role in addressing boron deficiency and potential impacts on certain conditions, with calls for more solid evidence.
- https://pubmed.ncbi.nlm.nih.gov/37851316/ – Research on the importance of mineral supplementation, including boron, outlining its synergy with hormone regulation and mineral metabolism.
- https://www.researchgate.net/publication/374807577_The_effect_of_glycine_administration_on_the_characteristics_of_physiological_systems_in_human_adults_A_systematic_review – This systematic review discusses the physiological impact of glycine, providing context for its chelation with minerals like boron and potential health benefits.
