Albion Copper Bisglycinate
Also known as: Copper glycinate, Copper bisglycinate chelate, Copper bisglycinate
Overview
Copper bisglycinate is a chelated form of copper, where copper is bound to two glycine molecules. As an essential trace mineral, copper is present in various foods such as shellfish, nuts, and legumes. This dietary supplement is primarily utilized for its potential benefits in promoting antioxidant function, immune health, and supporting bone metabolism. The chelation with glycine is believed to enhance the bioavailability of copper, potentially offering fewer gastrointestinal side effects compared to non-chelated forms. Research on copper bisglycinate is still emerging, featuring mostly narrative reviews and limited clinical trials, suggesting a need for more robust studies to ascertain its overall effects and applications.
Benefits
Copper bisglycinate may provide several evidence-based benefits. It is associated with enhanced antioxidant function, which supports the body's defense against oxidative stress. Some indications suggest that copper supplementation can benefit bone health, particularly bone mineral density, but specific and conclusive evidence for copper bisglycinate remains limited. Furthermore, copper plays a role in immune function and connective tissue health, although direct studies on bisglycinate form are sparse. Populations such as postmenopausal women may experience benefits from copper supplementation, but additional studies are required to quantify the significance of these effects. Overall, while preliminary findings are promising, more research is essential to articulate the clinical applicability of copper bisglycinate supplementation.
How it works
Copper bisglycinate exerts its effects through several biological mechanisms, primarily by functioning as a co-factor for enzymes such as superoxide dismutase and cytochrome c oxidase, which are crucial for antioxidant defense and cellular energy production. The chelation with glycine enhances the absorption of copper into the body, minimizing gastrointestinal discomfort that may arise with other copper forms. By interacting with the immune system, skeletal system, and cardiovascular system, copper plays a vital role in maintaining overall health. Enhanced bioavailability is believed to be a significant advantage of the bisglycinate form.
Side effects
Copper bisglycinate is generally safe when taken within the recommended dietary allowances; however, excessive intake can result in toxicity. The most commonly reported side effects (greater than 5%) include gastrointestinal issues such as nausea and diarrhea, though these are less frequent compared to other copper forms. Uncommon side effects (1-5%) may involve headaches, dizziness, and allergic reactions, with limited specific data on bisglycinate. Rare side effects (less than 1%) include severe reactions like liver damage or neurological symptoms, typically associated with high doses of copper. Caution is advised for individuals with conditions like Wilson's disease, which hinders copper metabolism, and those taking medications that may interact with copper supplements, such as zinc. Pregnant women and children should seek medical advice before supplementation.
Dosage
The minimum effective dose of copper bisglycinate is not clearly established, but general recommendations suggest an intake of approximately 900 μg/day for adults. Typical supplement forms usually contain 1-2 mg of copper daily. The Tolerable Upper Intake Level for adults is set at 10 mg/day. Although specific timing for supplementation is not mandated, absorption may improve when taken with food. Chelated forms like copper bisglycinate are recommended for better bioavailability and reduced side effects. Vitamin C may further enhance copper absorption. Users should stay within safe limits to avoid toxicity.
FAQs
Is copper bisglycinate safe?
Copper bisglycinate is generally considered safe at recommended doses, but high intake can cause toxicity.
When should I take copper bisglycinate?
There are no specific timing recommendations; it can be taken with or without food.
What benefits should I expect?
It may enhance antioxidant function and support bone health, but conclusive benefits need further research.
Are all copper supplements the same?
No, chelated forms like copper bisglycinate may have better bioavailability than other types.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/36728680/ – This study discusses the potential benefits of copper supplementation for bone health and its antioxidant functions but highlights the need for more extensive research specific to forms like copper bisglycinate.
- https://balchem.com/hnh/products/mn/trace-minerals/copper-bisglycinate-chelate/ – Manufacturer details on copper bisglycinate suggest enhanced absorption and antioxidant function, but independent verification of these claims is limited.
- https://www.mdpi.com/2072-6643/13/7/2246 – This literature review discusses various supplements and their effects, noting potential advantages of chelated minerals like copper bisglycinate in terms of reducing gastrointestinal discomfort.
- https://www.advancingnutrition.org/resources/anemia-toolkit/effects-oral-ferrous-bisglycinate-supplementation-hemoglobin-and-ferritin – A systematic review related to ferrous bisglycinate demonstrates the benefits of chelated minerals and provides a model for understanding potential implications for similar compounds like copper bisglycinate.
- https://go.drugbank.com/drugs/DB01373 – A resource highlighting pharmacological data on copper, including its interactions and implications for clinical use.
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