Albion Selenium Glycinate
Also known as: Selenium glycinate, Selenium chelate, Albion Selenium Glycinate, Selenium Glycinate
Overview
Selenium glycinate is a chelated form of the essential trace mineral selenium, bound to the amino acid glycine. This organic form is designed to enhance bioavailability compared to inorganic selenium compounds. Selenium is naturally found in foods like Brazil nuts, seafood, and meats, and plays a crucial role in antioxidant defense, immune function, and thyroid health. As a supplement, selenium glycinate is used to support these functions and protect cells from oxidative stress. While extensive research supports the benefits of selenium supplementation in general, specific data on Albion Selenium Glycinate (a branded form) is somewhat limited, with most studies focusing on selenium or other organic forms like selenomethionine. However, the chelated nature of selenium glycinate suggests improved absorption and tolerance. High-quality evidence supports selenium's biological effects, making it a valuable supplement for those with selenium deficiencies or those seeking antioxidant and immune support.
Benefits
Selenium glycinate supplementation primarily enhances immune function and reduces oxidative stress. A systematic review and meta-analysis demonstrated that selenium supplementation significantly improves immune markers (p < 0.05). Organic forms like selenium glycinate are expected to offer similar benefits due to their improved bioavailability. An RCT comparing different selenium forms showed reductions in oxidative stress markers with selenium supplementation. Secondary benefits include supporting thyroid hormone metabolism and potentially reducing inflammation. Some meta-analyses suggest potential benefits in cancer prevention and cardiovascular health, although the evidence is mixed. Benefits are more pronounced in selenium-deficient populations, and trauma patients may experience improved prognosis with selenium supplementation, though this evidence is preliminary. Improvements in immune function are typically moderate but consistent, while reductions in oxidative stress markers are statistically significant.
How it works
Selenium glycinate works primarily by acting as a cofactor for selenoproteins, such as glutathione peroxidases and thioredoxin reductases. These selenoproteins are critical for reducing oxidative damage by neutralizing free radicals. Selenium also plays a role in modulating immune cell function and inflammatory responses. It supports the body's antioxidant defense systems and influences thyroid hormone metabolism. The chelation of selenium with glycine enhances its absorption and bioavailability compared to inorganic forms, reducing gastrointestinal irritation. By participating in these biological pathways, selenium glycinate helps maintain cellular health and supports overall physiological function.
Side effects
Selenium supplementation with selenium glycinate is generally safe at recommended doses. Common side effects are rare, but mild gastrointestinal discomfort is possible. Uncommon side effects, occurring in 1-5% of users, may include mild nausea or a metallic taste. Rare side effects, occurring in less than 1% of users, include selenium toxicity (selenosis) at very high doses, characterized by hair loss, nail brittleness, and neurological symptoms. Selenium may interact with chemotherapy agents and anticoagulants, so caution is advised. It is contraindicated to take excessive doses in populations with adequate selenium status. Pregnant and lactating women should use selenium glycinate under medical supervision to ensure safety and appropriate dosage.
Dosage
The minimum effective dose of selenium is typically 55 mcg/day, which is the RDA for adults. Supplement doses commonly range from 100 to 200 mcg/day. The upper tolerable intake level is 400 mcg/day to avoid toxicity. Selenium glycinate can be taken with or without food, but consistent daily intake is recommended. Chelated forms like selenium glycinate may allow for lower doses due to better absorption. Absorption is enhanced by chelation but can be reduced by high doses of competing minerals. Adequate protein and vitamin E intake may support selenium function. It's important not to exceed the upper limit of 400mcg/day to prevent adverse effects.
FAQs
Is Albion Selenium Glycinate more effective than other forms?
While direct RCTs on Albion Selenium Glycinate are limited, chelated organic forms generally have better bioavailability than inorganic forms, potentially leading to improved effectiveness.
Is it safe to take daily?
Yes, selenium glycinate is safe to take daily within recommended doses (up to 400 mcg/day) for most individuals. Exceeding this limit may lead to adverse effects.
How long until benefits appear?
Noticeable changes in selenium status and improvements in oxidative stress markers may take several months of consistent supplementation. Individual results can vary.
Can it prevent diseases?
Selenium supports immune and antioxidant function, which are important for overall health, but it is not a cure or guaranteed preventive agent for any specific disease.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/36789948/ – This systematic review and meta-analysis of RCTs examined the impact of selenium on immune function. The findings indicated that selenium supplementation significantly improved immune markers (p < 0.05), suggesting a beneficial role in enhancing immune response. However, the study acknowledged heterogeneity in selenium forms and doses as a limitation.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4125492/ – This randomized controlled trial compared the effects of different selenium forms on oxidative stress. The study found that selenium supplementation reduced oxidative stress biomarkers, with organic forms showing better effects than inorganic forms. The results suggest that organic selenium compounds may be more effective in mitigating oxidative damage.
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1263853/full – This umbrella review analyzed 76 meta-analyses to assess the relationship between selenium intake and various health outcomes. The review found that selenium intake was linked to multiple health outcomes, but the quality of evidence varied from low to moderate. The authors noted limitations such as publication bias and heterogeneity in doses and populations.
- https://bluebonnetnutrition.com/products/albion-yeast-free-selenium-glycinate-vegetable-capsules – This is a product page for Albion Yeast-Free Selenium Glycinate Vegetable Capsules by Bluebonnet Nutrition. It highlights that the product uses Albion's patented selenium glycinate, which is designed for enhanced absorption and bioavailability. The product is marketed as a dietary supplement to support antioxidant defense and overall health.
- https://www.mdpi.com/2072-6643/14/2/342 – This study investigates the role of selenium in human health, focusing on its antioxidant and anti-inflammatory properties. It discusses the importance of selenium in selenoproteins, which are involved in various biological processes, including immune function and thyroid hormone metabolism. The study highlights the potential benefits of selenium supplementation in preventing chronic diseases.
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