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Albizia Bark Extract

Also known as: Albizia julibrissin Durazz., Albizia lebbeck (L.) Benth., Silk Tree, Mimosa Tree, Albizia julibrissin

Overview

*Albizia* bark extracts are derived from trees belonging to the *Albizia* genus, notably *Albizia julibrissin* and *Albizia lebbeck*. These extracts are utilized in traditional medicine for their anti-inflammatory and neuroprotective properties. The bark contains bioactive compounds such as triterpenoid saponins, contributing to its medicinal effects. Although it has a long history of use, research maturity is still in the emerging phase, with most studies being in vitro or based on animal models, lacking sufficient human clinical trials to establish definitive health benefits. Key characteristics include potential applications in chronic inflammatory conditions and wound healing. The quality of available evidence remains limited, necessitating further investigation into its safety and effectiveness in human populations.

Benefits

The primary evidence-based benefit of *Albizia julibrissin* bark extract includes its demonstrated anti-inflammatory effects observed in vitro, with implications for chronic inflammatory diseases. Secondary findings suggest neuroprotective qualities, particularly noted in extracts from *Albizia lebbeck*, indicating potential against neurotoxicity. However, due to the scarcity of human trials, the extent of these benefits, effect sizes, and clinical significance remain poorly established. Consequently, specific populations that may benefit have not been substantiated, and empirical support for time-expected benefits is not available.

How it works

The mechanism of action for *Albizia julibrissin* involves the inhibition of nitric oxide production and modulation of inflammatory pathways, which may subsequently interact with immune and nervous systems. Although its absorption and bioavailability have not been thoroughly investigated, its biological activities suggest a potential beneficial impact on inflammatory responses and neuroprotection.

Side effects

Currently, there is a limited understanding of the safety profile of *Albizia julibrissin*, particularly in human populations due to the absence of extensive clinical trials. While certain studies imply potential cytotoxic effects at high concentrations, comprehensive data on common, uncommon, or rare side effects are yet to be established. Furthermore, the interactions with other drugs and any contraindications remain largely unstudied, and no specific guidance has been delineated for special populations. Caution is advised until more human-related safety data is available.

Dosage

There are no established guidelines for the effective or safe dosing of *Albizia julibrissin* bark extract for humans as current studies do not provide sufficient evidence for specific dosing recommendations. Optimal dosage ranges, maximum safe doses, and specific timing considerations have not been determined. Moreover, the form of the extract and varying absorption factors are not well-studied, which further complicates dosing recommendations.

FAQs

Can *Albizia julibrissin* be used for inflammation?

In vitro studies suggest potential anti-inflammatory effects, but human efficacy has not been established.

Is *Albizia* extract safe to use?

Limited human safety data exists, with potential cytotoxic effects at high concentrations; caution is advised.

What are the common side effects?

Common and uncommon side effects remain unknown due to the lack of human trials.

How should I take *Albizia julibrissin*?

Dosing guidelines are not available; further research is essential before establishing recommended use.

Are there established benefits for specific populations?

Currently, no specific population benefits have been well-documented due to limited research.

Research Sources

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-3400143 – This study presents in vitro evidence of anti-inflammatory effects from *Albizia julibrissin* bark extract through inhibition of nitric oxide production. However, it emphasizes the limitation of lacking human clinical data.
https://www.mdpi.com/1424-8247/16/7/989 – The article discusses neuroprotective effects found in *Albizia lebbeck* leaf extracts against glutamate-induced toxicity, highlighting a potential area of benefit, but notes the study's focus on leaf rather than bark extract.