Alisma Orientale Rhizome Extract
Also known as: Alisma, Water Plantain, Ze Xie, Taeg-Sa, Alisma orientale
Overview
*Alisma orientale* rhizome is a herbal extract harvested from the rhizomes of the *Alisma orientale* plant, primarily found in East Asia. Traditionally used in Chinese and Korean medicine, it is recognized for its diuretic, anti-inflammatory, and cholesterol-lowering properties. The rhizome contains active compounds such as triterpenoids and sesquiterpenoids, notably alisols, contributing to its therapeutic effects. Research surrounding *Alisma orientale* is in moderate maturity, with various studies ongoing to delineate its pharmacological mechanisms. Initial findings demonstrate its efficacy in treating conditions such as edema and hyperlipidemia, although the evidence quality varies. This herbal remedy is generally consumed as a decoction or extract, further emphasizing the cultural contexts of its application in traditional medicine.
Benefits
The primary benefits of *Alisma orientale* include significant diuretic effects and potential roles in managing hyperlipidemia and edema. In specific populations, such as those with hypertension or pregnancy-induced hypertension, *Alisma orientale* may offer additional therapeutic advantages. Secondary benefits observed in studies highlight its anti-inflammatory, hepatoprotective, and immunomodulatory activities. However, quantitative data on these effects are limited. One study indicates that *Alisma orientale* could aid in regulating lipid metabolism, contributing to cardiovascular health. While these benefits are supported by various animal studies, clinical research in human subjects remains insufficient, calling for rigorous trials to confirm these findings.
How it works
*Alisma orientale* modulates biological pathways related to water metabolism, lipid management, and renal function. Its active compounds, particularly alisol B 23-acetate, have been noted to interact with drug-metabolizing enzymes, influencing hepatic functions. The extract's diuretic action is primarily mediated through its effects on the renal system, promoting fluid excretion, while its hepatoprotective effects suggest a protective role in liver health. However, comprehensive studies on absorption and bioavailability are lacking, necessitating further exploration.
Side effects
While *Alisma orientale* is generally considered safe when used appropriately, the potential side effects include gastrointestinal upset, which is relatively common but not extensively documented. Rarely, high doses or prolonged use may lead to hepatotoxicity or nephrotoxicity. Individuals with existing kidney or liver diseases should exercise caution when using this supplement. Furthermore, interactions with diuretics or antihypertensive medications may occur, warranting a careful evaluation of concurrent treatments. Due to insufficient safety data, *Alisma orientale* is contraindicated for use during pregnancy and breastfeeding. It is imperative to consult a healthcare provider prior to initiating its use, particularly for those with pre-existing health conditions.
Dosage
Currently, there are no established standardized dosages for *Alisma orientale*. Traditional use indicates various forms, commonly as decoctions or extracts, with maximum safe doses noted at 2,000 mg/kg/day in animal studies without adverse effects. However, specific dosing effectiveness is not clearly defined, and optimal dosing will vary based on individual health needs and conditions. Tracking of proper timing in administration remains unspecified; thus, it is strongly advised to adhere to traditional usage guidelines or seek professional guidance. Further research is needed to clarify the pharmacodynamics and establish comprehensive dosing protocols for human applications.
FAQs
Is *Alisma orientale* safe to use?
Generally considered safe, but interactions with certain medications exist. Consult a healthcare provider before use.
How should *Alisma orientale* be taken?
Commonly used as a decoction or extract. Follow traditional guidelines or consult a healthcare provider for tailored advice.
What are the expected benefits of *Alisma orientale*?
It may help with edema and hypertension, although results can vary; evidence from clinical studies remains limited.
Can I use *Alisma orientale* if I am pregnant?
Pregnancy and breastfeeding are contraindications due to a lack of safety data. Consultation with a healthcare professional is crucial.
Does *Alisma orientale* have any side effects?
Potential side effects include gastrointestinal upset and rare cases of hepatotoxicity at high doses. Use with caution.
Research Sources
- https://d-nb.info/1240577338/34 – This animal study assessed toxicity over 90 days, finding no adverse effects up to 2,000 mg/kg/day, indicating good safety margins for *Alisma orientale*.
- https://pubmed.ncbi.nlm.nih.gov/18254241/ – This in vivo study explores the impact of *Alisma orientale* extract and alisol B 23-acetate on hepatic drug-metabolizing enzymes, providing insights into potential metabolic interactions.
- https://pubmed.ncbi.nlm.nih.gov/28662316/ – Utilizing computational models, this study investigates therapeutic potential for pregnancy-induced hypertension, cautioning about potential hepatonephrotoxicity associated with *Alisma orientale*.
- https://osf.io/mepkc/?action=download – A theoretical model investigating the mechanisms of action for *Alisma orientale* concerning pregnancy-induced hypertension; requires empirical validation.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1027112/full – This review discusses various pharmacological properties of *Alisma orientale*, underlining its traditional uses and potential benefits while highlighting the need for further clinical studies.
