Get Your Personalized Supplement StackSupplement Stack Quiz

Ancient Probiotics Blend

Also known as: Probiotics, Good bacteria, Beneficial microorganisms

Overview

Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. They are commonly found in fermented foods like yogurt, kefir, and sauerkraut, and are also available as dietary supplements. Probiotics are primarily used to support gut health and immune function, and emerging research suggests potential benefits in managing conditions such as irritable bowel syndrome (IBS) and non-alcoholic fatty liver disease (NAFLD). To be effective, probiotics must be alive, viable, and present in sufficient numbers to exert their beneficial effects. Research on probiotics is extensive, with numerous systematic reviews and meta-analyses exploring their impact on various health outcomes. However, the quality of evidence varies, with some conditions showing strong support and others requiring further investigation. Different strains of probiotics can have different effects, so it's important to choose a product that is appropriate for the specific health concern.

Benefits

Probiotics have demonstrated efficacy in improving symptoms of irritable bowel syndrome (IBS), with several studies showing a reduction in abdominal pain, bloating, and altered bowel habits. Emerging research indicates that probiotics may also reduce liver enzyme levels in patients with non-alcoholic fatty liver disease (NAFLD), suggesting a potential benefit for liver health. Additionally, some studies suggest that probiotics may influence muscle mass and strength in older adults, although more research is needed to confirm these findings. Children with food allergies may experience reduced eczema symptoms with probiotic supplementation. The effect sizes of these benefits vary depending on the specific condition and probiotic strain used, and benefits are typically observed within weeks to months of consistent use.

How it works

Probiotics exert their beneficial effects primarily by interacting with the gut microbiome. This interaction influences immune responses, reduces inflammation, and affects nutrient absorption. Probiotics can modulate cytokine production, influencing the balance of pro-inflammatory and anti-inflammatory signals in the body. They also play a role in maintaining the integrity of the gut epithelium by influencing tight junctions, which are crucial for preventing the leakage of harmful substances from the gut into the bloodstream. The effects of probiotics are not limited to the gastrointestinal tract; they can also have systemic effects through the gut-brain axis, influencing neurological and psychological processes.

Side effects

Probiotics are generally considered safe for most individuals. The most common side effects are mild gastrointestinal symptoms such as bloating, gas, or changes in bowel habits. These symptoms are usually transient and resolve on their own. Uncommon side effects are not consistently reported in clinical trials. Rare side effects, such as an increased risk of infection, may occur in severely immunocompromised individuals. Caution is advised when using probiotics in conjunction with immunosuppressive drugs, as the interaction is not well-documented. Probiotics are generally contraindicated in individuals with severe immunocompromised states or those with compromised gut integrity, such as critically ill patients. It is always recommended to consult with a healthcare provider before starting any new supplement, especially if you have underlying health conditions.

Dosage

The minimum effective dose of probiotics is typically in the range of 1 to 10 billion CFU (colony-forming units) per day. Optimal dosage ranges vary depending on the specific condition being addressed, often ranging from 1 to 50 billion CFU. Doses above 100 billion CFU are rarely used and may not provide additional benefits. Probiotics are best taken with food to enhance their survival through the stomach acid. Common forms include capsules and powders. The survival of probiotics through stomach acid is a crucial factor for their effectiveness. There are no specifically required cofactors for probiotic supplementation.

FAQs

How should probiotics be stored to maintain their viability?

Probiotics should be stored according to the manufacturer's instructions, typically in a cool, dry place or refrigerated, to maintain the viability of the live microorganisms.

Are probiotics safe for everyone?

Probiotics are generally safe, but individuals who are immunocompromised should consult a healthcare provider before use due to a potential risk of infection.

When is the best time to take probiotics?

Probiotics are best taken with meals to enhance their survival through the stomach acid and improve their chances of reaching the intestines.

How long does it take to see results from taking probiotics?

The time it takes to see results varies by condition; some individuals may notice benefits within weeks, while others may require several months of consistent use.

Are all probiotics the same?

No, not all probiotics are created equal. Different strains have different effects, so it's important to choose a product that is appropriate for the specific health concern.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC6927028/ – This systematic review and meta-analysis examined the effects of probiotics on patients with non-alcoholic fatty liver disease (NAFLD). The study found that probiotics were superior to placebo in improving liver enzyme levels, suggesting potential benefits for liver health in NAFLD patients. However, the authors noted heterogeneity among the included studies as a limitation.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10873954/ – This systematic review and meta-analysis explored the correlation between gut microbiome changes and sarcopenia in older adults. The findings suggest that probiotics may influence muscle mass and strength, indicating potential benefits in muscle health for older adults. The authors noted that the evidence is still emerging and further research is needed.
https://onlinelibrary.wiley.com/doi/10.1111/pai.70028?af=R – This systematic review and meta-analysis investigated the effects of probiotics on eczema symptoms in children with food allergies. The results indicated that probiotics may reduce eczema symptom scores in this population. The authors acknowledged that the number of studies was limited, suggesting a need for more research in this area.
https://academic.oup.com/nutritionreviews/advance-article/doi/10.1093/nutrit/nuae145/7822505 – This review provides an overview of the current research on probiotics and their impact on various health conditions. It highlights the potential benefits of probiotics in improving gut health, immune function, and managing certain diseases. The review emphasizes the importance of strain-specific effects and the need for personalized probiotic interventions.
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0278356 – This study investigated the effects of probiotic supplementation on the gut microbiome composition and diversity in healthy adults. The results showed that probiotic supplementation can alter the gut microbiome, leading to changes in bacterial abundance and diversity. The authors suggest that these changes may contribute to the health benefits associated with probiotic consumption.