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Andrographis Paniculata Leaf Extract

Also known as: Andrographis paniculata, King of Bitters, Chuan Xin Lian

Overview

Andrographis paniculata, commonly known as King of Bitters, is a plant native to Asia and India, widely recognized for its intensely bitter taste and extensive use in traditional medicine, particularly in Ayurvedic and traditional Chinese medicine. The plant is characterized by its bioactive compounds, primarily andrographolides, which are believed to possess significant anti-inflammatory and antioxidant properties. It is available in various forms, including capsules, tablets, and extracts. Traditionally, Andrographis paniculata has been employed to treat a range of ailments, including fever, respiratory infections, and digestive issues. Current research suggests its efficacy in alleviating symptoms of acute respiratory tract infections (ARTIs). While research is ongoing, the quality of evidence varies, with some high-quality systematic reviews and meta-analyses supporting its benefits.

Benefits

Andrographis paniculata is primarily recognized for its effectiveness in relieving symptoms of acute respiratory tract infections (ARTIs). Studies indicate a reduction in the time to symptom resolution, suggesting a beneficial effect on the duration of respiratory illnesses. Additionally, research suggests potential antiplasmodial effects, indicating a possible role in malaria treatment, along with improvements in hematological indices. These benefits are generally observed in adults with ARTIs, although further research is necessary to determine its efficacy in other populations. The effect sizes for symptom relief in ARTIs are moderate, but specific effect sizes can vary depending on the study. Benefits are typically noticeable within a few days of initiating treatment.

How it works

Andrographis paniculata exerts its effects through several biological pathways, primarily involving its anti-inflammatory, antioxidant, and potentially immunomodulatory properties, largely attributed to its bioactive compounds like andrographolides. It interacts with the body's immune and inflammatory pathways, modulating inflammatory mediators. While the precise molecular targets are not fully elucidated, the plant's compounds are believed to influence key processes involved in the inflammatory response. Oral administration is common, though limited data exists regarding its bioavailability. Further research is needed to fully understand the absorption and distribution mechanisms of its active components.

Side effects

Andrographis paniculata is generally considered safe for consumption, although some adverse effects have been reported. Common, non-serious side effects include gastrointestinal issues such as nausea and diarrhea, as well as skin reactions like rashes or itching. Serious adverse events are rare, with a pooled incidence of approximately 0.02 per 1000 patients. Due to its potential effects on blood sugar and clotting, Andrographis paniculata may interact with blood thinners and diabetes medications. It is contraindicated in pregnancy and breastfeeding due to a lack of safety data. Caution is advised for individuals with bleeding disorders or diabetes. Monitoring for gastrointestinal distress and skin reactions is recommended during use.

Dosage

The minimum effective dose of Andrographis paniculata typically starts at 300-400 mg per day of a standardized extract. Optimal dosage ranges generally fall between 300-1200 mg per day, depending on the specific condition being treated. While a maximum safe dose is not definitively established, doses exceeding 1200 mg per day are less commonly studied. It is recommended to take Andrographis paniculata with meals to mitigate potential gastrointestinal side effects. Common forms include capsules and tablets. The bioavailability of Andrographis paniculata may be enhanced when taken with fatty meals. No specific cofactors are required for its efficacy.

FAQs

How should I start taking Andrographis paniculata?

Begin with a lower dose (e.g., 300-400mg) and monitor for any side effects, such as gastrointestinal issues or skin reactions. Consult with a healthcare provider for personalized advice.

Is Andrographis paniculata safe?

Generally safe, but monitor for gastrointestinal issues. It may interact with blood thinners and diabetes medications. Avoid during pregnancy and breastfeeding. Consult a healthcare provider if you have underlying health conditions.

When is the best time to take Andrographis paniculata?

Take with meals to reduce the likelihood of gastrointestinal side effects. Consistent timing can help maintain stable levels in your system. Follow specific recommendations from your healthcare provider.

What results can I expect from taking Andrographis paniculata?

You may experience symptom relief from acute respiratory tract infections within a few days. It is not a cure but can aid in managing symptoms. Individual results may vary.

Is Andrographis paniculata a cure for infections?

No, it is not a cure for infections. It may help relieve symptoms, particularly in acute respiratory tract infections, but it should not replace conventional medical treatments. Consult a healthcare professional for proper diagnosis and treatment.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/33372366/ – A systematic review and meta-analysis assessed the safety of Andrographis paniculata by analyzing adverse event incidence in patients with upper respiratory tract infections, noninfective diarrhea, and autoimmune diseases. The study found that while serious adverse events were rare, non-serious adverse events, particularly gastrointestinal and skin disorders, were common.
https://eprints.soton.ac.uk/447277/ – A systematic review including 33 clinical trials found Andrographis paniculata to be beneficial and safe for relieving acute respiratory tract infection symptoms, though the methodological quality of the included studies was limited. This review supports the use of Andrographis paniculata for symptom management in ARTIs but highlights the need for higher-quality research.
https://pubmed.ncbi.nlm.nih.gov/38092319/ – An animal study evaluated the effects of Andrographis paniculata supplementation on antiplasmodial activity and male reproductive indices in mice infected with Plasmodium berghei. The study showed potential benefits in malaria treatment and improvements in hematological indices, suggesting a possible role in managing malaria-related complications.
https://onlinelibrary.wiley.com/doi/abs/10.1002/pds.5190 – This systematic review and meta-analysis provides evidence supporting the use of Andrographis paniculata for symptomatic relief of acute respiratory tract infections. The analysis highlights the need for further research with rigorous methodologies to confirm these findings and explore the full potential of Andrographis paniculata.