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Androsterone

Also known as: Androsterone, 3α-Androsterone, 3α-Hydroxy-5α-androstan-17-one

Overview

Androsterone is a naturally occurring steroid hormone produced in the body as a metabolite of testosterone and dihydrotestosterone (DHT). It is also found in some plants. While historically used in research related to androgenic activity, it is not commonly used as a dietary supplement due to limited human studies. Androsterone has been studied for its potential effects on mood and libido, but the evidence supporting these effects is limited. Research on androsterone is primarily animal-based or in vitro, with a scarcity of well-designed human trials. Therefore, the quality of available evidence is generally low. It interacts with androgen receptors and may influence the endocrine system, particularly affecting testosterone and DHT pathways. Due to the lack of comprehensive research, its efficacy and safety in humans remain uncertain.

Benefits

There is limited evidence to support specific benefits of androsterone supplementation in humans. Most studies are either animal-based or theoretical. Some studies suggest potential effects on mood and sexual function, but these are not well-substantiated in humans. No specific population benefits have been clearly established. Due to the lack of human studies, effect sizes and clinical significance are not well-defined. The time course of any potential benefits is also not established. More research is needed to determine if androsterone offers any tangible benefits.

How it works

Androsterone acts primarily through androgen receptors, potentially influencing mood and sexual function. It interacts with the endocrine system, particularly affecting testosterone and DHT pathways. The known molecular target is the androgen receptor. However, the absorption and bioavailability of androsterone are not well-studied in humans. Its mechanism of action is similar to other androgenic steroids, but the specific details and effects are not fully understood due to limited research.

Side effects

Due to limited data on human safety, the overall safety assessment of androsterone is uncertain. Potential risks are similar to those associated with other androgenic steroids. Common side effects are not well-documented, but may include acne, hair loss, or mood changes, similar to other androgens. Rare side effects may include more severe hormonal imbalances. Androsterone may interact with other hormones or medications affecting the endocrine system. It is contraindicated in pregnancy, breastfeeding, and conditions sensitive to hormonal changes. Caution is advised in individuals with hormonal imbalances or sensitivities. More research is needed to fully understand the side effect profile.

Dosage

Due to the lack of human studies, a minimum effective dose, optimal dosage ranges, and maximum safe dose have not been established for androsterone. Timing considerations are not applicable due to insufficient data. Form-specific recommendations are not available, and absorption factors are not well-studied. Required cofactors are also not established. Given the limited research and potential risks, it is crucial to consult with a healthcare professional before considering androsterone supplementation.

FAQs

Is androsterone recommended for general use?

Due to limited evidence, androsterone is not recommended for general use. Potential risks include hormonal imbalances and side effects similar to other androgens.

What are the potential safety concerns?

Potential risks include hormonal imbalances and side effects similar to other androgens. It may interact with other hormones or medications affecting the endocrine system.

What results can I expect from taking androsterone?

Expected results are not well-defined due to the lack of human studies. Most research is either animal-based or theoretical, so effects are not well-substantiated.

What is androsterone often confused with?

Androsterone is often confused with other androgenic compounds. Its effects are not well-studied in humans, so it's important to distinguish it from similar substances.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/35841524/ – This study investigates the impact of androgenic-anabolic steroids (AAS) on male fertility. It highlights that AAS use can lead to a reduction in sperm count and testicular volume, emphasizing the potential adverse effects on reproductive health. The research underscores the importance of understanding the hormonal consequences associated with AAS.
https://libguides.usc.edu/healthsciences/systematicreviews/databases – This resource provides a guide to databases for conducting systematic reviews in health sciences. It lists key databases such as PubMed, Cochrane Library, and Embase, which are essential for identifying relevant studies. The guide helps researchers efficiently search and gather evidence for comprehensive reviews.
https://bjsm.bmj.com/content/52/6/376 – This article discusses the challenges in interpreting and applying research findings in sports and exercise medicine. It emphasizes the importance of considering factors such as study design, sample size, and statistical significance. The article aims to improve the understanding and utilization of research evidence in clinical practice.
https://pubmed.ncbi.nlm.nih.gov/33045358/ – This study examines the effects of dehydroepiandrosterone (DHEA) on various health outcomes. It suggests that DHEA supplementation may have potential benefits for bone health and cognitive function, particularly in older adults. The research highlights the need for further investigation to confirm these findings and determine optimal dosages.
https://ijcscardiol.org/article/effects-of-low-to-moderate-doses-of-anabolic-steroids-on-lipid-profile-and-muscle-hypertrophy-in-resistance-training-practitioners-a-systematic-review-with-meta-analysis/ – This systematic review and meta-analysis investigates the effects of low to moderate doses of anabolic steroids on lipid profiles and muscle hypertrophy in resistance training practitioners. The study indicates that anabolic steroid use can lead to adverse changes in lipid profiles and significant increases in muscle mass. The findings underscore the potential cardiovascular risks associated with anabolic steroid use.