ANGELICA ARCHANGELICA FLOWER EXTRACT
Also known as: Angelica archangelica, Garden Angelica, Wild Celery, Norwegian Angelica
Overview
Angelica archangelica is a biennial plant belonging to the Apiaceae family, native to Europe and Asia. Traditionally, its roots, leaves, and seeds have been utilized for their rich content of bioactive compounds, including coumarins and flavonoids. It has been historically employed for addressing digestive issues, as a flavoring agent, and in folk medicine for various ailments. Modern applications focus on its antioxidant and anti-inflammatory properties, with emerging research suggesting potential neuroprotective effects. The plant is known for its distinctive aroma and tall stature, often found in damp environments. While research shows promise, more rigorous trials are needed to validate specific health benefits and establish optimal usage guidelines. Extracts are available in various forms, including capsules and teas.
Benefits
Angelica archangelica extract has demonstrated potential benefits in specific areas. Animal studies suggest it may alleviate pain in fibromyalgia models by increasing paw withdrawal thresholds. Human trials indicate possible cognitive function improvements in individuals with mild cognitive impairment, showing improved MMSE scores. These benefits are attributed to its antioxidant and anti-inflammatory properties. However, the effect sizes and clinical significance require further investigation. The time course of these benefits is not well-documented, necessitating additional research to understand the duration and consistency of effects. More high-quality studies are needed to confirm these findings and establish clear clinical recommendations.
How it works
Angelica archangelica's mechanism of action primarily involves its antioxidant activity, which helps neutralize free radicals and reduce oxidative stress. It also exhibits potential neuroprotective effects, possibly through acetylcholinesterase inhibition, which can enhance cognitive function. The extract interacts with the nervous and digestive systems, influencing neurotransmitter activity and gut health. However, the precise molecular targets and biological pathways are not fully elucidated, and further research is needed to understand the absorption, bioavailability, and specific interactions with body systems.
Side effects
Angelica archangelica is generally considered safe when used appropriately, but several potential side effects and precautions should be considered. Common side effects are not well-documented but may include gastrointestinal upset. Uncommon side effects may involve allergic reactions. Rare side effects include phototoxicity, particularly with prolonged sun exposure. Drug interactions may occur with blood thinners and diabetes medications. It is contraindicated in pregnancy and breastfeeding due to a lack of safety data. Caution is advised in individuals with bleeding disorders or diabetes. Due to the risk of phototoxicity, users should avoid prolonged sun exposure or use sun protection. Consult a healthcare provider before use, especially if you have underlying health conditions or are taking medications.
Dosage
The minimum effective dose of Angelica archangelica is not well-established and varies depending on the application. Animal studies have used extract dosages ranging from 100 to 400 mg/kg. The maximum safe dose is not well-defined, so caution is advised. Timing considerations are not specified and may depend on individual health goals. It is often used as a capsule or tea. Bioavailability is not well-studied, and required cofactors are not established. Due to limited research, it is essential to start with a low dose and monitor for any adverse effects. Consult a healthcare provider for personalized dosage recommendations.
FAQs
How do I ensure I'm using the correct plant?
Proper identification is crucial to avoid confusion with toxic species. Consult with an expert or use a reliable botanical guide to confirm the plant's identity before use.
What precautions should I take regarding sun exposure?
Avoid prolonged sun exposure due to the potential for phototoxicity. Use sun protection, such as sunscreen and protective clothing, when using Angelica archangelica.
Can Angelica archangelica replace medical treatment?
No, it is not a substitute for medical treatment. Consult a healthcare provider before use, especially if you have underlying health conditions or are taking medications.
What results can I expect from using this supplement?
Expected results are variable and may include improved cognitive function or pain relief. Individual responses can differ, and more research is needed to confirm these effects.
Are there any specific groups that should avoid this supplement?
Pregnant and breastfeeding women should avoid Angelica archangelica due to a lack of safety data. Individuals with bleeding disorders or diabetes should use it with caution.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/33047814/ – This study optimized extraction conditions for Angelica archangelica roots and evaluated its pain-reducing effects in a mouse model of fibromyalgia. The optimized extract, administered orally at doses of 100, 200, and 400 mg/kg, demonstrated a reduction in pain, suggesting potential benefits for fibromyalgia management. The research highlights the importance of extraction methods in maximizing the therapeutic potential of A. archangelica.
- https://journals.sagepub.com/doi/10.3233/ADR-200211?int.sj-abstract.similar-articles.1 – This double-blind, placebo-controlled trial investigated the effects of ferulic acid and Angelica archangelica extract on mild cognitive impairment. The results indicated significant improvements in cognitive function, as measured by MMSE and ADAS-Jcog scores, suggesting a potential therapeutic role for these compounds in managing cognitive decline. The study supports the use of A. archangelica as a cognitive enhancer.
- https://onlinelibrary.wiley.com/doi/10.1111/j.1447-0594.2010.00687.x – This study focused on the antioxidant properties of Angelica archangelica and Ginkgo biloba extracts, highlighting their potential health benefits. While specific outcomes related to Angelica archangelica flower extract were not detailed, the research underscores the importance of these extracts as antioxidants. The findings suggest a protective role against oxidative stress, contributing to overall health.
- https://www.mdpi.com/2076-3417/11/11/4804 – This study assessed the protective role of *A. archangelica* and *Ginkgo biloba* extracts as antioxidants, highlighting their potential health benefits. However, specific outcomes related to *A. archangelica* flower extract were not detailed.
- https://www.xiahepublishing.com/2835-6357/FIM-2023-00002 – This study optimized extraction conditions for *A. archangelica* roots and found that the extract reduced pain in a mouse model of fibromyalgia. The optimized extract was administered orally at doses of 100, 200, and 400 mg/kg.
