Angelica Gigas Extract
Also known as: Korean Angelica, Danggui, Angelica gigas Nakai
Overview
Angelica gigas Nakai, commonly known as Korean Angelica or Danggui, is a traditional herbal supplement native to Korea, primarily utilizing its root for various medicinal properties. It contains bioactive compounds such as decursin and decursinol, which are believed to provide numerous health benefits including support for memory health, pain management, and in some cases, treating conditions like cerebral ischemia and metabolic disorders. Recent studies have started to explore its pharmacokinetics and potential bioactivities. While evidence from in vitro and animal studies appears promising, more extensive human trials are necessary to validate its efficacy and safety comprehensively. Overall, this extract is gaining attention for its role in traditional medicine and potential modern applications.
Benefits
Research indicates that Angelica gigas Nakai may offer various health benefits. A pivotal clinical trial demonstrated a significant reduction in blood triglycerides, showcasing a decrease of 14.8 ± 16.1 mg/dL after 12 weeks of supplementation (p = 0.010). Furthermore, the extract exhibits inhibitory actions against key enzymes such as MAO-A, MAO-B, and cholinesterases, which highlights its potential in neuroprotection and management of neurodegenerative diseases. Animal studies suggest anticancer, analgesic properties, and possible pro-memory effects. While these benefits are compelling, they need to be corroborated with larger human trials to establish clinical significance. Specific populations, such as those with metabolic disorders or anxiety, may find particular benefit from this extract.
How it works
The mechanism of action of Angelica gigas Nakai involves the inhibition of several enzymes that regulate neurotransmitters, notably MAO-A, MAO-B, and β-secretase, which play a role in neurodegenerative processes. Additionally, it exhibits antioxidant and anti-inflammatory properties that could contribute to its neuroprotective effects and overall health benefits. The phytochemicals present, particularly decursin and its derivatives, also appear to engage with pathways involved in oxidative stress and inflammation, potentially enhancing cardiovascular function and mitigating metabolic risks.
Side effects
Angelica gigas Nakai appears to be generally safe when used at recommended doses, with clinical trials reporting no significant adverse effects. However, the data on side effects remain sparse, especially regarding long-term safety. Common side effects were not documented in existing studies, which may suggest a favorable safety profile. Special considerations should be noted for people with plant allergies, particularly to the Angelica genus, and caution is advised for pregnant or breastfeeding women due to lack of specific safety data. Drug interactions, particularly with medications metabolized by similar pathways as the extract, should be considered, though specific interactions are not well defined in the literature. Overall, prolonged use should be approached with caution as further research is needed.
Dosage
While the specific minimum effective dose of Angelica gigas Nakai is not clearly established, studies have typically utilized formulations containing 20% extract. The optimal dosage ranges remain undefined, although clinical trials utilizing this percentage have shown promising results with respect to blood triglyceride management. There is no formal guidance on the timing of ingestion, but adherence to dosing schedules used in clinical research is advisable. The extract can be obtained in various forms, such as capsules or hot-melt extruded formulations, which can influence its bioavailability. Safety thresholds and maximum dose limits remain to be confirmed through clinical investigation.
FAQs
Is Angelica gigas Nakai safe for long-term use?
Current studies indicate it is generally safe at studied doses, but long-term safety has not been thoroughly examined.
How should I take Angelica gigas Nakai?
It is best to follow the dosing schedule used in clinical trials until more specific recommendations are available.
What benefits can I expect from using this supplement?
Users may see benefits in lowering blood triglycerides and potentially in memory health and pain management, pending further confirmation from research.
Can Angelica gigas Nakai replace my medication?
No, it should not be used as a substitute for prescribed medical treatments and should be discussed with a healthcare professional.
Research Sources
- https://www.mdpi.com/1648-9144/59/12/2066 – This clinical trial demonstrated significant reductions in blood triglycerides in participants using Angelica gigas Nakai extract, highlighting its efficacy and need for further research in broader populations.
- https://www.mdpi.com/2227-9717/10/5/880 – This in vitro study reported the inhibitory effects of Angelica gigas Nakai on MAO-A, MAO-B, cholinesterases, and β-secretase, suggesting therapeutic potential for neurodegenerative conditions.
- https://pubmed.ncbi.nlm.nih.gov/35876033/ – A comprehensive review evaluating the anticancer and other bioactivities of Angelica gigas Nakai, noting its potential benefits based on preclinical studies while acknowledging the need for human research.
- https://www.mdpi.com/2072-6643/12/2/377 – This article explores the bioactivity of Angelica gigas Nakai, compiling evidence from various studies while highlighting gaps in research and possible future directions for investigation.
- https://www.cochranelibrary.com/content?templateType=related&urlTitle=%2Fcentral%2Fdoi%2F10.1002%2Fcentral%2FCN-00579383&doi=10.1002%2Fcentral%2FCN-00579383 – A systematic review addressing the safety profiles of various herbal supplements, briefly mentioning Angelica gigas Nakai, underscoring the importance of monitoring herbal interactions with conventional drugs.
