Angelica Glycerite Liquid Extract
Also known as: Angelica root, Dong Quai, Angelica sinensis, Korean Dang-gui, Angelica gigas Nakai, Angelica archangelica
Overview
Angelica glycerite liquid extract is an alcohol-free botanical preparation derived from the root of Angelica species, primarily Angelica archangelica, though related species like Angelica sinensis and Angelica gigas are also used. This extract utilizes vegetable glycerin as a solvent, preserving the plant's bioactive compounds through a low-temperature extraction process. Traditionally, Angelica species have been employed in herbal medicine for a range of conditions, including supporting liver health, modulating lipid metabolism, enhancing memory, managing pain, and improving growth performance. While traditional uses are widespread, high-quality human randomized controlled trials specifically on Angelica glycerite liquid extract are limited. The current body of research largely consists of in vitro studies, animal models, and some controlled trials on related Angelica extracts, particularly focusing on polysaccharides from Angelica sinensis and ethanolic extracts from Angelica gigas. Systematic reviews or meta-analyses specifically addressing the glycerite liquid extract form are not yet available, indicating a need for more targeted human clinical research.
Benefits
Preclinical research suggests several potential benefits of Angelica extracts, though specific evidence for the glycerite liquid extract form in humans is limited. Low molecular weight polysaccharides from Angelica sinensis have shown promise in modulating lipid metabolism, with studies indicating their potential to reduce triglycerides and cholesterol levels, ameliorate lipid accumulation in liver cells, and improve models of non-alcoholic fatty liver disease (NAFLD) in mice. This suggests a potential role in supporting liver health and metabolic function. Furthermore, ethanolic extracts of Angelica gigas have demonstrated neuroprotective effects in animal models of cerebral ischemia, where they helped preserve hippocampal neurons and cognitive functions, indicating a potential for memory and brain health support. In animal studies, Angelica archangelica extract supplementation has been linked to improved growth parameters and feed conversion ratios in rainbow trout, suggesting possible anabolic or metabolic benefits. Traditional uses of Angelica include pain management, memory support, and circulatory health, but these applications require more rigorous clinical validation in humans.
How it works
The mechanisms of action for Angelica extracts vary depending on the specific bioactive compounds present. Polysaccharides, particularly from Angelica sinensis, are believed to modulate lipid metabolism pathways by potentially reducing the synthesis or accumulation of triglycerides and cholesterol. This action may contribute to their observed effects on liver health and NAFLD models. Constituents found in Angelica gigas, such as decursinol and decursinol angelate, are thought to exert neuroprotective effects by inhibiting specific protein kinases and maintaining the integrity of the blood-brain barrier following ischemic events. This can help reduce neuronal death and inflammation in the brain. The glycerite extraction method is designed to preserve water-soluble bioactive compounds without the use of alcohol, which may influence the bioavailability and overall pharmacological profile of the extract compared to traditional ethanolic preparations.
Side effects
Angelica extracts are generally considered safe when used traditionally, but specific safety data for Angelica glycerite liquid extracts are sparse. In reviewed animal studies, no significant adverse effects were reported. However, it is important to note that Angelica species, in general, have been associated with potential interactions with anticoagulants due to their coumarin content, which can thin the blood and increase the risk of bleeding. Individuals with hormone-sensitive conditions should also exercise caution, as some Angelica species, particularly Angelica sinensis (Dong Quai), are known to have phytoestrogenic effects. These potential interactions and contraindications require further clinical confirmation specifically for the glycerite extract. The alcohol-free nature of glycerite extracts eliminates concerns related to ethanol content, making them a suitable option for individuals who wish to avoid alcohol. As with any supplement, it is advisable to consult a healthcare provider before use, especially if pregnant, nursing, or taking other medications, to assess individual risk and avoid potential adverse effects or interactions.
Dosage
There is currently no standardized dosing for Angelica glycerite liquid extract established through human clinical trials. Dosage recommendations are largely based on traditional herbal practices or extrapolated from preclinical animal studies, which used varying concentrations and forms of Angelica extracts. For instance, animal studies investigating neuroprotection used ethanolic extracts at doses ranging from 200-400 mg/kg in rodents. These dosages are not directly translatable to human use. Product labels for Angelica glycerite liquid extracts typically suggest a titrated approach, where users start with a small amount and gradually increase it based on individual response and the specific concentration of the extract. Due to the lack of robust human clinical data, it is crucial to adhere to the manufacturer's recommended dosage on the product label and consult with a healthcare professional for personalized guidance. There are no established upper limits or safety thresholds for Angelica glycerite liquid extract in humans, emphasizing the need for caution and professional advice.
FAQs
Is Angelica glycerite extract effective for liver health?
Preclinical studies suggest potential benefits for liver health, particularly in reducing lipid accumulation and improving NAFLD models in mice, due to polysaccharides from Angelica sinensis. However, human clinical trials are needed to confirm these effects.
Is it safe to use alcohol-free Angelica extracts?
Generally, alcohol-free glycerite extracts are considered safe, especially for those avoiding alcohol. However, individuals on medications, particularly anticoagulants, or with hormone-sensitive conditions should consult a healthcare provider due to potential interactions.
How soon can one expect to see effects from Angelica glycerite extract?
Animal studies show effects over weeks, but the timeline for human response is unknown due to a lack of human clinical trials. Effects may vary based on individual factors and the specific condition being addressed.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7382173/ – This preclinical study investigated low molecular weight polysaccharides from Angelica sinensis, demonstrating their ability to reduce triglycerides, cholesterol, and lipid accumulation in NAFLD mouse models and liver cells. The findings suggest potential as a therapeutic agent for non-alcoholic fatty liver disease, though human data are needed.
- https://www.agrojournal.org/26/01-30.pdf – This controlled animal feeding trial evaluated Angelica archangelica extract's effect on rainbow trout. Results showed significant improvements in live weight, weight gain, and feed conversion ratio in the treated group, indicating potential growth-promoting and metabolic benefits in an aquaculture setting.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11785709/ – This preclinical animal RCT explored the neuroprotective effects of Angelica gigas Nakai root ethanolic extract in a gerbil cerebral ischemia model. The study found that higher doses of the extract preserved hippocampal neurons, maintained blood-brain barrier integrity, and improved memory tests post-ischemia, suggesting neuroprotective potential.
