ANGELICA POLYMORPHA SINENSIS EXTRACT
Also known as: Angelica sinensis, Dong quai, Chinese angelica
Overview
Angelica sinensis, commonly known as Dong quai or Chinese angelica, is a plant native to China, particularly mountainous regions, and is widely used in traditional Chinese medicine. It is valued for its medicinal properties, primarily attributed to compounds like ferulic acid, Z-ligustilide, and polysaccharides. Traditionally, it has been used to address gynecological issues, support cardiovascular health, and act as an anti-inflammatory agent. Research on Angelica sinensis is ongoing, with studies exploring its pharmacological effects. While some studies are in vitro or animal-based, an increasing number of human clinical trials are being conducted to validate its benefits. The quality of available evidence varies, necessitating cautious interpretation and further rigorous investigation to confirm its efficacy and safety.
Benefits
Angelica sinensis is associated with several potential health benefits. It may improve cardiovascular health, reduce inflammation, and enhance immune function. Some research suggests it may have protective effects against certain cancers. Women with menstrual irregularities or menopausal symptoms may experience relief, although specific effect sizes are not well-documented and require further research. A systematic review and meta-analysis highlighted potential benefits in combination therapy for treating idiopathic pulmonary fibrosis. Additionally, a review indicated that Angelica sinensis may not increase breast cancer risk and could have positive effects when used alongside conventional treatments. More high-quality studies are needed to fully understand the benefits and risks.
How it works
Angelica sinensis exerts its effects through multiple biological pathways. It exhibits anti-inflammatory and antioxidant properties, and may also have estrogenic effects. The herb interacts with cardiovascular, immune, and reproductive systems. Compounds like Z-ligustilide may target pathways involved in apoptosis and DNA damage. However, the absorption and bioavailability of Angelica sinensis are not well-documented and may vary based on preparation methods. Further research is needed to fully elucidate its mechanisms of action and optimize its therapeutic use.
Side effects
Angelica sinensis is generally considered safe when used appropriately, but it can cause side effects in some individuals. Common side effects include gastrointestinal upset and allergic reactions. Uncommon side effects involve bleeding risks due to its anticoagulant properties. Rare side effects include severe allergic reactions. It may interact with anticoagulants and diabetes medications, potentially increasing the risk of bleeding or altering blood sugar levels. Angelica sinensis is contraindicated in pregnancy, breastfeeding, and individuals with certain bleeding disorders. Caution is advised in patients with bleeding risks or those taking anticoagulant medications. It is essential to consult with a healthcare provider before using Angelica sinensis, especially if taking other medications or having pre-existing health conditions.
Dosage
The minimum effective dose of Angelica sinensis is not well-established, and it is typically used in traditional doses. Optimal dosage ranges vary based on the preparation and the condition being treated. The maximum safe dose is not clearly defined, and caution is advised at high doses. It may be taken with meals to reduce gastrointestinal side effects. Angelica sinensis is often used as a decoction or in capsule form. Bioavailability may be affected by preparation methods. There are no specifically identified required cofactors. Consult a healthcare provider for personalized dosage recommendations.
FAQs
Is Angelica sinensis safe to use with other medications?
Angelica sinensis may interact with anticoagulants and diabetes medications. Consult a healthcare provider before use, especially if taking other medications, to avoid potential adverse effects.
How long does it take to see results from taking Angelica sinensis?
The time to notice effects from Angelica sinensis is variable and may take several weeks. Individual responses can differ, and it is important to consult a healthcare provider for realistic expectations.
Can Angelica sinensis be used as a substitute for medical treatment?
No, Angelica sinensis is not a substitute for medical treatment. Consult a healthcare provider for appropriate medical care and to determine if Angelica sinensis is a suitable complementary therapy.
What are the common side effects of Angelica sinensis?
Common side effects include gastrointestinal upset and allergic reactions. If you experience any adverse effects, discontinue use and consult a healthcare provider.
Who should avoid taking Angelica sinensis?
Angelica sinensis is contraindicated in pregnancy, breastfeeding, and individuals with certain bleeding disorders. Consult a healthcare provider if you have any pre-existing health conditions.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/40411686/ – This study explores the effects of Angelica sinensis on endometrial cancer, suggesting potential therapeutic benefits through network analysis. The research highlights the herb's potential role in cancer treatment, warranting further investigation into its specific mechanisms and clinical applications.
- https://pubmed.ncbi.nlm.nih.gov/32425767/ – This systematic review and meta-analysis examined the use of Radix Astragali and Radix Angelicae Sinensis in treating idiopathic pulmonary fibrosis. The findings suggest potential benefits in combination therapy, indicating that these herbs may improve outcomes for patients with this condition.
- https://www.xiahepublishing.com/m/2835-6357/FIM-2023-00002 – This review indicated that Angelica sinensis may not increase breast cancer risk and could have positive effects when used alongside conventional treatments. The study suggests that Angelica sinensis could be a beneficial adjunct to traditional cancer therapies, offering potential synergistic effects without increasing the risk of adverse outcomes.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1153583/full – This study investigates the protective effects of Angelica sinensis polysaccharides against myocardial ischemia-reperfusion injury. The research highlights the potential of these polysaccharides to reduce oxidative stress and inflammation, thereby protecting the heart during and after ischemic events.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1510976/full – This research explores the synergistic effects of Angelica sinensis and Astragalus membranaceus in treating pulmonary fibrosis. The study demonstrates that the combination of these herbs can effectively reduce lung inflammation and fibrosis, suggesting a promising therapeutic approach for pulmonary fibrosis management.
