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Angelica Root Extract

Also known as: Dong Quai, Chinese Angelica, Radix Angelicae Sinensis, Angelica sinensis

Overview

*Angelica sinensis* (Oliv.) Diels, commonly known as Dong Quai, is a herb native to China, widely utilized in Traditional Chinese Medicine (TCM). The roots of this plant are prized for their medicinal properties. Traditionally, it's used to alleviate menstrual cramps, symptoms of menopause, and certain cardiovascular diseases. Recent investigations have also delved into its potential efficacy in addressing idiopathic pulmonary fibrosis (IPF) and certain cancers. The root is rich in bioactive compounds, especially ligustilide, which is attributed to various health benefits. Although research includes traditional applications and some clinical studies, its efficacy and safety in humans require further validation through high-quality trials. Evidence quality varies; some studies show promising results, particularly for IPF, while the research on other conditions is less conclusive.

Benefits

*A. sinensis* offers several evidence-backed benefits. In particular, it has been reported to enhance pulmonary function and exercise tolerance in patients with IPF, as shown in a meta-analysis of 17 randomized controlled trials (RCTs) that noted significant improvements in various pulmonary metrics. Additionally, it may provide relief from menopause symptoms and menstrual cramps, though this data lacks rigorous validation. Preliminary studies also suggest possible anticancer properties, with sources indicating better outcomes for certain breast cancer patients when combined with drugs like tamoxifen. While the effects on IPF are well-documented, the benefits for other conditions are less clearly defined and require further investigation.

How it works

*A. sinensis* is theorized to work through multiple biological mechanisms. It exhibits anti-inflammatory, antioxidant, and vasodilatory properties, primarily mediated by ligustilide. Additionally, it may act on estrogen receptors, albeit with weak binding affinity. Its effects on the cardiovascular and respiratory systems suggest a broad impact, specifically enhancing circulation and potentially shielding lung tissue in IPF.

Side effects

Generally recognized as safe at traditional doses, *A. sinensis* may pose risks at elevated levels. Common side effects are relatively unknown, but an increase in blood pressure and associated heart problems at high doses have been reported. Drug interactions are possible, particularly with anticoagulants and medications that carry grapefruit warnings. Special caution is warranted for pregnant or breastfeeding women, as safety in these groups is not established. Patients with certain cancers, specifically breast cancer, should seek medical advice before use due to uncertain interactions with cancer therapies.

Dosage

No established minimum effective dose exists, but traditional use often cites a daily intake of 6-12 grams of dried root. Supplements typically contain 500-2000 mg per serving, without a well-defined optimal dosage. Doses exceeding 2000 mg may raise risks for adverse effects. There are no specific timing guidelines; *A. sinensis* can be used within routine daily practices. It comes in several forms, including capsules, liquid extracts, and dried tea, with choices depending on personal preference and results sought.

FAQs

Is *A. sinensis* safe to use?

*A. sinensis* is generally safe when taken at traditional doses. Caution is advised for high doses and certain populations, such as pregnant or breastfeeding women.

How should I take *A. sinensis*?

There are no set recommendations for timing, but it is usually taken daily. Forms include capsules, extracts, and teas according to preference.

What benefits can I expect from using *A. sinensis*?

It may improve pulmonary function in IPF patients and provide relief from menopause symptoms and menstrual cramps. However, the results can vary.

Can *A. sinensis* treat cancer?

Although early studies are promising regarding its anticancer properties, there is no conclusive evidence proving its efficacy in treating cancer in humans.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/32425767/ – A systematic review and meta-analysis of 17 RCTs found significant improvements in pulmonary function and exercise tolerance in IPF patients treated with *A. sinensis*.
https://www.healthline.com/nutrition/angelica-root – An overview of *A. sinensis*, covering its uses, benefits, and potential side effects, highlighting evidence from various studies albeit with limitations.
https://jmla.pitt.edu/ojs/jmla/article/download/1223/1368 – Discusses the potential anticancer effects of *A. sinensis* based on animal and test-tube studies, emphasizing the need for human trials to establish these effects.
https://www.xiahepublishing.com/2835-6357/FIM-2023-00002 – Investigates the applications of *A. sinensis* in conjunction with tamoxifen for breast cancer, noting both positive and negative outcomes in patients.
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.942188/full – This article examines the bioactive compounds in *A. sinensis*, particularly ligustilide, and their mechanisms of action in various health contexts.