Angelica Sinensis Root Extract
Also known as: Dong Quai, Danggui, Angelica sinensis
Overview
*Angelica sinensis* (Oliv.) Diels. is a perennial herb native to China, Japan, and Korea, commonly known as Dong Quai or Danggui. Widely utilized in traditional Chinese medicine, its root is particularly praised for addressing various women's health issues, including dysmenorrhea and amenorrhea. Beyond its historical applications, it has shown promise in modern research for conditions like osteoporosis and idiopathic pulmonary fibrosis (IPF). The root is rich in bioactive compounds including phthalides, ferulic acid, and polysaccharides, contributing to its therapeutic potential. Currently, the body of research is moderate, revealing potential health benefits but necessitating further rigorous clinical studies for validation. Considered generally safe when used appropriately, it's advised to consult with healthcare providers, especially for specific populations. Its preparations include dried root or extracts in capsules and teas.
Benefits
The benefits of *Angelica sinensis* include: - **Women's Health**: Traditionally utilized to alleviate dysmenorrhea and related reproductive issues, although quantifiable outcomes in clinical studies are limited. - **Osteoporosis**: Research indicates that *A. sinensis* extract can prevent bone loss in ovariectomized rats through estrogen-independent pathways, suggesting it may be beneficial for bone health. - **Idiopathic Pulmonary Fibrosis (IPF)**: A systematic review demonstrated that combining *A. sinensis* with *Radix Astragali* significantly improved pulmonary function and exercise tolerance among IPF patients. - **Renoprotection**: Evidence suggests dose- and time-dependent protective effects on renal health. These benefits are primarily observed in women needing reproductive support and patients suffering from IPF.
How it works
*Angelica sinensis* is believed to exert its effects through several biological pathways. It has antioxidant properties, reduces inflammation, and may act similarly to estrogen without significantly altering serum estradiol levels. The root's bioactive compounds, particularly ferulic acid and polysaccharides, are thought to interact with the circulatory and reproductive systems, which could explain the observed benefits in women's health. However, detailed molecular targets remain largely undefined, and data on human bioavailability is limited.
Side effects
The safety profile of *Angelica sinensis* is generally considered favorable when used correctly, but comprehensive data on long-term use remains sparse. Common side effects are not well-documented, with few studies reporting gastrointestinal upset (occurred in 1-5% of users). Rare adverse effects have not been extensively reported in peer-reviewed literature. There may be potential interactions with anticoagulants, given its effects on blood circulation, which necessitates caution in individuals with bleeding disorders or those taking blood-thinning medications. Contraindications also include pregnancy and breastfeeding due to the lack of safety evidence in these populations. Overall, while mostly safe, users should monitor for any adverse reactions and consult healthcare providers when including it in their regimen.
Dosage
The optimal dosage of *Angelica sinensis* has not been firmly established and can vary based on the specific condition being addressed. Traditional Chinese medicine often utilizes variable dosages in formulations without a standardized maximum. As such, a cautious approach is advised, particularly because the maximum safe dose is not clearly defined. Generally, the herb is consumed in the form of dried root, extract, or tea, with preparation method significantly influencing absorption. While the minimum effective dose remains uncertain, users should follow guidelines from qualified practitioners, especially in light of absorption variations caused by different forms and preparation methods.
FAQs
Can I use Dong Quai if I am pregnant or breastfeeding?
It's advised against using *Angelica sinensis* during pregnancy or breastfeeding due to insufficient safety data.
How does Dong Quai interact with medications?
It may interact with anticoagulant medications; consult a healthcare provider if you're on blood thinners.
What is the expected time frame for noticing benefits?
Benefits can vary; women may observe effects on dysmenorrhea relatively quickly, while benefits for conditions like IPF may take longer.
Is Dong Quai effective for all women’s health issues?
While traditionally used for reproductive issues, scientific support mainly surrounds specific conditions like dysmenorrhea; more research is needed.
Can I take Dong Quai with other supplements?
Consult a healthcare provider before combining with other supplements, particularly if you are on medication.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/32425767/ – A systematic review and meta-analysis examining the effects of *Angelica sinensis* combined with *Radix Astragali* on pulmonary function and exercise tolerance in IPF patients. It included 17 randomized controlled trials, highlighting significant improvements but noting variability in study quality.
- https://pubmed.ncbi.nlm.nih.gov/24365638/ – This animal study found that *Angelica sinensis* extract effectively prevented bone loss in ovariectomized rats, indicating a potential estrogen-independent mechanism, although further human studies are necessary.
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1153583/full – A retrospective analysis investigating the dose- and time-dependent renoprotective effects of *Angelica sinensis* in over 18,000 users, with results indicating positive renal benefits alongside potential biases inherent in retrospective designs.
- https://pubmed.ncbi.nlm.nih.gov/25325255/ – This study assessed the potential health benefits of *Angelica sinensis* and discussed its varying applications in traditional Chinese medicine, establishing its significance in reproductive health.
- https://taylorandfrancis.com/knowledge/Medicine_and_healthcare/Clinical_nutrition/Angelica_sinesis/ – An article summarizing the clinical uses of *Angelica sinensis*, focusing on its herbal applications, dosages, safety, and potential interactions in clinical nutrition.