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Arachidonic Acid

Also known as: ARA

Overview

Arachidonic acid (AA) is a fatty acid of the omega-6 class, and is the main fatty acid of interest when referring to an omega-3:6 ratio (relative to fish oil fatty acids). It is proinflammatory and immunosupportive.

Benefits

Arachidonic acid is a key component of cell membranes and plays a crucial role in the inflammatory response. It is released from membrane phospholipids and converted into various eicosanoids, which are signaling molecules that mediate inflammation and other physiological processes.

How it works

Arachidonic acid supplementation is often associated with benefits related to muscle growth, strength, and recovery. It may enhance anaerobic capacity, improve power output, and support testosterone levels, contributing to overall athletic performance.

Side effects

There is currently insufficient evidence to recommend an ideal dose of arachidonic acid supplementation, but anecdotally it is used at the dosage of around 2,000 mg taken 45 minutes before a workout. It is uncertain if this is an optimal dose or whether the timing is required. It should also be noted that for persons with chronic inflammatory disorders, such as rheumatoid arthritis or inflammatory bowel diseases, that the ideal dose of arachidonic acid may actually be a dietary restriction thereof. In instances of inflammatory diseases, arachidonic acid supplementation is likely contraindicated.

Dosage

Arachidonic acid supplementation may lead to increased inflammation in some individuals, particularly those with pre-existing inflammatory conditions. Safety concerns include potential exacerbation of conditions like rheumatoid arthritis or inflammatory bowel diseases.