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Artichoke Leaf Glycerite Liquid Extract

Also known as: Artichoke, Artichoke Leaf, Artichoke Leaf Extract, Cynara scolymus

Overview

Artichoke leaf extract, derived from the leaves of the *Cynara scolymus* plant, is a herbal supplement traditionally used for its medicinal properties. It is primarily recognized for its potential to lower cholesterol, improve liver health, and aid in digestion. The extract contains beneficial compounds like cynarin and silymarin, believed to contribute to its health benefits. Research indicates a moderate level of evidence supporting its lipid-lowering effects, with several studies, including systematic reviews and meta-analyses, confirming its cholesterol-lowering capabilities. Artichoke leaf extract is available in various forms, including capsules, tablets, and liquid extracts like glycerites. The glycerite form may offer an alternative for individuals who prefer liquid supplements or have difficulty swallowing pills. However, it's important to consider potential variations in concentration and bioavailability when using glycerite extracts.

Benefits

Artichoke leaf extract has demonstrated significant potential in reducing total and LDL cholesterol levels. A meta-analysis indicated an approximate reduction of 16.51 mg/dL in LDL-C levels (95% CI: -21.94, -11.08). This cholesterol-lowering effect is clinically significant, particularly for individuals with elevated baseline LDL-C levels. Secondary benefits may include reduced blood pressure and liver inflammation. These benefits are most pronounced in individuals with high cholesterol or those at risk of cardiovascular diseases. The positive effects can typically be observed within a few weeks of consistent use. The evidence supporting these benefits is generally of good quality, with systematic reviews and meta-analyses providing robust support.

How it works

Artichoke leaf extract is believed to influence lipid metabolism and liver function, potentially through the inhibition of the mitochondrial respiratory chain. It interacts with both the cardiovascular and hepatic systems. Compounds like cynarin may act on specific enzymes involved in lipid metabolism, contributing to its cholesterol-lowering effects. While the exact mechanisms are still under investigation, the extract's interaction with these biological pathways suggests a multi-faceted approach to improving lipid profiles and supporting liver health. The bioavailability of artichoke leaf extract is not extensively studied, but it is believed to be absorbed in the gastrointestinal tract.

Side effects

Artichoke leaf extract is generally considered safe when used appropriately. Common side effects, occurring in more than 5% of users, include gastrointestinal upset such as nausea or bloating. Uncommon side effects, affecting 1-5% of users, may involve allergic reactions. Rare side effects, seen in less than 1% of users, could include severe allergic reactions. There is potential for interactions with cholesterol-lowering medications. It is contraindicated during pregnancy and breastfeeding due to insufficient safety data. Caution is advised for individuals with known allergies to artichokes or related plants. It is important to start with a low dose to assess tolerance and to monitor for any adverse reactions. Individuals with pre-existing liver or gallbladder conditions should consult with a healthcare professional before using artichoke leaf extract.

Dosage

The minimum effective dose of artichoke leaf extract is typically around 500-1000 mg per day. Optimal dosage ranges are generally between 500-1500 mg per day. The maximum safe dose is not well established, but doses above 1500 mg per day are not commonly recommended. It is best taken with meals to minimize gastrointestinal side effects. For glycerite liquid extracts, more frequent dosing may be required due to potential variability in concentration. Absorption may be enhanced by taking it with fatty meals. There are no specifically identified required cofactors. It is important to adhere to recommended dosage guidelines and consult with a healthcare professional for personalized advice.

FAQs

How often should I take artichoke leaf extract?

Typically, it is recommended to take it 2-3 times a day with meals to minimize gastrointestinal side effects and optimize absorption.

Is artichoke leaf extract safe during pregnancy?

No, artichoke leaf extract is not recommended during pregnancy due to insufficient safety data. It is best to avoid use during pregnancy and breastfeeding.

When is the best time to take artichoke leaf extract?

It is best taken with meals to reduce potential side effects and enhance absorption of its beneficial compounds.

How long does it take to see results from taking artichoke leaf extract?

Noticeable cholesterol reduction may be observed within a few weeks of consistent use, but individual results may vary.

Is artichoke leaf extract a substitute for medical treatment?

No, it is not a substitute for medical treatment but can be used as a complementary therapy under the guidance of a healthcare professional.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/28609140/ – This study investigated the effects of artichoke leaf extract on lipid profiles. The results indicated a significant reduction in total cholesterol and LDL cholesterol levels in participants taking the extract, suggesting its potential as a natural remedy for hyperlipidemia.
https://pubmed.ncbi.nlm.nih.gov/33465383/ – This research explored the impact of artichoke leaf extract on liver health. The findings suggested that the extract may have hepatoprotective properties, potentially reducing liver inflammation and improving overall liver function.
https://www.verywellhealth.com/can-artichoke-leaf-extract-lower-cholesterol-698105 – This article provides an overview of the potential cholesterol-lowering benefits of artichoke leaf extract. It highlights the active compounds in the extract and summarizes the findings of various studies supporting its use in managing cholesterol levels.
https://academy.miloa.eu/wp-content/uploads/2020/04/A.-Sahebkar-A.-F.-Cicero-al-2017-3.pdf – This meta-analysis of randomized controlled trials examined the effect of artichoke leaf extract on blood lipids. The analysis revealed a significant reduction in total and LDL cholesterol levels, supporting the use of artichoke leaf extract as a complementary therapy for managing hypercholesterolemia.
https://www.science.gov/topicpages/a/artichoke+leaf+extract.html – This resource provides a compilation of scientific research related to artichoke leaf extract. It covers various aspects, including its chemical composition, potential health benefits, and mechanisms of action, offering a comprehensive overview of the available scientific literature.