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AstraGin Root Extract

Also known as: Astragalus, Huang Qi, Milk Vetch, *Astragalus membranaceus*

Overview

Astragalus membranaceus is a herbaceous plant native to regions of East Asia including China, Mongolia, and Korea. It has been utilized in traditional Chinese medicine (TCM) for centuries, primarily known for its immune-boosting properties and various health benefits. The herb is rich in active compounds, including polysaccharides, flavonoids, and saponins, which are believed to confer immunomodulatory and antioxidant effects. Astragalus is commonly used in herbal formulations aimed at enhancing immune function, managing diabetic complications, and serving as a supportive therapy in cancer treatments. Research on its efficacy is well-documented, showing moderate to high levels of evidence from both clinical trials and meta-analyses, although certain studies display methodological limitations.

Benefits

The primary benefit of *Astragalus membranaceus* is its role in immunomodulation, as evidenced by a systematic review indicating significant enhancement in cellular and humoral immune responses, with increases in immunoglobulin levels (IgG, IgA, IgM) and cytokines like interleukin-2 (IL-2). For diabetic nephropathy, a meta-analysis has shown significant improvements in clinical outcomes, such as reduced urinary albumin excretion rate (UAER) and better renal function when combined with Panax notoginseng. In cancer, the use of Astragalus in conjunction with chemotherapy has been linked to improved tumor response rates and mitigation of side effects. In animal studies, Astragalus has been shown to enhance growth performance and antioxidant capacity in young livestock. Overall, individuals suffering from diabetes or undergoing cancer treatment may experience the most substantial benefits.

How it works

The mechanism of action of *Astragalus membranaceus* primarily involves its immunomodulatory effects, enhancing both humoral and cellular immune responses by increasing the production of immunoglobulins and cytokines. It may interact with inflammatory pathways, contributing to its antioxidant properties and support for renal function in patients with diabetic complications. Additionally, Astragalus compounds exhibit good bioavailability when administered orally, promoting systemic effects that reinforce immune health and modulate inflammation.

Side effects

Generally, *Astragalus membranaceus* is well-tolerated with a favorable safety profile. Common side effects (occurring in less than 5% of users) are not consistently reported in the literature, and there are no significant adverse effects noted in systematic reviews. Uncommon side effects may exist but are not well-documented, and rare side effects appear to be negligible in available studies. Potential drug interactions may occur with immunosuppressive medications; therefore, caution is advised in individuals on such therapies or those with autoimmune conditions. Pregnant or breastfeeding women should exercise caution due to limited safety data.

Dosage

The recommended dosage of *Astragalus membranaceus* varies depending on the intended use. For immune modulation, effective doses are typically in the range of 2-4 grams of the root extract per day. In combination treatments for diabetic nephropathy, specific dosage recommendations have not been standardized but should be used as part of a larger herbal formula. A common practice involves taking the herb with meals to enhance absorption. While high doses above 10 grams per day are not commonly researched, no established maximum safe dose exists, but users are encouraged to follow traditional dosing guidelines and monitor for effects.

FAQs

Is *Astragalus membranaceus* safe for everyone?

While generally safe, caution is advised for those with autoimmune diseases or on immunosuppressive medications. Pregnant or breastfeeding women should consult a healthcare professional.

How should I take *Astragalus membranaceus*?

It can be taken as a root extract, decoction, or capsules. Taking it with meals may enhance absorption.

What results can I expect from using *Astragalus*?

Users can expect improvements in immune and renal function, particularly in those with diabetes or undergoing chemotherapy.

Can *Astragalus* cure diseases?

It is not a cure-all and should be used under medical guidance, especially when combined with other treatments.

Research Sources

https://onlinelibrary.wiley.com/doi/10.1155/2023/2945234 – This systematic review evaluates the effect of *Astragalus membranaceus* on diabetic nephropathy, indicating its ability to significantly improve renal outcomes and reduce urinary albumin excretion in patients.
https://pubmed.ncbi.nlm.nih.gov/32608134/ – A meta-analysis examining *Astragalus*-containing herbal medicine found statistically significant improvements in tumor response and quality of life indicators among women undergoing treatment for cervical cancer.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.587021/full – This controlled trial assessed growth performance in yak calves and concluded that *Astragalus* supplementation resulted in enhanced immunity and growth metrics over a 60-day period.
https://karger.com/cmr/article-abstract/30/6/535/869772/The-Effect-of-Astragalus-on-Humoral-and-Cellular?redirectedFrom=fulltext – The article discusses the immune-enhancing capabilities of *Astragalus membranaceus*, reporting significant increases in humoral and cellular immunity markers following supplementation.
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/astragalus – Investigative review on *Astragalus*, highlighting its applications, benefits, and safety profiles, particularly in immunocompromised populations.