ProveIt Supplements

Independent, evidence-based supplement analysis.

✓ Not Sponsored

✓ No Paid Reviews

✓ Science-Based

Company

  • About Us
  • Our Methodology
  • Contact
  • Blog
  • Authors

Legal

  • Privacy Policy
  • Terms of Service
  • Medical Disclaimer
  • Affiliate Disclosure

Resources

  • All Categories
  • Ingredient Database
  • Browse Supplements
  • FAQ

© 2025 ProveIt Supplements. All rights reserved.

Medical Disclaimer: The information provided is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen.

Prove It
Browse SupplementsBlogAuthorsAboutMethodologyFAQ
Get Your Personalized Supplement StackSupplement Stack Quiz
Menu
HomeBrowse SupplementsBlogAuthorsAboutMethodologyFAQ
Back

Astrgalus Root Extract

Also known as: Astragalus, Huang Qi, *Astragalus membranaceus*

Overview

Astragalus root extract is derived from the *Astragalus membranaceus* plant, a staple in traditional Chinese medicine known for its use as a general tonic and in the treatment of various health conditions. This herb is predominantly recognized for its immune-enhancing and anti-inflammatory properties. Research into Astragalus is growing, with moderate support for its health benefits, although there is a need for more rigorous clinical trials to ascertain its efficacy and safety. The extract is typically consumed in forms such as capsules, teas, and tinctures. Key bioactive compounds, like Astragaloside IV, contribute to its therapeutic effects. It is frequently used to support immune function, particularly in the context of cancer treatment and heart health, making it a popular choice among herbal supplements.

Benefits

Astragalus root extract offers a range of evidence-based benefits, particularly in enhancing immune function and mitigating chemotherapy side effects. In a systematic review, Astragalus-containing Chinese herbal medicine (CHM) significantly improved tumor response rates in cervical cancer patients (risk ratio: 1.25, 95% CI: 1.17–1.33). Furthermore, preliminary evidence suggests cardiovascular benefits, where it has been shown to improve left ventricular remodeling in heart failure patients, evidenced by a mean difference in ejection fraction of 5.82 (95% CI: 4.61 to 7.03). Animal studies also indicate that supplementation can enhance growth and immunity in early weaned yak calves, exhibiting effectiveness in both human and animal populations. Despite the promising findings, it is important to note that the quality of trials varies and further research is warranted to confirm these benefits.

How it works

The mechanism of action of Astragalus root extract encompasses various biological pathways, primarily through its anti-inflammatory and antioxidant properties. Key components such as Astragaloside IV are known to modulate immune responses by enhancing cytokine production and influencing immune cell activity. This modulation is crucial for improving immune defense and reducing inflammation. However, data on absorption and bioavailability is still limited, indicating a need for more extensive studies to understand how effectively these compounds interact within the body.

Side effects

Astragalus root extract is generally regarded as safe for most individuals when used appropriately, with mild side effects being the most commonly reported, primarily gastrointestinal disturbances such as nausea or diarrhea. Less frequently, allergic reactions may occur, warranting caution in individuals with known allergies to similar plants. Potential interactions have been noted with immunosuppressants and blood thinners, highlighting the necessity of consulting healthcare providers prior to use, especially for those on such medications. There is limited information on rare side effects as they are typically not well-documented; thus, pregnant and breastfeeding individuals should avoid the supplement due to insufficient safety data. Caution is particularly advised in populations with autoimmune conditions, where the immune-modulating properties may pose risks.

Dosage

While the minimum effective dose of Astragalus root extract is not thoroughly established, general recommendations suggest an optimal daily intake ranging from 500 mg to 2 grams. It is advised to take the supplement with meals to minimize potential gastrointestinal discomfort. Common forms of consumption include capsules and teas, each having varying bioavailability; consuming them with food may enhance absorption. The maximum safe dosage has not been firmly defined, emphasizing the importance of individual assessment and professional guidance. Regular monitoring for efficacy and safety is recommended, particularly in the context of long-term use.

FAQs

Is Astragalus safe to take with other medications?

It's important to consult a healthcare provider before taking Astragalus, especially with immunosuppressants or blood thinners, to avoid potential interactions.

What are the side effects of Astragalus?

Common side effects include mild gastrointestinal symptoms. Monitor for rare allergic reactions, especially if you have plant allergies.

When is the best time to take Astragalus?

Taking Astragalus with meals can help reduce gastrointestinal upset and improve absorption.

Can Astragalus replace conventional medicine?

No, Astragalus should not be considered a substitute for conventional medical treatment but rather a complementary therapy under professional supervision.

How long does it take to see results from Astragalus?

Results vary based on health conditions; some may notice improvements within weeks, while others may require longer durations.

Research Sources

  • https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.587021/full – This systematic review and meta-analysis involving 1,649 patients demonstrated that Astragalus-containing Chinese herbal medicine significantly improved tumor response and reduced chemotherapy toxicity in cervical cancer patients. However, it highlighted the low quality of many included studies.
  • https://pubmed.ncbi.nlm.nih.gov/32608134/ – This randomized controlled trial showed that Astragalus root extract improved growth performance and immunity in early weaned yak calves over a 60-day period. While the findings are promising, the sample size was small, limiting broader applicability.
  • https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1345797/full – This systematic review evaluated the effects of *Astragalus membranaceus* in heart failure patients, indicating improvements in left ventricular remodeling. The overall quality of included studies was moderate, suggesting further investigation is needed.