Atractylodes Lancea Extract
Also known as: Atractylodes lancea, Atractylodis rhizoma
Overview
Atractylodes lancea is a plant traditionally used in Chinese medicine, primarily for its rhizomes, which are rich in bioactive compounds. These compounds include sesquiterpenes, polysaccharides, and atractylodin. It is commonly employed in traditional practices to address various conditions, including digestive issues and inflammation. While there is some research exploring its potential health benefits, particularly in the context of traditional medicine, the overall maturity level of scientific research is moderate. Most studies are observational or small-scale, and there is a notable lack of high-quality clinical trials, systematic reviews, or meta-analyses. Despite its long history of traditional use, comprehensive scientific evidence supporting its efficacy and safety in modern medical contexts is still developing.
Benefits
Research suggests that Atractylodes lancea may offer several potential benefits, though the evidence quality varies. There is some indication it could help alleviate symptoms of colorectal cancer and improve outcomes when used as an adjunct therapy, as suggested by a study focusing on its role in inhibiting cancer progression. Another area of promise is its potential to reduce fatty liver and insulin resistance by activating the AMPK pathway, a key regulator of energy metabolism. Furthermore, Atractylodes lancea may possess anti-inflammatory and antiviral properties, which could be beneficial in conditions such as acute lung injury. Some studies also suggest benefits for specific populations, like patients undergoing chemotherapy, where it might help reduce nausea and vomiting. However, specific effect sizes and the time course for these benefits are not well-documented, and the majority of supporting evidence comes from observational or small-scale studies, limiting the strength of these claims.
How it works
Atractylodes lancea exerts its effects primarily through the activation of the AMPK signaling pathway. This pathway is crucial for regulating energy metabolism and plays a role in conditions like fatty liver and insulin resistance. The plant's bioactive compounds, such as atractylodin, are believed to interact with various molecular targets within the body, influencing metabolic processes and potentially modulating immune responses. While the exact molecular targets are not fully elucidated, the interaction with the AMPK pathway suggests a mechanism related to cellular energy balance and metabolic health. Information regarding the absorption and bioavailability of Atractylodes lancea compounds in the human body is currently limited.
Side effects
Atractylodes lancea is generally considered safe based on its long history of traditional use; however, comprehensive scientific data on its safety profile are limited. There is a lack of well-documented common, uncommon, or rare side effects in the available literature. Potential interactions with other medications have not been thoroughly studied, and no specific contraindications have been identified. Special caution is advised for pregnant or breastfeeding women due to the absence of sufficient safety data in these populations. Users should be aware that while traditional use suggests safety, the lack of rigorous clinical trials means that the full spectrum of potential adverse effects and drug interactions is not yet understood. It is always recommended to consult a healthcare professional before using Atractylodes lancea, especially if taking other medications or if pregnant/breastfeeding.
Dosage
Specific dosage guidelines for Atractylodes lancea are not well-established in modern scientific literature, as it is primarily used in traditional medicine preparations where dosages can vary widely. There is no clearly defined minimum effective dose, optimal dosage range, or maximum safe dose. Timing considerations for administration are also not specified. It is often consumed as a decoction or in combination with other herbs as part of traditional formulations. Information regarding absorption factors or required cofactors for its efficacy is limited. Due to the lack of standardized dosing and comprehensive safety data, individuals interested in using Atractylodes lancea should seek guidance from a qualified healthcare practitioner experienced in traditional medicine.
FAQs
Is Atractylodes lancea safe to use?
While traditionally used, comprehensive scientific safety data are lacking. It's generally considered safe based on historical use, but potential side effects and drug interactions are not well-documented. Consult a healthcare professional before use.
How should Atractylodes lancea be administered?
In traditional medicine, it's often used as a decoction or combined with other herbs. Specific modern administration guidelines are not established, and dosages vary based on traditional formulations.
What are the expected results from taking Atractylodes lancea?
Benefits are largely anecdotal or supported by preliminary research, not high-quality clinical trials. It's traditionally used for digestive issues and inflammation, with some studies suggesting benefits for fatty liver and cancer support.
Can Atractylodes lancea interact with other medications?
Potential drug interactions are not well-studied. It is crucial to consult a healthcare professional before using Atractylodes lancea, especially if you are taking any other medications, to avoid unforeseen interactions.
Is Atractylodes lancea a substitute for medical treatment?
No, Atractylodes lancea is not a substitute for conventional medical treatment. It should only be used as a complementary approach and always under the guidance of a healthcare provider, especially for serious conditions.
Research Sources
- https://www.aging-us.com/article/206075/text – This study investigates the potential role of Atractylodes lancea in inhibiting colorectal cancer progression. While it suggests a possible benefit, the research indicates that specific mechanisms and further clinical trials are needed to confirm its efficacy in this area.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11535289/ – This research demonstrates that Atractylodes lancea and its active compound, atractylodin, can alleviate fatty liver and insulin resistance. The study attributes these effects to the activation of the AMPK signaling pathway, highlighting a potential metabolic benefit.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9781712/ – This source discusses the anti-inflammatory and antiviral properties of Atractylodis rhizoma (related to Atractylodes lancea). It suggests that these properties could be beneficial in managing conditions such as acute lung injury, indicating a broader therapeutic potential.