Atractylodes Lancea Rhizome Extract
Also known as: Cangzhu, Atractylodes lancea rhizome, *Atractylodes lancea*
Overview
*Atractylodes lancea* is a medicinal plant widely utilized in traditional Chinese medicine, predominantly for its rhizomes, which are rich in bioactive compounds such as sesquiterpenoids. This herb has been traditionally employed to address various health issues including gastrointestinal disorders, rheumatic diseases, and influenza. Modern research has begun to validate its traditional uses, particularly its anti-inflammatory, anti-cancer, and anti-viral properties. Significant constituents include atractylodin and atractylone, which contribute to its pharmacological effects. While research on *Atractylodes lancea* is growing, most studies are preclinical or based on animal models, with limited clinical trials available to substantiate its efficacy in humans.
Benefits
Evidence suggests that *Atractylodes lancea* exhibits anti-inflammatory and anti-cancer properties, as demonstrated in preclinical studies. For example, luteolin derived from this plant has been shown to inhibit colorectal cancer cell proliferation. Additionally, its traditional applications for digestive issues and influenza suggest potential benefits for patients suffering from these conditions. However, while these effects are promising, the quantification of effect sizes or clinical significance is not well established in human studies, indicating a need for further research to definitively ascertain its therapeutic benefits.
How it works
The anti-cancer effects of *Atractylodes lancea* are thought to involve the PI3K/AKT signaling pathway, while its anti-inflammatory activities may be mediated through the MAPK and NF-κB pathways. By modulating these pathways, the bioactive compounds in this plant can influence various biological responses, including the reduction of cell proliferation and inflammatory factor levels. Notably, certain molecular targets such as MMP3, MMP9, and VEGFA have been identified, although detailed studies on absorption and bioavailability remain lacking.
Side effects
While *Atractylodes lancea* is generally considered safe when used traditionally, detailed safety data are absent. The most commonly reported side effect is gastrointestinal upset, although this is not well documented in literature. Rare and uncommon side effects remain unknown due to limited clinical investigation. Caution is advised for individuals on medications that affect the PI3K/AKT pathways, and it is contraindicated in pregnant and lactating women due to insufficient safety information. Additionally, special populations such as those with compromised liver or kidney function should use this supplement with caution.
Dosage
The optimal dosage of *Atractylodes lancea* remains unestablished, primarily due to a lack of standardized dosing recommendations for extracts. Traditionally, it is used in decoctions, although specific dosages for different preparations vary. Factors influencing absorption and bioactivity, including the form of the extract, further complicate dosage considerations. Given the current state of evidence, no maximum safe dose has been determined, and it is advisable to consult healthcare professionals when integrating this supplement into a health regimen.
FAQs
Is *Atractylodes lancea* safe to use?
Generally considered safe when used traditionally, *Atractylodes lancea* lacks comprehensive safety data, so consulting a healthcare provider is recommended.
Can it be used alongside medications?
Potential interactions with drugs that affect specific signaling pathways may occur, so it’s best to consult a healthcare professional before use.
What are the recommended ways to take it?
Traditional usage typically involves decoctions; specific dosage forms and methods vary according to preparation.
What conditions can it help with?
It's traditionally used for gastrointestinal issues and rheumatic diseases; ongoing research suggests potential anti-cancer benefits.
Is it effective for everyone?
Effects may vary by individual and condition. Evidence from human studies is limited, with more research needed.
Research Sources
- https://www.aging-us.com/article/206075/text – This study utilized network pharmacology to investigate the anti-cancer effects of luteolin in *Atractylodes lancea*, showing significant inhibition of colorectal cancer cell proliferation through interactions with specific genes.
- https://pubmed.ncbi.nlm.nih.gov/32987126/ – A review discussing various phytochemicals found in *Atractylodes lancea*, including sesquiterpenoids, and outlining their potential pharmacological activities, notably anti-inflammatory and anti-viral effects.
- https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2023.1237800/full – Research demonstrating that atractylenolide from *Atractylodes lancea* effectively reduces inflammatory factors by regulating the MAPK and NF-κB pathways.
- https://pubmed.ncbi.nlm.nih.gov/29329647/ – This publication provides insights into the traditional uses of *Atractylodes lancea* and outlines various leading researchers' findings regarding its pharmacological effects.
- https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1518433/full – A study evaluating the overall safety and efficacy of herbal supplements, including *Atractylodes lancea*, highlighting the need for more systematic reviews and clinical trials.