Atractylodes Macrocephala Extract
Also known as: Baizhu, White Atractylodes, *Atractylodes macrocephala*
Overview
*Atractylodes macrocephala* is a perennial herb native to the mountainous regions of China, widely recognized in Traditional Chinese Medicine (TCM) for its therapeutic properties. Known for its bioactive compounds such as sesquiterpenoids and triterpenoids, the extract is traditionally used to address various ailments including gastrointestinal issues, cancer support, arthritis, and osteoporosis. Despite its historical application, modern research on its pharmacological effects is growing, although it remains at a moderate maturity level. Clinical findings suggest potential benefits primarily related to cancer treatment and gastrointestinal health, though randomized controlled trials are necessary to confirm its efficacy and establish dosage guidelines.
Benefits
Research indicates several potential benefits of *Atractylodes macrocephala* extract, specifically in the context of cancer treatment. One prominent study found that when used alongside neoadjuvant chemotherapy in advanced gastric cancer patients, it significantly enhanced the overall response rate (RR: 1.41, 95% CI: 1.27-1.57) and disease control rate (RR: 1.20, 95% CI: 1.13-1.27). Furthermore, it improved patients’ quality of life (RR: 1.43, 95% CI: 1.30-1.57) by reducing adverse effects from chemotherapy. Additional benefits appear in its role in supporting gastrointestinal health, particularly in managing constipation through the regulation of gut microbiota. Most research has focused on Chinese populations, and the clinical significance of these findings underscores the need for further high-quality studies.
How it works
*Atractylodes macrocephala* demonstrates various biological activities, including anti-tumor, anti-inflammatory, and immunomodulatory effects. The plant enhances immune function by elevating T-cell counts and exerts effects via its bioactive compounds, such as polysaccharides and sesquiterpenoids. These compounds are believed to interact with multiple biological pathways, although specific molecular targets remain to be fully delineated. Additionally, its beneficial effects on gut health highlight its ability to influence the microbiome, although more detailed pharmacokinetic information is scarce.
Side effects
The safety profile of *Atractylodes macrocephala* is generally regarded as favorable, particularly within the context of TCM; however, comprehensive safety data remain limited. Reported common side effects (>5%) are not well-documented, while uncommon gastrointestinal disturbances might occur in about 1-5% of users. Rare side effects (<1%) have not been systematically reported. Caution is advised regarding potential interactions with chemotherapy drugs, especially as thorough research has not been performed on these interactions. Contraindications are not well-defined, and the use of this herb in vulnerable populations, such as pregnant women and children, has not been well-studied.
Dosage
Currently, precise dosing guidelines for *Atractylodes macrocephala* are not firmly established due to a lack of standardized peer-reviewed literature. Generally, it is utilized in combination with other herbs in TCM, which can lead to variability in recommended dosages. While optimal dosages may vary, practitioners often incorporate this herb into comprehensive treatment regimens, particularly alongside chemotherapy. Oral administration is the common form used, and while specific dosage amounts are not confirmed, being under the guidance of a healthcare provider is advisable due to the lack of established safe upper limits.
FAQs
Is *Atractylodes macrocephala* safe to use with other treatments?
While it is commonly used alongside other therapies, safety data regarding interactions, especially with Western medications, are limited. Consultation with a healthcare professional is recommended.
What benefits can I expect from using this extract?
Users often report improved cancer treatment outcomes and enhanced quality of life, though results can vary and more research is needed for conclusive evidence.
How should I take *Atractylodes macrocephala*?
It is primarily administered orally, often as part of combined herbal formulations; specific dosing should be tailored to individual treatment plans.
Are there specific populations that should avoid this supplement?
Limited data exist on its safety for pregnant women or children; caution is advised for these groups until more research is available.
What are common misconceptions about *Atractylodes macrocephala*?
A frequent misconception is that it can act as a standalone treatment without supporting evidence; high-quality studies are still needed to confirm its efficacy.
Research Sources
- https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1431381/full – This systematic review and meta-analysis assessed the effect of *Atractylodes macrocephala* on advanced gastric cancer, finding significant improvements in response rates and disease control when combined with neoadjuvant chemotherapy.
- https://pubmed.ncbi.nlm.nih.gov/30130541/ – This review outlines multiple pharmacological activities of *Atractylodes macrocephala*, emphasizing its anti-inflammatory and anti-tumor effects, while noting a lack of specific clinical trial data supporting its efficacy.
- https://pubmed.ncbi.nlm.nih.gov/39479020/ – This animal study explored the effects of polysaccharides derived from *Atractylodes macrocephala* on gastrointestinal health, demonstrating its potential to improve constipation via microbiota regulation.
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