Availom High Dha Omega 3 Lysine Complex
Also known as: AvailOm® High DHA Omega-3 Lysine Complex, Omega-3 lysine complex, Omega-3 polyunsaturated fatty acids (PUFAs) complexed with L-lysine amino acid
Overview
AvailOm is a novel omega-3 supplement formulation that complexes omega-3 fatty acids (EPA and DHA) with the amino acid L-lysine, forming a solid lysine salt. This innovative approach aims to significantly improve the stability and bioavailability of omega-3s compared to traditional oil-based ethyl ester or triglyceride forms. Sourced from purified omega-3 fatty acids combined with L-lysine, it results in a powder form known for enhanced oxidative stability and superior absorption. While research is still emerging, initial human pharmacokinetic studies and preclinical vascular function studies have been published, indicating its potential for cardiovascular health support and more efficient omega-3 delivery. Its primary advantage lies in its ability to deliver higher plasma omega-3 levels, potentially allowing for lower dosing.
Benefits
AvailOm demonstrates significantly higher bioavailability of EPA and DHA, with a reported 5-fold increase in plasma omega-3 levels compared to standard oil-based ethyl ester formulations in humans. This improved absorption suggests that lower doses may be sufficient to achieve therapeutic omega-3 blood levels. Preclinical studies in mice indicate dose-dependent vasorelaxation via AMPK-eNOS signaling, suggesting potential cardiovascular benefits. The combination with vasoactive anthocyanins further enhances vascular protection against oxidative stress and endothelial dysfunction. While clinical trials in specific populations are pending, AvailOm could be particularly beneficial for individuals requiring enhanced omega-3 uptake, such as those with malabsorption or cardiovascular risk factors. The 5-fold increase in bioavailability observed in human studies is statistically significant (p < 0.05). Absorption is rapid, though long-term clinical outcome data are not yet available.
How it works
The complexation of omega-3 fatty acids with L-lysine forms a stable salt, which enhances chemical stability and prevents oxidative degradation and rancidity. This complex significantly improves the solubility and absorption of EPA and DHA within the gastrointestinal tract, leading to higher plasma concentrations. In vascular tissue, the omega-3 lysine complex induces vasorelaxation by activating AMP-activated protein kinase (AMPK) and endothelial nitric oxide synthase (eNOS), which in turn increases nitric oxide production. The omega-3 ethyl ester derivative within the complex is identified as the primary bioactive component responsible for mediating these vascular effects.
Side effects
A 14-day repeated dose toxicity study in rats showed no adverse effects at doses up to 5% omega-3 lysine complex, and no human safety concerns have been reported in the available pharmacokinetic study. Common side effects typically associated with omega-3 supplements, such as mild gastrointestinal discomfort or a fishy aftertaste, may be reduced with AvailOm due to its improved stability and reduced oxidation. While no specific drug interactions or contraindications for AvailOm have been documented, standard omega-3 precautions apply, particularly regarding potential bleeding risk when combined with anticoagulants. Safety in special populations, including pregnant, nursing, or pediatric individuals, has not been specifically studied.
Dosage
The human bioavailability study utilized doses comparable to standard omega-3 supplementation, yet demonstrated significantly higher plasma EPA/DHA levels, suggesting the potential for achieving desired effects at lower doses. Optimal dosing for AvailOm has not yet been definitively established. Typical omega-3 doses range from 250 mg to 1 gram of EPA+DHA daily; AvailOm may achieve similar benefits at reduced dosages due to its enhanced absorption. AvailOm is a powder form suitable for various delivery systems, and its absorption is rapid. The lysine complexation inherently enhances absorption, and no additional cofactors are reported as necessary for its efficacy.
FAQs
Does it reduce fishy burps?
Yes, the improved oxidative stability of AvailOm helps reduce rancidity and the common fishy aftertaste often associated with traditional omega-3 oils.
How fast does it work?
AvailOm exhibits rapid absorption, leading to quicker increases in plasma omega-3 levels compared to conventional omega-3 forms.
Can it replace standard omega-3 supplements?
Potentially yes, especially when enhanced bioavailability is desired, but further clinical outcome data are needed to confirm its full efficacy as a replacement.
Research Sources
- https://healthcare.evonik.com/en/first-in-human-study-confirms-evoniks-availom-omega-3-lysine-complex-has-significantly-higher-bioava-151769.html – This source summarizes the findings of a randomized crossover pharmacokinetic study (Witkamp et al., 2020) which demonstrated that AvailOm omega-3 lysine complex achieved 5 times higher bioavailability of EPA/DHA compared to a standard oil-based ethyl ester formulation in healthy adults. The study highlights the significant improvement in omega-3 absorption with this novel complex.
- https://www.nutritionaloutlook.com/view/study-demonstrates-high-bioavailability-of-availom-omega-3-lysine-complex – This article discusses the results of a human study confirming the high bioavailability of AvailOm omega-3 lysine complex. It emphasizes the significant increase in plasma omega-3 levels achieved with AvailOm, suggesting its potential for more efficient delivery of EPA and DHA to the body.
- https://www.evonik.com/content/dam/evonik/documents/evonik-brochure-availom-scientific-overview.pdf.coredownload.pdf – This brochure provides a scientific overview of AvailOm, including preclinical toxicity data. It reports on a 14-day repeated dose toxicity study in rats showing no adverse effects at high doses, and highlights the improved oxidative stability of AvailOm compared to traditional omega-3 ethyl esters, contributing to its safety profile.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9137587/ – This peer-reviewed article (Di Pietro et al., 2022) details a preclinical vascular function study using an animal model. It demonstrates that AvailOm induced dose-dependent vasorelaxation via AMPK-eNOS signaling and showed protective effects against oxidative stress, suggesting potential cardiovascular benefits. The study also notes enhanced effects when combined with anthocyanins.
- https://nutraceuticalbusinessreview.com/omega-3-fatty-acid-lysine-complex-for-improved-stability-and-bioavailability-142819 – This source discusses the benefits of the omega-3 fatty acid lysine complex in terms of improved stability and bioavailability. It highlights how the unique complexation enhances the delivery and absorption of omega-3s, addressing common challenges associated with traditional omega-3 supplements.