Get Your Personalized Supplement StackSupplement Stack Quiz

Bacillus Indicus Hu36

Also known as: Bacillus indicus HU36, Bacillus HU36, Probiotene HU36

Overview

*Bacillus indicus* HU36 is a Gram-positive, spore-forming bacterium known for its probiotic properties and ability to produce carotenoids, pigments with antioxidant effects. It is isolated from human feces and used in dietary supplements and functional foods. A key characteristic is its ability to produce gastric-stable carotenoids, which are bioavailable after oral consumption. The bacterium can colonize the gut and remains stable in various food matrices without refrigeration, making it a convenient ingredient for diverse applications. Research suggests it stimulates the immune system, primarily through the activation of Toll-like receptors. However, the current evidence is primarily from in vitro and animal studies, with limited high-quality human clinical trials to fully validate its benefits and optimal usage.

Benefits

*Bacillus indicus* HU36 primarily offers immune stimulation through the activation of Toll-like receptors, specifically TLR2, leading to cytokine induction. This suggests a potential to modulate the gut-associated lymphoid tissue (GALT). Secondary benefits may include the exclusion of harmful pathogens and the production of beneficial nutrients within the gut. However, the evidence supporting these benefits is largely derived from in vitro and animal studies. Human studies are needed to quantify the effect sizes and clinical significance of these benefits. The time course of these benefits in humans is also not well-established, highlighting the need for further research to determine its efficacy in specific populations.

How it works

*Bacillus indicus* HU36 modulates the immune system by activating Toll-like receptors, particularly TLR2, which triggers the release of cytokines like TNFα. This interaction primarily occurs within the gut-associated lymphoid tissue (GALT), influencing the overall immune response. The carotenoids produced by *Bacillus indicus* HU36 are gastric-stable, enhancing their bioavailability and allowing them to exert antioxidant effects. The bacterium's ability to colonize the gut further supports its probiotic action, contributing to a balanced gut microbiota and improved immune function.

Side effects

Overall, *Bacillus indicus* HU36 is generally considered safe for oral use. However, there is a noted resistance to clindamycin, an antibiotic, which warrants further investigation to understand potential implications. Common, uncommon, and rare side effects are not well-documented in the available literature. Potential drug interactions, particularly with antibiotics like clindamycin, should be considered. Contraindications are not yet established. There is a lack of specific data available for vulnerable populations such as pregnant women, children, or immunocompromised individuals, emphasizing the need for caution and further research before recommending its use in these groups.

Dosage

The minimum effective dose, optimal dosage ranges, and maximum safe dose of *Bacillus indicus* HU36 are not yet established in human studies. Timing considerations for administration are also not specified. It is available in various food matrices and supplements, and its gastric stability enhances absorption. Due to the limited human data, specific dosage recommendations cannot be provided. Further research is needed to determine appropriate dosing guidelines and safety thresholds for different populations and health conditions.

FAQs

Is *Bacillus indicus* HU36 safe?

It's generally considered safe, but its resistance to clindamycin requires further study. Consult a healthcare provider before use, especially if you are taking antibiotics.

What are the benefits of taking *Bacillus indicus* HU36?

It may support immune function and provide antioxidant benefits due to its carotenoid production. However, more human studies are needed to confirm these effects.

How should I take *Bacillus indicus* HU36?

There are no specific guidelines on timing or administration. Follow the product label instructions or consult a healthcare provider for personalized advice.

Does *Bacillus indicus* HU36 need to be refrigerated?

No, it remains stable without refrigeration, making it convenient for use in various products. This is due to its spore-forming nature.

Research Sources

http://biospring.com.vn/wp-content/uploads/2015/06/COLORSPORE-Executive-Summary-05-05-FINAL.pdf – This executive summary highlights that *Bacillus indicus* HU36 produces gastric-stable carotenoids and can colonize the gut. It also notes the bacterium's stability in various food matrices without refrigeration, making it a versatile ingredient for functional foods and supplements.
https://pubmed.ncbi.nlm.nih.gov/18312567/ – This study focuses on the safety and colonization potential of *Bacillus indicus* HU36 using in vitro and in vivo models. The findings suggest that *Bacillus indicus* HU36 can stimulate the immune system and colonize the gut effectively, though the research is limited by the lack of human data.
http://sporegen.com/uploads/publications/Hong2008_160517_150904.pdf – This research assesses the safety of *Bacillus indicus* HU36 through acute and chronic dosing in animal models (guinea pigs and rabbits). The study found no toxicity associated with *Bacillus indicus* HU36, but it also noted the bacterium's resistance to clindamycin, an important consideration for potential drug interactions.
https://www.researchgate.net/publication/272475897_Use_of_Bacillus_indicus_HU36_as_a_Probiotic_Culture_in_Set-Type_Recombined_Non-Fat_Yoghurt_Production_and_Its_Effects_on_Quality – This study explores the use of *Bacillus indicus* HU36 as a probiotic culture in yogurt production and its effects on quality. The research indicates that incorporating *Bacillus indicus* HU36 can enhance the nutritional profile of yogurt, although the specific health benefits require further investigation.
https://www.lucymailing.com/the-complete-guide-to-soil-based-probiotics/ – This guide provides an overview of soil-based probiotics, including *Bacillus indicus* HU36, and their potential benefits for gut health. It emphasizes the importance of considering the specific strain and its documented effects when choosing a probiotic supplement.