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Bacillus Subtilis De111

Also known as: Bacillus subtilis DE111, B. subtilis DE111

Overview

*Bacillus subtilis* DE111 is a probiotic strain utilized to promote digestive and immune well-being. Naturally occurring in soil and the gastrointestinal tract, it is primarily used to enhance bowel regularity, alleviate gastrointestinal discomfort, and bolster immune defenses, particularly in athletes. A key feature is its resilience to acidic conditions and bile, enabling it to survive passage through the stomach and small intestine. Research on DE111 is moderately developed, with several studies available, but comprehensive systematic reviews and meta-analyses are somewhat limited. It is available in capsule form and is generally considered safe for consumption by healthy individuals. It works by increasing beneficial bacteria, inhibiting pathogen growth, and modulating immune responses through cytokine production.

Benefits

*Bacillus subtilis* DE111 has been shown to improve bowel movement patterns and reduce gastrointestinal symptoms such as diarrhea and constipation. Studies indicate that it can increase the population of beneficial bacteria like bifidobacteria in the gut. Research also suggests potential immune-boosting effects, including a reduction in inflammatory markers like TNF-α. Some studies have indicated that DE111 may help reduce body fat percentage in athletes. The benefits have been observed over periods ranging from 8 to 12 weeks in clinical trials. While specific effect sizes vary, statistically significant improvements in gastrointestinal health and immune markers have been reported.

How it works

*Bacillus subtilis* DE111 functions by augmenting the population of beneficial bacteria in the gut, inhibiting the proliferation of harmful pathogens, and modulating immune responses through the production of cytokines. It interacts primarily with the gastrointestinal tract and the immune system. As a probiotic, it colonizes the gut rather than being absorbed systemically. By promoting a balanced gut microbiota, DE111 supports digestive health and enhances immune function. This modulation helps to reduce inflammation and improve overall gastrointestinal well-being.

Side effects

*Bacillus subtilis* DE111 is generally considered safe for healthy individuals when taken orally. Common side effects are not well-documented, but probiotics are generally well-tolerated. Some individuals may experience mild gastrointestinal upset. In rare cases, individuals with weakened immune systems may be at risk of blood infections. No significant drug interactions have been reported, but caution is advised for those with compromised immune systems. The safety of DE111 in pregnancy, breastfeeding, and children is not well-established. It is recommended to consult with a healthcare provider before use, especially if you have underlying health conditions or are taking medications.

Dosage

The typical minimum effective dose of *Bacillus subtilis* DE111 is 1x10^9 CFU per day. While optimal dosage ranges are not definitively established, doses up to 5x10^9 CFU daily have been used in some studies. Although a maximum safe dose has not been established specifically for DE111, doses up to 10 billion CFU are generally considered safe for other *B. subtilis* strains. There are no specific timing recommendations for taking DE111. It is available in capsule form. As a probiotic that colonizes the gut, absorption factors are not applicable. No specific cofactors are required for its function.

FAQs

How should I store *Bacillus subtilis* DE111?

Store it properly to maintain its viability. Follow the storage instructions on the product label, typically in a cool, dry place.

When should I consult a healthcare provider?

Consult a healthcare provider if you have a weakened immune system or any underlying health conditions before taking this supplement.

When should I take *Bacillus subtilis* DE111?

There are no specific timing recommendations. You can take it at any time of day, with or without food, based on personal preference.

What results can I expect from taking this supplement?

You can expect improved gastrointestinal health and enhanced immune function with regular use, as supported by clinical studies.

Is *Bacillus subtilis* DE111 a substitute for medical treatment?

No, it is not a substitute for medical treatment. Consult a healthcare provider for specific health issues and do not rely solely on supplements.

Research Sources

https://e49e4bcf719d5ffce39c-f9fa0626754b99f92250fafa303db91e.ssl.cf3.rackcdn.com/Online%20Events/PB21/Deerland-DE111-whitepaper.pdf – This whitepaper summarizes several studies on *Bacillus subtilis* DE111, including a study showing increased normal stools in participants over 90 days and a study in female athletes showing reduced body fat percentage over 10 weeks. It also highlights a study in children attending daycare that showed a reduction in the duration of gastrointestinal symptoms with DE111 supplementation.
https://www.webmd.com/vitamins/ai/ingredientmono-1694/bacillus-subtilis – This WebMD article provides a general overview of *Bacillus subtilis*, noting its use as a probiotic and its potential benefits for digestive health. It also mentions precautions, such as the risk of blood infections in individuals with weakened immune systems, and advises caution during pregnancy and breastfeeding.
https://www.mdpi.com/2075-4663/6/3/70 – This study investigates the effects of *Bacillus subtilis* DE111 on the gut microbiota and immune function. The research suggests that DE111 can modulate the gut microbiota composition and enhance immune responses, contributing to improved gastrointestinal health.
https://www.researchgate.net/profile/Julen-Fernandez-Landa/publication/370118963_EFFECTS_OF_PROBIOTICS_ON_STRENGTH_AND_POWER_PERFORMANCE_IN_A_TRAINED_POPULATION_A_SYSTEMATIC_REVIEW_AND_META-ANALYSIS/links/644014ae2eca706c8b6d2f68/Effects-of-probiotics-on-strength-and-power-performance-in-a-trained-population-a-systematic-review-and-meta-analysis.pdf – This systematic review and meta-analysis examines the effects of probiotics on strength and power performance in trained individuals. While not specific to DE111, it provides context on the broader effects of probiotics on athletic performance and recovery, highlighting the potential for improved muscle function and reduced muscle damage.
https://onlinelibrary.wiley.com/doi/full/10.1002/jcsm.13132 – This study investigates the effects of probiotic supplementation on body composition and muscle strength in healthy adults. While not specific to DE111, it offers insights into the potential benefits of probiotics for improving body composition and muscle function, suggesting a possible role in enhancing overall physical performance.