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Bacillus Subtilis Hu58

Also known as: Bacillus subtilis HU58, B. subtilis HU58

Overview

*Bacillus subtilis* HU58 is a probiotic strain of the bacterium *Bacillus subtilis*, naturally found in soil and the human gastrointestinal tract. It's primarily used to support gut health and alleviate gastrointestinal disorder symptoms. A key characteristic is its spore-forming ability, enhancing stability and survival through the digestive system. Research indicates its effectiveness, especially when combined with *Bacillus coagulans* SC208, in managing antibiotic-associated diarrhea (AAD) and acute infectious diarrhea. It may also reduce abdominal pain, bloating, and flatulence. Available in capsule or syrup form, *B. subtilis* HU58 is generally considered safe for both children and adults, though consultation with a healthcare provider is advised for specific conditions or immunocompromised individuals. The research maturity level for *B. subtilis* HU58 is moderate, with several clinical trials but limited systematic reviews or meta-analyses available.

Benefits

*Bacillus subtilis* HU58, particularly in combination with *Bacillus coagulans* SC208, has shown benefits in managing gastrointestinal issues. Studies indicate significant improvements in stool frequency and consistency in patients with antibiotic-associated diarrhea (AAD). In children, this probiotic combination reduces the duration of acute infectious diarrhea and improves stool consistency. Secondary benefits include a reduction in abdominal pain, bloating, and flatulence. These benefits are typically observed within a week of supplementation. Clinical trials have demonstrated statistically significant improvements in gastrointestinal symptoms compared to placebo. While generally safe, individual results may vary, and consultation with a healthcare provider is recommended for personalized advice.

How it works

*Bacillus subtilis* HU58 primarily modulates the gut microbiota, enhancing the intestinal epithelium's barrier function and potentially influencing immune responses. As a spore-forming probiotic, it exhibits high resistance to stomach acid, ensuring survival through the digestive tract. While specific molecular targets are not well-defined, the probiotic likely interacts with cytokines and other immune mediators. Its interaction with the gastrointestinal system may also influence systemic immune responses. The exact mechanisms are still under investigation, but the probiotic's ability to balance gut flora and support intestinal health is evident from clinical studies.

Side effects

*Bacillus subtilis* HU58 is generally considered safe, with no significant adverse effects reported in clinical trials. Common side effects are rare, but mild gastrointestinal symptoms may occur in some individuals. No serious adverse events have been directly associated with *B. subtilis* HU58. While no significant drug interactions have been reported, caution is advised when taken with immunosuppressive drugs. It is generally not recommended for severely immunocompromised individuals. Pregnant or breastfeeding women should consult healthcare providers before use. Overall, the safety profile of *B. subtilis* HU58 is favorable, but monitoring for any adverse reactions is always recommended.

Dosage

The typical effective dose of *Bacillus subtilis* HU58 is around 3 x 10^9 CFU per capsule, often administered in combination with other probiotics. The optimal dosage range is generally between 1 x 10^9 and 3 x 10^9 CFU per day. While no maximum safe dose has been definitively established, higher doses are not commonly used. It is best taken with meals to enhance survival through the stomach. Available in capsule or syrup forms, the spore form enhances survival through the digestive system. No specific cofactors are required for its effectiveness. Consult a healthcare provider for personalized dosage recommendations.

FAQs

How should I store *Bacillus subtilis* HU58?

Store it properly to maintain viability, typically in a cool, dry place away from direct sunlight. Follow the storage instructions on the product label.

Is *Bacillus subtilis* HU58 safe for everyone?

It is generally safe, but if you are immunocompromised, consult a healthcare provider before use to ensure it is appropriate for your condition.

When is the best time to take *Bacillus subtilis* HU58?

It is best taken with meals to enhance its survival through the stomach and improve its effectiveness in the gut.

How long before I see results from taking *Bacillus subtilis* HU58?

You may observe improvements in gastrointestinal symptoms within a week of consistent supplementation, but individual results can vary.

Can *Bacillus subtilis* HU58 cure all gastrointestinal issues?

No, it is not a cure-all. Consult a healthcare provider for specific conditions and appropriate treatment plans. It is a supplement to support gut health.

Research Sources

https://biomedres.us/fulltexts/BJSTR.MS.ID.004839.php – This open-labeled, placebo-controlled trial with 75 patients found that a combination of *B. subtilis* HU58 and *B. coagulans* SC208 significantly improved stool frequency and consistency compared to placebo in adults with antibiotic-associated diarrhea (AAD). The study lasted for 7 days and suggests the probiotic combination is effective for managing AAD symptoms, though the open-label design calls for further blinded studies to confirm these findings.
https://pubmed.ncbi.nlm.nih.gov/32714397/ – This study investigated the effects of *Bacillus subtilis* on intestinal microbiota and metabolites in mice. It found that *Bacillus subtilis* supplementation can modulate the gut microbiota composition and metabolic activity, potentially leading to improved gut health. The research provides insights into the mechanisms by which *Bacillus subtilis* may exert its probiotic effects.
https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1370 – This double-blind, randomized, placebo-controlled trial involving 64 children demonstrated that a combination of *B. subtilis* HU58 and *B. coagulans* SC208 significantly improved stool consistency and reduced the duration of diarrhea in children with acute diarrhea. The study highlights the effectiveness of this probiotic combination in managing acute infectious diarrhea in the pediatric population.
https://pubmed.ncbi.nlm.nih.gov/32664604/ – This study examined the impact of *Bacillus subtilis* on gut health and immune response. The findings suggest that *Bacillus subtilis* can enhance gut barrier function and modulate immune responses, contributing to overall gut health. The research provides a deeper understanding of the probiotic's mechanisms of action.
https://www.researchgate.net/publication/342581909_An_Oral_Formulation_of_the_Probiotic_Bacillus_subtilis_HU58_Was_Safe_and_Well_Tolerated_in_a_Pilot_Study_of_Patients_with_Hepatic_Encephalopathy – This double-blind, placebo-controlled pilot study with 40 patients found that *B. subtilis* HU58 was safe and well-tolerated, with a trend toward reducing blood ammonia levels in patients with high baseline levels of hepatic encephalopathy. The study suggests potential benefits for managing hepatic encephalopathy, but the small sample size limits the generalizability of the findings.