Resveratrol (from Organic Beet Root Extract)
Also known as: Resveratrol, trans-resveratrol, stilbenoid, 3,5,4'-trihydroxy-trans-stilbene, Organic Beet Root Extract, Beta vulgaris L., beetroot, beet juice extract
Overview
Resveratrol is a polyphenol found in grapes, berries, peanuts, and Japanese knotweed, known for its antioxidant and anti-inflammatory properties. It's often used for cardiovascular and metabolic health. Organic Beet Root Extract, derived from Beta vulgaris, is rich in nitrates and betalains, supporting cardiovascular health, exercise performance, and blood pressure management. Resveratrol's bioavailability is low due to rapid metabolism, while Beet Root Extract promotes nitric oxide production. Research on Resveratrol is moderate to high, with numerous RCTs and meta-analyses, while Beet Root Extract has moderate research support with several RCTs and systematic reviews. Both are considered to have good evidence for their respective benefits, though results can vary.
Benefits
Resveratrol has shown significant reductions in waist circumference, hemoglobin A1c, total cholesterol, and LDL, along with a modest increase in HDL, particularly in individuals with metabolic syndrome and type 2 diabetes. Beet Root Extract has demonstrated improved vagal modulation and heart rate recovery post-exercise in CAD patients. Resveratrol may also have anti-inflammatory and antioxidant effects, though clinical significance is less clear. Beet Root Extract may lower blood pressure and improve exercise tolerance, with most evidence in cardiovascular disease and athletic populations. The effect sizes for Resveratrol are small to moderate for metabolic parameters, while Beet Root Extract shows modest improvements in cardiovascular recovery. Resveratrol benefits are typically observed with chronic supplementation, while Beet Root Extract can have acute effects on cardiovascular recovery.
How it works
Resveratrol primarily works by activating SIRT1, AMPK, and Nrf2 pathways, which modulate inflammation and oxidative stress. These pathways influence cellular energy balance, antioxidant defense, and overall metabolic function. Beet Root Extract increases nitric oxide levels via the nitrate-nitrite-NO pathway, improving endothelial function and vasodilation. Resveratrol interacts with cardiovascular, metabolic, and potentially neurological systems, while Beet Root Extract primarily affects the cardiovascular and muscular systems. Molecular targets for Resveratrol include SIRT1, AMPK, Nrf2, and NF-κB, while Beet Root Extract targets nitric oxide synthase and endothelial cells.
Side effects
Resveratrol is generally safe at typical doses, with mild gastrointestinal discomfort being the most common side effect. Uncommon side effects include headache and fatigue, while rare side effects may include allergic reactions and liver enzyme elevation. It may interact with anticoagulants, antiplatelet drugs, and CYP3A4 substrates. Resveratrol is contraindicated in pregnancy and breastfeeding due to insufficient data. Beet Root Extract is also generally safe, with mild gastrointestinal discomfort and red urine/feces being common. Uncommon side effects include headache and hypotension, while rare side effects may include allergic reactions and a theoretical risk of kidney stones. It may potentiate the effects of antihypertensives. Beet Root Extract should be used with caution in individuals with severe hypotension or a history of kidney stones.
Dosage
For Resveratrol, a minimum effective dose is 100–150 mg/day for metabolic effects, with optimal dosage ranges between 150–500 mg/day. Up to 1000 mg/day has been used in clinical trials, but higher doses are not well studied. It is best taken with meals to improve absorption. Micronized forms or co-administration with piperine can also enhance absorption. For Beet Root Extract, a minimum effective dose is 300–500 mg/day (or equivalent nitrate dose), with optimal dosage ranges between 500–1000 mg/day (or equivalent nitrate dose). Up to 2000 mg/day (or equivalent nitrate dose) has been used in clinical trials. It is recommended to take it 1–3 hours before exercise or as directed. Standardized forms for nitrate content are preferred, and absorption can be enhanced by a low-nitrate diet prior to supplementation.
FAQs
When is the best time to take Resveratrol?
Resveratrol is best taken with food to enhance absorption. The effects may take several weeks to manifest, so consistent daily use is recommended.
When is the best time to take Beet Root Extract?
Beet Root Extract is best taken 1-3 hours before exercise for performance benefits or daily for blood pressure management. Monitor blood pressure if you are also taking antihypertensive medications.
Is Resveratrol safe to take with other medications?
Resveratrol may interact with anticoagulants, antiplatelet drugs, and CYP3A4 substrates. Consult with a healthcare provider to monitor for potential drug interactions.
Is Beet Root Extract safe for people with low blood pressure?
Beet Root Extract can lower blood pressure, so it should be used with caution in individuals with hypotension. Monitor blood pressure regularly.
What are the expected results from taking Resveratrol?
Resveratrol may lead to modest improvements in metabolic health over several weeks, including reductions in waist circumference, HbA1c, and cholesterol levels.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/39853480/ – This randomized controlled trial (n=14 males with CAD) investigated the acute effects of beetroot extract and resveratrol on cardiac autonomic modulation after exercise. The study found that both beetroot extract and resveratrol enhanced vagal modulation and heart rate recovery compared to rest, suggesting potential benefits for cardiovascular recovery in individuals with coronary artery disease.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9332300/ – This systematic review and meta-analysis examined the effect of herbal supplements, including resveratrol and beetroot juice, on blood pressure. The review concluded that these supplements modestly lower blood pressure, although the effect sizes are generally small to moderate, indicating a potential role in blood pressure management.
- https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.795980/full – This systematic review and meta-analysis (1,171 participants across 25 studies) assessed the efficacy of resveratrol supplementation on glucose and lipid metabolism. The study found that resveratrol significantly reduced waist circumference, HbA1c, total cholesterol, and LDL, while modestly increasing HDL, suggesting benefits for metabolic health.
- https://www.webmd.com/vitamins/ai/ingredientmono-307/resveratrol – WebMD provides general information about resveratrol, including its uses, potential benefits, side effects, and interactions. It serves as a broad overview of the supplement, but lacks the depth of peer-reviewed research.
- https://www.mdpi.com/2673-396X/5/2/16 – This is a review article discussing the potential health benefits of resveratrol. It covers various aspects such as its antioxidant properties, cardiovascular effects, and anti-inflammatory actions, providing a comprehensive overview of resveratrol's potential therapeutic applications.
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