Bergamonte Full Spectrum Bergamot Extract
Also known as: Bergamot, Bergamonte, *Citrus bergamia* Risso
Overview
Bergamot is a citrus fruit native to Southern Italy, specifically the Calabria region. The extract, derived from the juice and albedo of the fruit, is rich in polyphenolic flavonoids such as naringin and neohesperidin. It is primarily utilized for its potential benefits in managing cholesterol levels, enhancing glucose metabolism, and reducing inflammation. With a growing body of clinical research, including randomized controlled trials and systematic reviews, the efficacy of bergamot extract in promoting metabolic and vascular health is well-documented. The extract is typically standardized to ensure consistent levels of its bioactive components, contributing to its functional applications in nutraceuticals.
Benefits
Bergamot extract has demonstrated several evidence-based benefits, particularly in the realm of metabolic health. Significant reductions in total cholesterol (12.3% to 31.3%), LDL cholesterol (7.6% to 40.8%), and triglycerides (11.5% to 39.5%) have been observed. Improvements in insulin sensitivity, reflected by a 12.2% reduction in HOMA-IR scores, highlight its effect on glucose metabolism. Additionally, it is noted for reducing inflammation, as evidenced by a 17.9% decrease in high-sensitivity C-reactive protein levels. Certain populations, such as individuals with metabolic syndrome or those intolerant to statins, may experience the most pronounced benefits, and some evidence suggests weight management improvements as well.
How it works
Bergamot extract functions through multiple mechanisms due to its rich array of polyphenolic components. Key compounds like neohesperidin inhibit the enzyme responsible for cholesterol production, while others, such as brutieridin, inhibit cholesterol absorption in the intestines. It also enhances insulin sensitivity and reduces inflammation through the synergistic effects of its bioactive constituents, affecting various metabolic and cardiovascular pathways.
Side effects
Generally deemed safe, bergamot extract can cause certain side effects, with increased photosensitivity noted in over 5% of users due to its photosensitizing properties. Allergic reactions, such as rashes or difficulty breathing, occur in 1-5% of users, while rare effects (<1%) are less documented. Drug interactions should be approached with caution, especially with photosensitizers and certain medications for diabetes or statins, as they may enhance side effects. Pregnant or nursing individuals, children, and those with sun sensitivity should avoid implementation without professional advice, and consultation with a healthcare provider is recommended for those on concurrent medications.
Dosage
The clinically studied dosage of bergamot extract typically ranges from 150 mg to 500 mg per day. While a definitive minimum effective dose is not firmly established, these amounts seem to yield beneficial health impacts regarding cholesterol and glucose metabolism. Administration timing does not appear explicitly defined but should align with usage found in clinical trials. The extract is available in various forms, including capsules or powders, each with differing bioavailability influenced by formulation. No maximum safe dose is established, but higher doses should be approached with caution due to insufficient studies.
FAQs
Is bergamot extract safe for everyone?
Bergamot extract is generally safe, but it is advised to consult a healthcare provider, especially for individuals with existing health conditions or those taking medications.
How long does it take to see results from bergamot supplementation?
Users can typically expect to see improvements in cholesterol levels and inflammation markers after several weeks to a few months of consistent use.
Can bergamot be used as a replacement for medications?
No, bergamot should not replace prescribed medications but may serve as a complementary approach under medical supervision.
What is the best time to take bergamot extract?
While literature does not specify timing, it is advisable to follow the dosing schedule used in clinical trials, typically once daily.
Research Sources
- https://cris.unibo.it/retrieve/4ab3c21e-31d6-43cc-809e-6d58dd9f5c11/Fogacci%20F_Metabolic%20and%20vascular%20effect_Arch%20Med%20Sci.pdf – A randomized, double-blind, placebo-controlled trial involving 120 participants examined the metabolic and vascular effects of bergamot extract over 12 weeks, finding significant improvements in cholesterol and inflammatory markers compared to placebo.
- https://www.mdpi.com/2304-8158/13/23/3883 – This systematic review includes 12 studies with over 500 participants, highlighting significant decreases in total cholesterol, LDL cholesterol, and triglycerides, emphasizing dose-dependent effects and interactions with statins.
- https://pubmed.ncbi.nlm.nih.gov/31670973/ – This study focused on the hypoglycemic and hypolipemic effects of bergamot on 80 individuals with dyslipidemia over 12 weeks, revealing notable improvements in lipid profiles and glucose metabolism.
- https://bergamonte.net – Bergamonte's site provides insights into the health benefits of bergamot extract, with claims supported by several clinical studies indicating its effectiveness in managing cholesterol levels and improving metabolic health.
- https://www.healthline.com/health/cholesterol/can-bergamot-lower-cholesterol – This article discusses bergamot's role in lowering cholesterol and highlights scientific research supporting its efficacy, emphasizing its use as a complementary treatment for lipid management.