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Bhumi Amla

Also known as: Phyllanthus niruri, Phyllanthus amarus, Bhumi Amla, Bhui Amla, Stonebreaker, Chanca Piedra

Overview

Bhumi Amla, primarily referring to *Phyllanthus niruri* and related species like *Phyllanthus amarus*, is a perennial herb traditionally used in Ayurvedic and Unani medicine. It belongs to the Euphorbiaceae family and is characterized by its small size and widespread use in traditional medicine systems. Historically, it has been used for liver disorders such as jaundice and hepatitis B, as well as for diabetes, chronic fever, and gastrointestinal ailments. The plant contains various chemical compounds, including phyllanthin, hypophyllanthin, lignans, flavonoids, and alkaloids, which are believed to contribute to its therapeutic effects. Current research is primarily preclinical and observational, with limited high-quality clinical trials to support its traditional uses. The evidence quality is generally low to moderate, relying heavily on in vitro and animal studies.

Benefits

Bhumi Amla is purported to have several health benefits, primarily related to liver health. Anecdotal and preclinical data suggest it may have hepatoprotective effects, potentially normalizing liver enzymes and exhibiting antiviral activity against hepatitis B. However, human trials are lacking to confirm these effects. Limited evidence suggests potential antidiabetic properties, with some mechanistic similarities noted to *Emblica officinalis*, although direct randomized controlled trials (RCTs) are absent. Computational studies have also proposed potential antiviral activity against SARS-CoV-2, but these findings are purely hypothetical and lack in vivo validation. Overall, the evidence supporting the benefits of Bhumi Amla is preliminary and requires further rigorous clinical investigation.

How it works

The mechanism of action of Bhumi Amla is not fully understood but is believed to involve several pathways. For hepatitis B, it is thought to inhibit HBV DNA polymerase. The presence of lignans, such as phyllanthin, contributes to its antioxidant activity. Some research suggests it may modulate the ACE2 receptor, which is relevant to COVID-19, although this remains a hypothesis. The bioavailability of Bhumi Amla's active compounds is poorly characterized, but it is likely low due to the high polyphenol content. Further research is needed to fully elucidate its mechanisms of action and bioavailability.

Side effects

Common side effects of Bhumi Amla include mild gastrointestinal distress, which appears to be dose-dependent. There is a theoretical risk of drug interactions with anticoagulants due to potential antiplatelet effects. It is contraindicated in pregnancy due to reports of uterine stimulant effects in traditional use. Caution is advised in individuals with hepatic impairment, as there is a lack of safety data for this population. Comprehensive safety data, especially from well-designed clinical trials, is needed to fully characterize the side effect profile of Bhumi Amla.

Dosage

Traditional use of Bhumi Amla involves dosages of 500–2,000 mg of the dried herb daily, although standardization is lacking. Due to the limited number of clinical trials, there are no established recommended dosages based on robust clinical evidence. Aqueous extracts are sometimes preferred for liver conditions, but specific dosage recommendations for different forms are not well-defined. It's important to note that without standardized extracts and clinical trials, determining a safe and effective dosage is challenging. Upper limits and safety thresholds are not clearly established, emphasizing the need for caution when using Bhumi Amla as a supplement.

FAQs

Is Bhumi Amla effective for treating hepatitis B?

Preclinical evidence suggests potential antiviral activity, but no human trials have confirmed clinical benefits. More research is needed.

Can Bhumi Amla be used to treat COVID-19?

Computational studies suggest potential antiviral effects, but no in vivo studies have demonstrated efficacy. Its use for COVID-19 is purely speculative.

Does Bhumi Amla protect the liver?

Anecdotal reports suggest liver protection, but there is insufficient evidence for therapeutic claims. Further clinical trials are necessary.

Are there any safety concerns with Bhumi Amla?

Mild gastrointestinal distress is common. It's contraindicated in pregnancy and caution is advised with anticoagulants and in hepatic impairment.

Research Sources

  • https://www.ijnrd.org/papers/IJNRD2211142.pdf – This review article compiles traditional uses of Bhumi Amla and explores in vitro hepatoprotective mechanisms. It highlights the historical context and potential biological activities but lacks clinical data and relies on historical texts, limiting its applicability to modern clinical practice.
  • https://pmc.ncbi.nlm.nih.gov/articles/PMC8302490/ – This in silico docking analysis suggests that phyllanthin, a compound found in Bhumi Amla, exhibits binding affinity to the SARS-CoV-2 Mpro protease. However, the study lacks experimental validation, and the clinical relevance of these findings remains unknown, making it a preliminary investigation.
  • https://www.arcjournals.org/pdfs/ijarcs/v5-i2/1.pdf – This phytochemical characterization study identifies lignans and amino acids as primary constituents of Bhumi Amla. While it provides insights into the plant's chemical composition, it lacks clinical correlation and the methodology is not clearly defined, reducing its overall impact.
  • https://pubmed.ncbi.nlm.nih.gov/36934568/ – This study investigates the effects of Phyllanthus niruri on non-alcoholic fatty liver disease (NAFLD) in rats. The results suggest that Phyllanthus niruri may have a protective effect on the liver by reducing inflammation and oxidative stress, indicating its potential as a therapeutic agent for NAFLD.
  • https://www.binasss.sa.cr/mar23/27.pdf – This document discusses the traditional uses and chemical composition of Phyllanthus niruri, highlighting its potential medicinal properties. It emphasizes the need for further research to validate these traditional uses and to fully understand the plant's pharmacological effects.

Supplements Containing Bhumi Amla

LIVER DETOX by AURIC
55

LIVER DETOX

AURIC

Score: 55/100
LIVER FORTE by HEALEO® NUTRITION
83

LIVER FORTE

HEALEO® NUTRITION

Score: 83/100