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Bifidobacteria Bifidum

Also known as: *B. bifidum*, Bifidobacteria, *Bifidobacterium bifidum*

Overview

*Bifidobacterium bifidum* is a species of probiotic bacteria naturally found in the human gut, especially prevalent in breast milk and fecal samples of infants. This bacteria is renowned for its abilities to ferment lactose and various sugars, playing a vital role in gut health. It is primarily utilized to improve gut flora balance, prevent various infections, and potentially mitigate atopic diseases. The existing research on *B. bifidum* indicates a moderate maturity level, with numerous randomized controlled trials (RCTs) supporting its therapeutic benefits in infants and adults alike. Notably, it demonstrates good quality evidence advocating for its benefits, particularly for maintaining gut eubiosis and enhancing immune responses.

Benefits

*Bifidobacterium bifidum* has several evidenced-based benefits, particularly in atopic disease prevention, where studies indicate it significantly reduces the incidence of conditions like atopic dermatitis and respiratory infections in cesarean-born children. Additionally, it promotes gut health by enhancing the biodiversity of intestinal microbiota. Especially relevant for preterm infants, *B. bifidum* has shown efficacy in minimizing risks associated with necrotizing enterocolitis (NEC) and late-onset sepsis (LOS). Evidence suggests that the relative risk for NEC is reduced significantly in infants receiving probiotics. These findings are underlined by high-quality studies and systematic reviews, establishing *B. bifidum* as a beneficial supplement primarily for gut health and immune support in infants and young children.

How it works

*Bifidobacterium bifidum* functions by modulating the gut microbiota, thus enhancing the integrity of intestinal barriers and promoting immune system activity. It primarily interacts with the gastrointestinal and immune systems. Probiotics like *B. bifidum* influence cytokine production and support gut barrier function, though specific molecular targets for this species are not fully known. Notably, it does not get absorbed into the systemic circulation but rather colonizes the gut, where it exerts its beneficial effects.

Side effects

The safety profile of *Bifidobacterium bifidum* is generally favorable; common side effects include mild gastrointestinal discomfort such as bloating or gas, affecting more than 5% of users. Serious adverse effects are rare, with potential for systemic infections in severely immunocompromised persons being an exception. Moreover, no significant drug interactions have been identified, nor are there widespread contraindications, apart from noted caution for severely immunocompromised individuals. Therefore, it is deemed safe, including for usage in infants, provided no specific immune issues are present.

Dosage

Optimal dosages of *Bifidobacterium bifidum* usually range from 10^9 to 10^10 colony-forming units (CFU) per serving, although a minimum effective dose has not been well defined. It can be administered at any time of day, most effectively taken with food to minimize gastrointestinal upset. Forms include capsules, powders, and specialized infant formulas, with no known absorption concerns since it acts by colonizing the gut. The maximum safe dose has not been formally established, but typical dosages are generally regarded as safe.

FAQs

How should I store *B. bifidum*?

Store *Bifidobacterium bifidum* in a cool, dry place to maintain its viability as a probiotic.

Can infants take *B. bifidum*?

Yes, *B. bifidum* is safe for infants, including preterm infants, for gut health support.

When is the best time to take *B. bifidum*?

It can be taken at any time, ideally with meals to help minimize gastrointestinal discomfort.

What results can I expect from taking *B. bifidum*?

Users generally experience improved gut health and potentially lower risk of atopic diseases, especially in infants.

Is *B. bifidum* a cure for diseases?

No, *Bifidobacterium bifidum* is not a cure but supports overall health and gut well-being.

Research Sources

https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1463848/full – This study highlights the effectiveness of probiotics in managing depressive symptoms and improving gut health, with promising implications for various strains including *Bifidobacterium* species.
https://pubmed.ncbi.nlm.nih.gov/38930475/ – Demonstrates that probiotics, including *Bifidobacterium bifidum*, can prevent atopic conditions in infants, showcasing a significant reduction in associated infections.
https://pubmed.ncbi.nlm.nih.gov/37460707/ – A systematic review that underscores the efficacy of probiotics in reducing the incidence of necrotizing enterocolitis (NEC) in preterm infants, indirectly supporting the use of *B. bifidum*.