Bifidobacteria Breve
Also known as: Bifidobacterium breve, B. breve
Overview
*Bifidobacterium breve* is a species of probiotic bacteria that is naturally present in the human gut and breast milk. It is crucial for maintaining gut health and supporting immune function. B. breve is primarily used to enhance gut health, combat infections, and bolster immune responses, especially in infants and individuals with compromised gut microbiota. This bacterium is distinguished by its ability to colonize the gut early in life, facilitating the development of a balanced gut microbiome. Research on B. breve is ongoing, with a moderate maturity level indicating promising potential but necessitating more rigorous studies to establish long-term efficacy. The evidence base varies, with some studies yielding supportive results.
Benefits
Research indicates that *B. breve* offers several evidence-backed benefits. In preterm infants, a systematic review identified its potential to reduce late-onset sepsis and mortality, although the evidence quality is considered very low. Early administration of *B. breve* also promotes bifidobacterial colonization while reducing Enterobacteriaceae in low birth weight infants. Secondary effects of *B. breve* suggest it may enhance cognitive function in neurodegenerative models and improve lifestyle behaviors, such as sleep quality, in healthy adults. Most significantly, the benefits have been observed primarily in vulnerable populations like preterm and low birth weight infants. Effect sizes vary, with notable reductions in sepsis observed in some studies, suggesting potential clinical significance.
How it works
*Bifidobacterium breve* functions by colonizing the gut, enhancing gut barrier integrity, and modulating immune responses. It interacts with various body systems, particularly the gut-brain axis, influencing neurotransmitter levels that may affect cognitive processes. While specific molecular targets remain largely undefined, its effects likely involve the gut-associated lymphoid tissue (GALT) and short-chain fatty acid production, contributing to improved gut health.
Side effects
Generally, *Bifidobacterium breve* is regarded as safe, with clinical studies reporting no significant adverse effects. There have been no common side effects reported (>5%) or uncommon side effects documented (1-5%). Likewise, rare side effects (<1%) have not been identified. No substantial drug interactions have been noted, and there are no established contraindications. It is considered safe for use in special populations, including preterm infants. Nonetheless, as with any probiotic, it is prudent to consult a healthcare provider for use in individuals with compromised immune systems or other health concerns.
Dosage
For effective dosing, *B. breve* is generally administered in amounts ranging from 10^8 to 10^9 CFU per day, with commonly used doses around 10^9 CFU. Although the maximum safe dose is not specifically defined, high doses are typically well tolerated. Optimal timing for administration is crucial, particularly in infants for maximizing gut colonization benefits. *B. breve* can be found in various forms such as capsules and powders, and as it primarily colonizes the gut, absorption factors are not applicable. No co-factors are required for its effectiveness.
FAQs
What is the best way to store *Bifidobacterium breve* supplements?
Store in a cool, dry place, and follow the manufacturer's instructions to ensure probiotics remain viable.
Is *B. breve* safe for all ages?
Yes, *B. breve* is considered safe for use in infants, including preterm newborns; however, consult a healthcare provider for vulnerable populations.
When is the best time to take *B. breve*?
Early administration, especially in infants, is recommended to promote optimal gut colonization.
What health benefits can I expect from using *Bifidobacterium breve*?
You might experience improved gut health and potential reductions in infections, particularly if you're in a vulnerable population.
Can *B. breve* cure gut issues?
*B. breve* is not a cure-all for digestive issues; individual responses can vary significantly.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/28796951/ – This systematic review assessed *B. breve M-16V* in preterm infants, reporting limited benefit in RCTs for sepsis and mortality reduction, while non-RCT outcomes suggested potential advantages.
- https://pubmed.ncbi.nlm.nih.gov/15491374/ – A controlled trial demonstrated that the early administration of *B. breve* significantly promotes bifidobacterial colonization in low birth weight infants.
- https://www.mdpi.com/2072-6643/17/3/391 – Research indicated that *B. breve* may have cognitive benefits, particularly in models of neurodegenerative diseases, suggesting a potential for cognitive enhancement.
- https://pubmed.ncbi.nlm.nih.gov/38869657/ – *B. breve 207-1* was shown to enhance sleep quality and positively influence lifestyle behaviors in healthy adults, indicating its broader benefits beyond gut health.
- https://www.mdpi.com/2072-6643/11/8/1724 – This study explored various health benefits attributed to *B. breve*, highlighting its role in gut health, immunity, and overall well-being.
Supplements Containing Bifidobacteria Breve
Colon Support Probiotic 20 Billion CFU
Probulin
Probulin 6 Billion CFU
Probulin
Daily Care Probiotic 10 Billion
Greens First Pro
Digestive 5.0 Full-Spectrum Hemp Extract
Hemp Fusion
Y Skin Postbiotic Food Supplement
Nourishme Organics / The Y Collection
