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Bifidobacterium Bifidum Extract

Also known as: Bifidobacterium bifidum extract, B. bifidum, Bifidobacterium bifidum

Overview

*Bifidobacterium bifidum* is a beneficial bacterium that resides predominantly in the human gut, especially in breastfed infants, and is recognized for its probiotic properties. Its primary applications include the promotion of gut health and potential therapeutic effects on conditions such as irritable bowel syndrome (IBS) and depression. One of its notable characteristics is its ability to produce exopolysaccharides, which may aid in carbohydrate metabolism within the gut. The research surrounding *B. bifidum* encompasses a range of studies, with a moderate level of maturity in the evidence base. Systematic reviews and high-quality meta-analyses have documented its health benefits, but the quality of evidence varies across studies.

Benefits

The evidence-based benefits of *Bifidobacterium bifidum* are multifaceted. Primarily, it has shown effectiveness in reducing depression scale scores in individuals with depressive symptoms, particularly when combined with conventional antidepressant treatments. Additionally, it demonstrates protective effects against necrotizing enterocolitis in preterm infants. While targeted studies on IBS and *B. bifidum* are limited, probiotics in general have been associated with alleviating symptoms of IBS. The specific populations that benefit most include preterm infants and individuals experiencing various forms of depression. Effect sizes for depression suggest moderate efficacy, continuing to highlight the relevance of *B. bifidum* in these health contexts.

How it works

The mechanism of action of *Bifidobacterium bifidum* primarily involves its influence on gut microbiota composition, which contributes to the modulation of the gut-brain axis, thus impacting mental health and metabolic functions. It interacts with the gastrointestinal system and may send signals to the central nervous system through this axis. Although specific molecular targets for *B. bifidum* are not fully elucidated, it is understood that it may modulate inflammatory pathways and neurotransmitter production, thereby contributing to its beneficial effects.

Side effects

The safety profile of *Bifidobacterium bifidum* is generally positive, with most users experiencing no adverse reactions. Common side effects are mild gastrointestinal symtoms such as bloating and gas. Uncommon or rare side effects are not significantly reported, although there is a potential infection risk in immunocompromised individuals, notably in those with weakened immune systems. Therefore, it is advised that individuals in this category consult with healthcare professionals before starting supplementation. No significant drug interactions have been noted, making it a safe choice for the general population; however, caution is warranted for individuals with specific health conditions.

Dosage

Currently, there is no well-established minimum effective dosage for *Bifidobacterium bifidum* as it is commonly included in probiotic blends. Optimal dosage typically varies among products, with many containing a range of 1-10 billion CFU (colony-forming units) per serving. While an upper limit has not been concretely established, it is widely recognized that *Bifidobacterium bifidum* is safe within typical dosages found in probiotic supplements. For best results, intake should occur with food to enhance its survival through the digestive system. Typical forms include capsules and powders, and ensuring product viability is important for effective supplementation.

FAQs

How should I store *Bifidobacterium bifidum* supplements?

Store supplements in a cool, dry place to ensure their viability and effectiveness.

Is *Bifidobacterium bifidum* safe for everyone?

Generally safe for most, but immunocompromised individuals should consult a healthcare provider.

When is the best time to take *Bifidobacterium bifidum*?

It is best to take it with meals to improve its survival through the stomach.

How long before I can expect to see benefits?

It may take several weeks to experience noticeable benefits from supplementation.

Is *Bifidobacterium bifidum* a cure for gut problems?

No, it is not a cure-all; it should be part of a comprehensive health strategy.

Research Sources

https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1463848/full – This meta-analysis of 13 randomized controlled trials shows that Bifidobacterium-related preparations significantly reduce depression scale scores, highlighting the potential of probiotics in mental health treatment despite some study heterogeneity.
https://pubmed.ncbi.nlm.nih.gov/30500473/ – This systematic review and meta-analysis of 24 RCTs demonstrates that Bifidobacterium significantly reduces the risk of necrotizing enterocolitis in preterm infants, indicating its protective role in neonatal gut health.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6927028/ – A systematic review of 72 RCTs suggests that probiotics, including those from Bifidobacterium, may alleviate symptoms of IBS, although results vary due to differences in probiotic strains used.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10453370/ – This systematic review discusses the general effects of probiotics on gut health, emphasizing the importance of considering specific strains like *Bifidobacterium bifidum* for targeted health benefits.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10651259/ – This analysis provides insights into the holistic effects of probiotics on mental health, reinforcing the link between gut microbiota and psychological wellness, particularly in depressive disorders.