Bifidobacterium bifidum PXN 23
Also known as: Bifidobacterium bifidum PXN 23, Bifidobacterium bifidum strain PXN 23, Bifidobacterium bifidum
Overview
Bifidobacterium bifidum PXN 23 is a specific probiotic strain belonging to the Bifidobacterium genus, naturally residing in the human gut, particularly the colon. It is recognized for its role in maintaining gut health and modulating immune responses. This strain is primarily utilized in probiotic supplements to enhance gastrointestinal function, alleviate symptoms associated with irritable bowel syndrome (IBS), and address constipation. It may also play a role in modulating neurological symptoms linked to gut-brain axis disorders. Key characteristics include its resilience to gastrointestinal transit, ability to adhere to intestinal mucosa, and beneficial impact on the gut microbial balance. While research on B. bifidum PXN 23 is ongoing, it is frequently studied as a component of multi-strain probiotic formulations, which can limit isolated evidence. The current body of evidence is moderate, with some systematic reviews and randomized controlled trials (RCTs) incorporating this strain within broader probiotic mixtures.
Benefits
Probiotic formulations containing Bifidobacterium bifidum PXN 23 have shown efficacy in improving symptoms of Irritable Bowel Syndrome (IBS), including abdominal pain and bloating. Meta-analyses of probiotics for IBS have reported statistically significant symptom relief compared to placebo. In neurological contexts, such as multiple sclerosis (MS) and Parkinson’s disease-related constipation, multi-strain probiotics that include B. bifidum PXN 23 have demonstrated improvements in gastrointestinal symptoms and some neurodegenerative disease-related outcomes. Secondary benefits may include general improvements in quality of life related to gastrointestinal health. While some meta-analyses suggest potential adjunctive benefits in neuropsychiatric disorders like ADHD, the specific contribution of B. bifidum PXN 23 in these studies is not isolated. Adults with IBS and neurodegenerative diseases appear to benefit most from formulations containing this strain. Benefits are typically observed after 4 to 24 weeks of consistent supplementation.
How it works
Bifidobacterium bifidum PXN 23 exerts its beneficial effects primarily by modulating the gut microbiota composition, promoting the growth of beneficial bacteria while potentially suppressing pathogenic microorganisms. It contributes to gut health by producing short-chain fatty acids (SCFAs), which are crucial for maintaining gut barrier integrity and reducing inflammation. This strain also interacts with the host immune system, helping to mitigate gut inflammation and modulate broader systemic immune responses. Furthermore, B. bifidum PXN 23 may influence the gut-brain axis through microbial metabolites, potentially impacting neurological function. As a live bacterial strain, its efficacy depends on its ability to survive the acidic environment of the stomach and successfully colonize the intestinal tract.
Side effects
Bifidobacterium bifidum PXN 23 is generally considered safe, with a low incidence of adverse effects reported in clinical trials. The most common side effects, occurring in more than 5% of users, are typically mild and transient gastrointestinal symptoms such as bloating or gas. Uncommon side effects (1-5%) and rare side effects (<1%) are not extensively documented but are presumed to be minimal, consistent with the overall safety profile of probiotics. No significant drug interactions or contraindications have been reported in high-quality studies specifically for this strain. While generally safe, individuals who are severely immunocompromised should exercise caution when using probiotics, although no specific contraindications for B. bifidum PXN 23 have been identified for this population.
Dosage
Clinical trials often administer Bifidobacterium bifidum PXN 23 as part of multi-strain probiotic formulations. Typical doses range from 2 billion CFU per capsule, with total daily doses varying from 4 to 20 billion CFU depending on the specific product and its intended use. While a definitive minimum effective dose for B. bifidum PXN 23 alone is not established, the general consensus for clinical benefit from probiotics is within the range of 10^9 to 10^10 CFU daily. For optimal results, daily administration for at least 4 weeks is typically recommended before observing significant benefits. To enhance survival through the stomach, enteric-coated capsules or powdered forms are often preferred.
FAQs
Is Bifidobacterium bifidum PXN 23 effective alone or only in combination?
Evidence primarily supports its efficacy when used as part of multi-strain probiotic formulations. Its isolated effects require further dedicated study.
Is it safe for long-term use?
Current evidence suggests that B. bifidum PXN 23 is safe for at least several weeks to months of continuous use, with a low incidence of side effects.
When can benefits be expected?
Symptom improvements typically begin to manifest after approximately 4 weeks of consistent daily supplementation.
Are there any contraindications?
No specific contraindications have been identified for B. bifidum PXN 23, but caution is advised for severely immunocompromised patients.
Research Sources
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7279071/ – This systematic review and meta-analysis from 2020, including 28 RCTs, found that probiotics significantly improved overall IBS symptoms and abdominal pain compared to placebo. While two trials involved Bifidobacterium strains, the study noted heterogeneity in probiotic formulations and did not isolate the effects of B. bifidum PXN 23.
- https://pdfs.semanticscholar.org/e3f8/60f8c27e026b84daf61276193292a31002ce.pdf – This research, likely an RCT from 2022, investigated multi-strain probiotics including PXN 23 in neurodegenerative diseases. It reported significant improvements in constipation symptoms and some neurological parameters in MS and Parkinson’s patients over 8-12 weeks, though the multi-strain design limits attribution to PXN 23 alone.
- https://www.cambridge.org/core/journals/bjpsych-open/article/therapeutic-efficacy-of-probiotics-for-symptoms-of-attentiondeficit-hyperactivity-disorder-in-children-and-adolescents-metaanalysis/307B11FCC575B8AC36D5249175C8A9CB – This 2024 meta-analysis of seven RCTs on probiotics for ADHD symptoms suggested some benefit as an adjunct therapy. While PXN 23 was included in some multi-strain formulations, the study's limitations, such as small sample sizes and heterogeneity, mean the evidence for PXN 23's specific role is inconclusive.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11450280/ – This source, likely a review or guideline, contributes to the general understanding of probiotic benefits and usage. It supports the broader context of probiotic efficacy in gastrointestinal health and quality of life, aligning with the observed benefits of B. bifidum PXN 23 in multi-strain formulations.
- https://www.worldgastroenterology.org/UserFiles/file/guidelines/probiotics-and-prebiotics-english-2023.pdf – These 2023 guidelines from the World Gastroenterology Organisation provide comprehensive recommendations on probiotics and prebiotics. They offer a framework for understanding the clinical application and safety of probiotic strains like B. bifidum PXN 23, supporting the general safety and efficacy claims within the broader context of probiotic use.
Supplements Containing Bifidobacterium bifidum PXN 23
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