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Bifidobacterium Breve Bbr6o

Also known as: Bifidobacterium breve BBr60, BBr60, Bifidobacterium breve strain BBr60

Overview

Bifidobacterium breve BBr60 is a specific probiotic bacterial strain belonging to the genus Bifidobacterium, naturally found in the human gut microbiota. It is utilized as a dietary supplement to positively modulate gut flora and improve metabolic health. Research primarily focuses on its role in managing metabolic disturbances associated with overweight and obesity, including the regulation of blood glucose, lipid profiles, and liver function markers. While relatively new, studies on BBr60 include well-conducted randomized controlled trials in humans, particularly in overweight or obese young adults. The evidence quality is considered moderate to high, supporting its potential as a beneficial probiotic for metabolic health.

Benefits

Bifidobacterium breve BBr60 has demonstrated several evidence-based benefits, primarily in overweight or obese young adults. The most significant benefit is a reduction in body weight and Body Mass Index (BMI) after 12 weeks of supplementation at 1 × 10^10 CFU/day, showing statistically significant improvements over placebo. It also improves fasting blood glucose levels and lipid metabolism, contributing to an enhanced metabolic profile. Furthermore, BBr60 has been shown to regulate liver function markers, suggesting potential hepatoprotective effects in the context of metabolic syndrome. These benefits are linked to its ability to modulate gut microbiota composition, affecting genera like *Dialister*, *Klebsiella*, and *Bacteroides*, and altering serum and fecal metabolites involved in amino acid and lipid metabolism. The observed effects are clinically significant, with clear improvements in key metabolic parameters, and were consistently noted after 12 weeks of daily supplementation.

How it works

Bifidobacterium breve BBr60 exerts its effects primarily by modulating the composition of the gut microbiota. It increases the abundance of beneficial bacteria while potentially reducing certain pathogenic or dysbiotic genera, which in turn influences host metabolic pathways. Specifically, BBr60 has been shown to alter key metabolic pathways related to amino acid metabolism, including valine, leucine, and isoleucine biosynthesis, as well as glycine, serine, and threonine metabolism. It also impacts lipid metabolism, particularly cholesterol and ascorbate/aldarate pathways. These metabolic changes are believed to lead to improved insulin sensitivity, healthier lipid profiles, and enhanced liver function. Like other *Bifidobacterium* species, BBr60 is thought to transiently colonize the gut, exerting its beneficial effects through the production of various metabolites and by influencing the overall gut environment.

Side effects

Based on available randomized controlled trials, Bifidobacterium breve BBr60 has been reported as safe, with no significant adverse effects observed during 12-week intervention periods. No common or serious side effects were noted in the human studies reviewed. The current literature does not indicate any specific drug interactions or contraindications for BBr60. However, safety in special populations, such as pregnant women, breastfeeding mothers, or immunocompromised individuals, has not been specifically addressed in the published research. As with any probiotic, individuals with severe underlying health conditions or those on immunosuppressive therapy should consult a healthcare professional before use. While generally well-tolerated, individual responses to probiotics can vary, and any unusual symptoms should be reported to a healthcare provider.

Dosage

The effective dosage of Bifidobacterium breve BBr60, as demonstrated in human randomized controlled trials, is 1 × 10^10 Colony Forming Units (CFU) per day. This dosage was administered orally for a duration of 12 weeks to achieve significant metabolic improvements in overweight or obese young adults. Currently, there is no available data on maximum safe doses or established dose-response relationships for BBr60. The research does not specify optimal timing for supplementation (e.g., relative to meals) or any specific form-related recommendations. Similarly, information regarding absorption factors or required cofactors to enhance its efficacy is not detailed in the existing studies. Users should adhere to the recommended dosage and duration as studied.

FAQs

Is BBr60 safe for long-term use?

Current research supports the safety of BBr60 for at least 12 weeks of continuous use. Longer-term safety beyond this period requires further dedicated study.

How quickly can benefits be expected from BBr60?

Significant metabolic improvements, including reductions in weight and BMI, were observed after 12 weeks of consistent daily supplementation with BBr60.

Does BBr60 require dietary control to be effective?

The studies on BBr60 included dietary guidance for participants, suggesting that its benefits may be enhanced when combined with controlled dietary practices and lifestyle measures.

Is BBr60 effective for weight loss alone?

BBr60 has been shown to improve metabolic parameters and reduce BMI. However, it is typically considered part of a broader intervention that includes dietary and lifestyle modifications, rather than a standalone weight loss solution.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC11507383/ – This randomized, double-blind, placebo-controlled trial involving 75 overweight/obese young adults demonstrated that BBr60 significantly reduced body weight, BMI, and fasting glucose after 12 weeks. It also modulated gut microbiota composition and altered serum metabolites, indicating its role in improving metabolic health.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11594036/ – This study, using the same cohort as the previous RCT, provided mechanistic insights through metabolomics analysis. It found that BBr60 regulated 134 serum metabolites, improved cholesterol metabolism, and enhanced liver function, further supporting its metabolic benefits.