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Bifidobacterium breve HRVSD21

Also known as: B. breve, Bifidobacterium breve

Overview

Bifidobacterium breve is a species of probiotic bacteria naturally found in the human gut, particularly in infants, and in breast milk. It is widely utilized as a dietary supplement to promote and maintain gastrointestinal health and support immune system function. Key characteristics include its ability to adhere to intestinal epithelial cells, which is crucial for colonization, and its production of antimicrobial substances that can inhibit the growth of harmful bacteria. Research into B. breve is ongoing, with a moderate level of maturity, exploring its potential benefits in various health conditions, including neurodegenerative diseases. The evidence base, which includes systematic reviews and randomized controlled trials (RCTs), suggests promising applications, though further research is needed to fully understand its comprehensive effects.

Benefits

Bifidobacterium breve offers several evidence-based benefits, primarily in improving gut health and immune function. For preterm infants, there is promising evidence from randomized controlled trials suggesting that B. breve supplementation may reduce the risk of necrotizing enterocolitis (NEC), a severe intestinal condition. In adults, some studies indicate that specific strains, such as B. breve CCFM1025, may improve sleep quality, though more validation is needed for this benefit. While the exact effect sizes vary by study, probiotics like B. breve generally show potential in these areas. Additionally, emerging research suggests potential secondary benefits in neurodegenerative diseases, although this area requires more robust investigation. Benefits can typically manifest within weeks of consistent supplementation, depending on the specific health condition being addressed.

How it works

Bifidobacterium breve primarily exerts its beneficial effects by modulating the gut microbiota composition, promoting a healthier balance of beneficial bacteria. It enhances the intestinal barrier function, which is crucial for preventing the translocation of harmful substances from the gut into the bloodstream. Furthermore, B. breve influences immune responses by interacting with the gastrointestinal and immune systems, likely through the modulation of cytokines and other immune mediators. As a probiotic, it colonizes the gut rather than being absorbed systemically, allowing it to directly interact with the intestinal environment and its resident microbial communities.

Side effects

Bifidobacterium breve is generally considered safe for consumption, with a low incidence of adverse effects. The most commonly reported side effects are mild gastrointestinal disturbances, such as bloating, gas, or abdominal discomfort, which typically resolve with continued use or dosage adjustment. Uncommon side effects have not been consistently reported. In rare instances, there is a theoretical risk of sepsis in severely immunocompromised individuals, although this is extremely rare and primarily a concern in critically ill patients with compromised gut integrity. There are no well-documented drug interactions with B. breve. However, it is generally contraindicated for severely immunocompromised individuals without prior medical supervision. For special populations, B. breve is considered safe for use in preterm infants and is generally well-tolerated in healthy adults.

Dosage

The optimal dosage for Bifidobacterium breve varies depending on the specific product, the strain used, and the health condition being targeted. While a minimum effective dose is not firmly established, typical dosages often range from 10^8 to 10^10 Colony Forming Units (CFU) per serving, often as part of a multi-strain probiotic blend. A maximum safe dose has not been determined, as B. breve is generally considered safe at typical probiotic concentrations. For best results and to enhance its survival through the acidic stomach environment, B. breve supplements are best taken with food. Common forms include capsules or powders. As a probiotic, it colonizes the gut and is not absorbed systemically, so absorption factors are not applicable. No specific cofactors are known to be required for its efficacy.

FAQs

How should I store Bifidobacterium breve supplements?

To maintain the viability of the live bacteria, B. breve supplements should be stored properly, often in a cool, dry place or refrigerated, as indicated on the product label.

Is Bifidobacterium breve safe for everyone?

B. breve is generally safe for most individuals. However, if you are severely immunocompromised, it is crucial to consult a healthcare provider before starting supplementation due to a rare theoretical risk of infection.

When is the best time to take Bifidobacterium breve?

It is generally recommended to take B. breve supplements with meals. This helps to buffer stomach acid, improving the survival rate of the bacteria as they pass through the digestive tract to colonize the gut.

What kind of results can I expect from taking B. breve?

Expected results can vary significantly among individuals and depend on the specific health condition being addressed. Benefits may include improved gut health, better immune function, and potentially enhanced sleep quality, but it is not a 'cure-all'.

Is B. breve a 'cure-all' for digestive issues?

No, B. breve is not a 'cure-all.' While it can significantly support gut health and may alleviate certain digestive issues, its benefits are condition-specific and it should be used as part of a holistic approach to health.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/39940249/ – This systematic review explores the potential of Bifidobacterium breve in improving gut health and its emerging role in neurodegenerative conditions. It highlights the promise of B. breve in modulating the gut-brain axis and suggests that while evidence is growing, more comprehensive research is needed to fully establish its therapeutic applications in neurological disorders.
https://www.mdpi.com/2072-6643/17/3/391 – This study investigates the effects of Bifidobacterium breve on sleep quality. It suggests that specific strains, such as B. breve CCFM1025, may have a positive impact on sleep disturbances, indicating a potential role for this probiotic in improving sleep patterns. Further validation with larger cohorts is recommended.
https://www.webmd.com/vitamins/ai/ingredientmono-1665/bifidobacterium-breve – This source provides a general overview of Bifidobacterium breve, detailing its common uses, potential benefits, and safety profile. It serves as a comprehensive resource for understanding the basic applications and considerations for B. breve supplementation, emphasizing its role in gut health.
https://www.mdpi.com/2072-6643/15/21/4700 – This research focuses on the efficacy of Bifidobacterium breve in reducing the risk of necrotizing enterocolitis (NEC) in preterm infants. It presents findings that support the use of B. breve as a prophylactic measure in this vulnerable population, contributing to improved neonatal outcomes.
https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0150775 – This study explores the broader impact of Bifidobacterium breve on gut microbiota and immune function. It delves into the mechanisms by which B. breve modulates the gut environment and influences systemic immune responses, providing insights into its overall health benefits beyond specific conditions.