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Bifidobacterium breve R0070

Also known as: Bifidobacterium breve R0070, B. breve R0070, Probiotic strain R0070

Overview

*Bifidobacterium breve* R0070 is a Gram-positive, anaerobic bacterium naturally found in the human gut, especially in infants. As a probiotic supplement, it's used to support gut health, modulate immune function, and potentially alleviate gastrointestinal disorders like constipation and IBS. *B. breve* R0070 is known for its ability to colonize the gut and produce beneficial metabolites. Research on *B. breve* as a species is fairly robust, particularly in infants and children, but strain-specific research on R0070 is somewhat limited. Most evidence is extrapolated from related strains. It is available in forms such as capsules and powders.

Benefits

*Bifidobacterium breve* strains have demonstrated efficacy in reducing gastrointestinal symptoms in infants and children, with some RCTs reporting significant improvements in stool frequency and consistency. In animal models, related *B. breve* strains have shown anti-inflammatory effects, such as reduced neutrophil and eosinophil infiltration in asthma models, and increased expression of gut-protective proteins. Emerging evidence suggests potential benefits in neurodegenerative conditions, but this is not specific to R0070 and requires further study. *B. breve* M-16V has reduced the incidence of necrotizing enterocolitis in preterm infants in systematic reviews. In animal models, *B. breve* MRx0004 reduced lung inflammation markers by up to 50% compared to controls.

How it works

*Bifidobacterium breve* R0070 primarily works by enhancing the gut barrier and modulating immune responses. It induces the expression of REGIII-γ, a gut-protective protein, and reduces pro-inflammatory cytokines and chemokines, decreasing neutrophil and eosinophil infiltration in inflammatory models. *B. breve* colonizes the gut, competes with pathogens, and supports mucosal integrity. It modulates both innate and adaptive immune responses. As a probiotic, it is not absorbed systemically and acts locally in the gut; viable bacteria must reach the intestine to exert effects.

Side effects

*Bifidobacterium breve* R0070 is generally recognized as safe (GRAS) for most populations, especially infants and children. Common side effects are rare, with occasional mild gastrointestinal discomfort (bloating, gas) reported. Very rare, no significant adverse events have been reported in clinical trials. Extremely rare, isolated case reports of bacteremia in immunocompromised individuals exist. No significant drug interactions have been reported, but caution is advised in immunocompromised patients. Contraindications include severe immunodeficiency, central venous catheters, or recent surgery. It is considered safe for infants and children, but caution is warranted in immunocompromised adults.

Dosage

While a minimum effective dose is not well-established specifically for R0070, typical doses for *B. breve* range from 1–10 billion CFU/day. This range is considered the optimal dosage for most applications, although higher doses have been used in research settings. There is no established upper limit, and doses up to 50 billion CFU/day have been used in clinical trials without adverse effects. It is best taken with or just before meals to enhance survival through the stomach. Capsules, powders, and fermented foods are common forms. An acid-resistant formulation or food co-administration may be needed to survive gastric transit.

FAQs

How should I store *B. breve* R0070?

Refrigeration is recommended for maximum viability of *B. breve* R0070 supplements. This helps to maintain the number of live bacteria until the product is consumed.

When is the best time to take *B. breve* R0070?

It is recommended to take *B. breve* R0070 with food to improve the survival of the bacteria as it passes through the stomach's acidic environment.

Who should avoid taking *B. breve* R0070?

While generally safe, individuals with severe immunodeficiency should avoid *B. breve* R0070 due to a slightly increased risk of bacteremia.

How long does it take to see results from *B. breve* R0070?

Some individuals may experience improved gut comfort and reduced gastrointestinal symptoms within days to weeks of consistent daily dosing.

Is *B. breve* R0070 a cure-all for gut issues?

No, *B. breve* R0070 is not a cure-all. Its benefits are strain- and condition-specific, and it should be used as part of a comprehensive approach to gut health.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC6265827/ – This review explores the therapeutic potential of *Bifidobacterium breve*, highlighting its role in gut health and immune modulation. It discusses mechanisms such as gut barrier enhancement and anti-inflammatory effects observed in preclinical and clinical studies, suggesting its potential in managing various health conditions.
https://pubmed.ncbi.nlm.nih.gov/28796951/ – This study focuses on the impact of *B. breve* M-16V on preterm infants, demonstrating its effectiveness in reducing the incidence of necrotizing enterocolitis and improving overall gut health. The findings support the use of this probiotic strain in neonatal care to promote better outcomes for vulnerable infants.
https://www.mdpi.com/2072-6643/17/3/391 – This review examines the potential of *Bifidobacterium infantis* and *Bifidobacterium breve* in addressing neurodegenerative diseases. While the evidence is preliminary, it suggests that these probiotics may offer benefits in managing such conditions, warranting further investigation.
https://en.wikipedia.org/wiki/Bifidobacterium_breve – This Wikipedia article provides general information about *Bifidobacterium breve*, including its characteristics, natural sources, and potential health benefits. It serves as a broad overview of the bacterium and its role in the human gut microbiome.
https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2018.00124/full – This article discusses the impact of the gut microbiome on human health and disease, highlighting the role of probiotics like *Bifidobacterium breve*. It explores how these beneficial bacteria can influence immune responses and overall well-being, emphasizing the importance of maintaining a balanced gut ecosystem.