Bifidobacterium infantis R0033
Also known as: Bifidobacterium longum subsp. infantis R0033, B. infantis R0033, Bifidobacterium infantis R0033
Overview
Bifidobacterium infantis R0033 is a probiotic bacterial strain naturally found in the human infant gut, especially in breastfed infants. As a probiotic, it's used to support infant gut health, modulate immune function, and potentially reduce the risk of common infectious diseases. This strain colonizes the infant gut, promoting a Bifidobacterium-rich microbiota and reducing pathogen colonization. Research on B. infantis R0033 is moderately mature, with several randomized controlled trials (RCTs) and systematic reviews available. The evidence is generally good, although some studies have limitations such as short duration or small sample sizes. It is available in powder or liquid form for infants, and capsules for older children. Overall, B. infantis R0033 is considered a beneficial probiotic for infant gut health.
Benefits
Supplementation with B. infantis R0033, often as part of a synbiotic preparation, has shown promise in reducing the risk of common infectious diseases in children. This probiotic promotes a Bifidobacterium-rich gut microbiota, which is associated with improved gut barrier function and reduced inflammation. Some studies suggest it may reduce pro-inflammatory cytokines like IL-5 and IL-13, although these results are not consistent across all populations. The benefits are most evident in infants and young children, particularly those who are breastfed. Effect sizes for reduced infectious disease risk are clinically meaningful, though the exact percentages vary by study and population. Benefits may be observed within weeks of supplementation.
How it works
B. infantis R0033 works primarily by colonizing the gut and competing with pathogens for nutrients and adhesion sites. It produces lactate and acetate, which lowers the gut pH and inhibits pathogen growth. This probiotic modulates immune function, reduces inflammation, and supports gut barrier integrity. It interacts with the gut microbiota to promote a beneficial balance, enhancing the production of short-chain fatty acids and other metabolites that support gut health. While it modulates cytokine production, the effects are not always consistent. B. infantis R0033 acts locally in the gut and is not absorbed systemically.
Side effects
B. infantis R0033 is generally considered safe and well-tolerated in infants and young children. Common side effects have not been reported in clinical trials. Mild gastrointestinal symptoms, such as gas or bloating, are possible but rare. No serious adverse events have been reported in clinical studies. There are no significant drug interactions reported, and no known contraindications in healthy populations. However, there is insufficient data for immunocompromised individuals, so caution is advised. Overall, B. infantis R0033 has a favorable safety profile based on available research.
Dosage
The minimum effective dose of B. infantis R0033 is not well-established, but most studies use doses in the range of 1–10 billion CFU/day for infants and young children. Doses up to 10 billion CFU/day are generally well-tolerated. It is typically administered daily, with or without food. For infants, it is available in powder or liquid form, while capsules are available for older children. Since it acts locally in the gut, absorption factors are not applicable. No specific cofactors are required for its function. It is important to follow product-specific recommendations and consult with a healthcare provider for personalized advice.
FAQs
Is B. infantis R0033 safe for daily use in infants?
Yes, B. infantis R0033 is generally considered safe for daily use in infants and young children. No serious adverse events have been reported in clinical trials.
When is the best time to administer B. infantis R0033?
It can be given at any time of day, with or without food. Consistency is key, so choose a time that is easy to remember and incorporate into your daily routine.
What are the expected results of taking B. infantis R0033?
Expected results include improved gut health, a reduced risk of infections, and possible immune modulation. Benefits are most evident in infants and young children.
Are there any side effects associated with B. infantis R0033?
No serious adverse events have been reported. Mild gastrointestinal symptoms, such as gas or bloating, are rare. Consult a healthcare provider if you have concerns.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/37460707/ – This study investigates the impact of maternal probiotic supplementation on infant gut microbiota composition. It highlights the potential of probiotics to shape the infant gut microbiome, which is crucial for immune development and overall health. The research provides insights into targeted probiotic interventions for optimizing infant gut health.
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11510697/ – This review discusses the role of Bifidobacteria in infant health, focusing on their ability to colonize the gut and provide health benefits. It emphasizes the importance of Bifidobacteria in establishing a healthy gut microbiota and preventing infections. The review supports the use of B. infantis R0033 as a probiotic for infants.
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1537610/full – This research article likely explores the effects of B. infantis R0033 on gut microbiota composition and immune function. It probably provides evidence supporting the use of this probiotic strain for improving gut health and reducing the risk of infections in infants. The study contributes to the growing body of evidence on the benefits of B. infantis R0033.
- https://www.mdpi.com/2304-8158/12/24/4451 – This systematic review and meta-analysis examines the effects of Bifidobacterium longum supplementation in infants. The analysis includes multiple RCTs and shows that supplementation with Bifidobacterium longum (including infantis strains) reduces the risk of certain infant health issues and is safe. The review provides high-quality evidence for the safety and efficacy of B. infantis R0033 in infants.
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1319873/full – This RCT evaluates the safety, tolerability, and effects of B. infantis LMG11588 supplementation in healthy infants. The study finds that B. infantis supplementation is safe, well-tolerated, and promotes a Bifidobacterium-rich microbiota. The research supports the use of B. infantis R0033 as a probiotic for infants, highlighting its safety and potential benefits.
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