Bifidobacterium lactis B104
Also known as: Bifidobacterium lactis, B. lactis, B. animalis subsp. lactis, Bifidobacterium B104, Bifidobacterium animalis subsp. lactis
Overview
Bifidobacterium animalis subsp. lactis is a Gram-positive, anaerobic bacterium naturally found in the human gut and fermented dairy products. It is a well-studied probiotic supplement used primarily to support gastrointestinal health and modulate immune function. Research suggests potential benefits for improving skin health, though evidence is less robust. This probiotic is characterized by its safety and efficacy, particularly in addressing gastrointestinal issues. It works by modulating the gut microbiota composition, enhancing gut barrier function, reducing pro-inflammatory cytokines, and stimulating immune cell activity. Available in various forms, including capsules, powders, and fermented foods, Bifidobacterium lactis is a common choice for individuals seeking to improve their gut health and overall well-being. The strain B104 is a proprietary designation and may not be widely indexed, but the research on the subspecies applies.
Benefits
Bifidobacterium animalis subsp. lactis has demonstrated benefits primarily in gastrointestinal health. A 2022 meta-analysis showed a small to moderate reduction in gastrointestinal symptoms such as abdominal pain and bloating (SMD -0.2 to -0.4). Some evidence suggests potential immune modulation, but the data are less conclusive. Limited research indicates possible benefits for skin hydration and barrier function, but these findings are preliminary. Meta-analyses show no significant effect on reducing dental caries or Streptococcus mutans counts in saliva. It is generally well-tolerated and safe for infants and children, with some evidence supporting gastrointestinal and immune benefits in these populations. Benefits may be observed within 2–4 weeks of supplementation.
How it works
Bifidobacterium animalis subsp. lactis primarily works by modulating the gut microbiota composition, enhancing gut barrier function, reducing pro-inflammatory cytokines, and stimulating immune cell activity. It interacts with the gastrointestinal and immune systems, targeting Toll-like receptors (TLRs), cytokines (such as IL-10 and TNF-α), and gut epithelial tight junction proteins. As a probiotic, it is not absorbed systemically but acts locally within the gut. By influencing the balance of gut bacteria and strengthening the intestinal barrier, it helps to reduce inflammation and improve overall gut health.
Side effects
Bifidobacterium animalis subsp. lactis is generally recognized as safe (GRAS) for most populations. Common side effects, affecting more than 5% of users, include mild gastrointestinal discomfort such as bloating and gas. Uncommon side effects, reported in 1-5% of users, include rare instances of mild diarrhea or constipation. Serious adverse events are rare, with no significant interactions reported. Contraindications are limited, with caution advised for individuals with severe immunocompromise due to theoretical risks. It is considered safe for infants and children. Overall, the safety profile of Bifidobacterium lactis is well-established, with minimal risks for the majority of users.
Dosage
The minimum effective dose of Bifidobacterium animalis subsp. lactis is 1–5 billion CFU/day for gastrointestinal benefits. Optimal dosage ranges are typically between 5–10 billion CFU/day, as used in most studies. Clinical trials have safely used up to 50 billion CFU/day. It can be taken with or without food, though taking it with a meal may improve its survival through the stomach's acidic environment. Available in capsules, powders, and fermented foods, the effectiveness depends on live bacteria reaching the gut. No specific cofactors are required for its function.
FAQs
Is Bifidobacterium lactis safe?
It is safe for most, including children and the elderly. Caution is advised for severely immunocompromised individuals due to theoretical risks.
When is the best time to take it?
It is best taken with a meal to enhance survival through gastric acid, ensuring more bacteria reach the gut.
How long before I see results?
Modest improvements in gastrointestinal symptoms may be observed within 2–4 weeks of consistent supplementation.
Is it a cure for GI diseases?
No, it is not a cure for serious gastrointestinal diseases. Benefits are modest and may vary by individual.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/34918142/ – This systematic review and meta-analysis examined the effects of Bifidobacterium animalis subsp. lactis supplementation on gastrointestinal symptoms in adults. The analysis of multiple RCTs found a statistically significant reduction in gastrointestinal symptoms, with standardized mean differences ranging from -0.2 to -0.4, indicating a small to moderate benefit. The review highlights the potential of this probiotic in managing common gastrointestinal issues.
- https://www.webmd.com/vitamins/ai/ingredientmono-891/bifidobacterium-animalis-subsp-lactis – WebMD provides general information on Bifidobacterium animalis subsp. lactis, outlining its uses, effectiveness, and potential side effects. It serves as a consumer-friendly resource for understanding the basics of this probiotic and its role in health.
- https://www.mdpi.com/2673-6179/2/2/5 – This MDPI article discusses the potential benefits of Bifidobacterium animalis subsp. lactis, focusing on its mechanisms of action and clinical applications. It provides insights into how this probiotic interacts with the gut microbiota and immune system, contributing to overall health.
- https://www.mdpi.com/2076-2607/11/10/2501 – This review focuses on the safety and tolerability of Bifidobacterium animalis subsp. lactis in infants and children. It highlights that the probiotic is generally well-tolerated and safe for pediatric populations, with some evidence supporting gastrointestinal and immune benefits. The review underscores the importance of safety considerations in probiotic use for young children.
- https://medicaljournalssweden.se/actaodontologica/article/download/36185/41312/93650 – This systematic review and meta-analysis investigated the effects of Bifidobacterium animalis subsp. lactis on oral health, specifically dental caries and Streptococcus mutans counts. The analysis found no significant effect on either outcome, suggesting limited benefits for oral health. The study's findings indicate that this probiotic may not be effective in preventing dental caries or reducing S. mutans levels in saliva.
Supplements Containing Bifidobacterium lactis B104
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