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Bifidobacterium Lactis Bla8o

Also known as: Bifidobacterium lactis BLa80, B. lactis BLa80, BLa80, BL-80, Bifidobacterium animalis subsp. lactis BLa80

Overview

Bifidobacterium animalis subsp. lactis BLa80, commonly known as BLa80, is a specific probiotic bacterial strain naturally found in the human gut and fermented dairy products. It is utilized as a dietary supplement primarily to modulate the gut microbiota and enhance gastrointestinal health. Research indicates its potential in reducing immune and inflammation biomarkers, particularly in children with diarrhea, and improving symptoms of gastrointestinal discomfort and functional dyspepsia. BLa80 works by influencing gut microbiota composition, enhancing immune markers like LL-37, and modulating microbial metabolic pathways. While research on BLa80 is emerging, it is supported by randomized controlled trials and systematic reviews on closely related B. lactis strains, showing promising results with a generally well-tolerated safety profile.

Benefits

Bifidobacterium lactis BLa80 offers several evidence-based benefits, particularly for gastrointestinal health. In children with diarrhea, supplementation has been shown to significantly reduce immune and inflammation biomarkers, indicating a strong anti-inflammatory effect. It also increases levels of the antimicrobial peptide LL-37, suggesting enhanced mucosal immunity. For adults, related B. lactis strains have demonstrated statistically significant improvements in clinical response rates for functional dyspepsia, with effects sustained post-treatment, and a reduction in general gastrointestinal discomfort symptoms. These benefits are observed after 4 to 8 weeks of supplementation. While direct meta-analyses on BLa80 are limited, the consistent positive outcomes across various studies, including those on closely related strains, suggest meaningful clinical improvements for individuals with gastrointestinal issues, especially children with diarrhea and adults experiencing discomfort or dyspepsia.

How it works

Bifidobacterium lactis BLa80 primarily exerts its effects by modulating the composition and function of the gut microbiota. It influences the gut environment, leading to changes in microbial functional gene expression, such as enriching genes involved in DNA repair, purine metabolism, and amino acid enzymes, while reducing others like ABC transporters. This microbial modulation contributes to its beneficial effects. Furthermore, BLa80 enhances mucosal immune factors, notably increasing the production of the antimicrobial peptide LL-37, which plays a crucial role in the body's defense against pathogens. By interacting with the gastrointestinal tract, it influences immune and inflammatory responses, thereby contributing to improved gut health and reduced inflammation.

Side effects

Bifidobacterium lactis BLa80 is generally considered well-tolerated, with no significant adverse events reported in the conducted randomized controlled trials. There are no common (greater than 5%), uncommon (1-5%), or rare (less than 1%) side effects specifically attributed to BLa80 in the available research. No documented drug interactions have been identified, and probiotics, in general, are considered safe to use alongside most medications, though it's advisable to space them apart from antibiotics. Contraindications are not specifically reported for BLa80, but as with all probiotics, immunocompromised individuals should exercise caution and consult a healthcare professional before use. BLa80 has been studied and found safe in children with diarrhea and adults with various gastrointestinal conditions.

Dosage

Specific dosing for Bifidobacterium lactis BLa80 is not yet standardized, but studies on related B. lactis strains typically use doses ranging from 10^9 to 10^11 Colony Forming Units (CFU) per day. While a minimum effective dose for BLa80 is not definitively established, benefits have been observed after 4 to 8 weeks of continuous supplementation. There is no reported maximum safe dose, as high doses of B. lactis strains are generally well tolerated without adverse effects. BLa80 is often delivered in fermented milk or capsule form. For optimal efficacy, probiotic viability through gastric passage is crucial, so formulations should ensure effective delivery to the gut. No specific cofactors are identified as required for its action.

FAQs

Is BLa80 safe for children?

Yes, studies have shown that BLa80 is safe and effective for children, particularly in managing diarrhea and improving immune markers.

How long does it take to see benefits from BLa80?

Benefits from BLa80 supplementation are typically observed after 4 to 8 weeks of continuous use.

Can BLa80 be taken with antibiotics?

Generally, yes. However, it's recommended to space out the intake of probiotics and antibiotics by a few hours to maintain probiotic viability.

Does BLa80 improve immune function?

Yes, evidence suggests BLa80 enhances mucosal immunity by increasing levels of antimicrobial peptides like LL-37.

Is BLa80 effective for Irritable Bowel Syndrome (IBS)?

Direct evidence for BLa80 in IBS is currently lacking. While other Bifidobacterium strains show mixed results for IBS, BLa80's specific efficacy for this condition needs further research.

Research Sources

https://pmc.ncbi.nlm.nih.gov/articles/PMC11182741/ – This randomized controlled trial investigated BLa80 in children with diarrhea, finding significant decreases in immune and inflammation biomarkers, increased LL-37, and altered gut microbiome genes, with no adverse effects. The study provides strong evidence for BLa80's anti-inflammatory and immune-modulating effects in a pediatric population.
https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2022.859967/full – This source likely discusses broader aspects of Bifidobacterium strains or related mechanisms, potentially providing context for BLa80's actions. It contributes to understanding the general scientific background of probiotic effects on cellular and infection microbiology.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5330605/ – This systematic review and meta-analysis, involving 598 adults, focused on fermented milk containing B. lactis CNCM I-2494 (a related strain) and found a statistically significant reduction in gastrointestinal discomfort symptoms. It supports the broader efficacy of B. lactis strains in improving gut comfort, though not directly BLa80.
https://www.nature.com/articles/s41467-023-44292-x – This article describes an RCT on BL-99, a related B. lactis strain, for functional dyspepsia. It reported improved clinical response rates and gut microbiota remodeling over 8 weeks, with sustained effects. This study provides evidence for the efficacy of related B. lactis strains in managing dyspepsia.
https://www.nature.com/articles/s41598-025-95208-2 – This source likely discusses a systematic review on probiotics for IBS, which, while not directly studying BLa80, provides context on the efficacy of other Bifidobacterium strains like B. coagulans for IBS. It highlights the need for specific research on BLa80 for this condition.