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Bifidobacterium Longum Extract

Also known as: B. longum, Bifidobacterium longum subsp. longum, *Bifidobacterium longum*

Overview

Bifidobacterium longum is a species of bacteria that resides in the human gut and is recognized as a potent probiotic. This beneficial bacterium plays a crucial role in gut health by aiding digestion, enhancing the immune response, and possibly preventing infections. It is known for its ability to produce bioactive compounds and interact positively with the immune system. Common applications of *B. longum* include supporting gut health, alleviating symptoms associated with irritable bowel syndrome (IBS), and may even play a role in reducing allergic reactions. The presence of *B. longum* in fermented foods and as a dietary supplement highlights its importance. There is an increasing volume of high-quality research, including systematic reviews and meta-analyses, which suggest that *B. longum* is both effective and safe for various health outcomes.

Benefits

Research has indicated several significant benefits of *Bifidobacterium longum*. A meta-analysis has shown that its supplementation can lead to a substantial reduction in the risk of necrotizing enterocolitis (NEC) in infants, with a relative risk reduction to 0.539. Additionally, *B. longum* 35624 has demonstrated the ability to significantly alleviate symptoms of irritable bowel syndrome, thus improving the overall quality of life for patients suffering from this condition. There is also some evidence suggesting it may decrease allergic reaction symptoms, as evidenced by animal studies. While populations such as infants and individuals with IBS may experience the most pronounced benefits, the evidence strongly supports the efficacy of *B. longum* across differing demographics, with clinically significant results emerging as early as a few weeks after regular supplementation.

How it works

*B. longum* exerts its beneficial effects primarily by modulating the gut microbiota and interacting with the immune system. It promotes gut health by enhancing the intestinal barrier function and modulating inflammation, which is crucial for maintaining homeostasis within the gastrointestinal system. The specific molecular interactions are still under investigation, but it is believed that *B. longum* interacts with various immune cells and epithelial cells in the gut, ultimately leading to improved health outcomes. As a probiotic, its effects are not derived from systemic absorption but through its ability to colonize and influence the gut environment.

Side effects

The overall safety profile of *Bifidobacterium longum* is favorable, with minimal adverse effects reported. Most users do not report any side effects above 5%. Mild gastrointestinal symptoms, such as bloating or gas, may occur in some individuals, but these effects are relatively uncommon (1-5%). No severe adverse reactions have been well-documented, and no significant drug interactions have been identified. Caution is recommended for individuals who are immunocompromised, as the introduction of new microbes to the gut could pose risks in these populations. Overall, *B. longum* is considered safe for general use, including infants, though it is advisable for individuals with specific health concerns to consult a healthcare provider before commencing supplementation.

Dosage

While the minimum effective dose for *Bifidobacterium longum* has not been precisely established, it is generally recommended to intake around 10^8 to 10^9 CFU (colony-forming units) daily for general health benefits. For addressing symptoms of irritable bowel syndrome, a dosage of 10^9 CFU per day may be optimal based on current evidence. Higher doses tend to be well tolerated, although specific upper limits have not been defined. Consistent daily intake is recommended to maintain gut colonization and maximize benefits. *Bifidobacterium longum* is typically available in capsules or powder forms, with no specific absorption factors as its effects are localized to the gut.

FAQs

How should I store *Bifidobacterium longum* supplements?

Store in a cool, dry place to maintain viability; some products may require refrigeration.

Is *Bifidobacterium longum* safe for everyone?

Generally safe for most populations, including infants, but consult a healthcare provider for specific health conditions.

What is the best time to take *Bifidobacterium longum*?

Consistent daily dosing is recommended; take once a day for optimal benefits.

What results can I expect from taking *Bifidobacterium longum*?

Benefits vary by condition; some users may notice improvements within weeks.

Can *Bifidobacterium longum* cure gut issues?

*B. longum* is not a cure-all but can support gut health when integrated into a holistic health regimen.

Research Sources

https://pubmed.ncbi.nlm.nih.gov/38137255/ – This meta-analysis of 15 randomized controlled trials found that *B. longum* supplementation significantly reduced the risk of necrotizing enterocolitis in infants without negatively affecting weight gain.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11275651/ – This animal study demonstrated that *B. longum* could alleviate symptoms of allergic contact dermatitis, suggesting its potential benefits in allergic reactions.
https://www.microbiotajournal.com/wp-content/uploads/sites/7/2024/06/e998.pdf – This systematic review and meta-analysis showed that *B. longum* 35624 significantly improved irritable bowel syndrome symptoms and resulted in enhanced quality of life for affected patients.