Bifidobacterium Longum Infantis Mak22b04i
Also known as: *Bifidobacterium infantis*, *B. infantis*, Mak22b04i, *Bifidobacterium longum* subsp. *infantis*
Overview
*Bifidobacterium longum* subsp. *infantis* is a beneficial probiotic bacterium commonly residing in the gut microbiota of breastfed infants. It is primarily extracted as a probiotic supplement aimed at promoting gut health, immune function, and digestion. This subspecies has the remarkable ability to digest human milk oligosaccharides, which are critical for maintaining a balanced gut microbiome. Research on *B. infantis* emphasizes its important role in reducing the incidence of gastrointestinal disorders, such as diarrhea and necrotizing enterocolitis (NEC), especially in vulnerable populations like infants. The current body of evidence surrounding this strain is of moderate to high maturity, supported by systematic reviews and meta-analyses that validate its health benefits.
Benefits
Research supports several significant benefits of *B. infantis*, particularly in infants. A meta-analysis has shown that the use of this probiotic can significantly lower the risk of necrotizing enterocolitis (NEC) in infants. Additionally, randomized controlled trials (RCTs) indicate that supplementation with *B. infantis* can lead to a reduction in diarrhea episodes by approximately 8 weeks in infants. This strain demonstrates its efficacy in promoting gut health and overall well-being, especially in preterm infants where it has been found to specifically decrease the incidences of NEC, sepsis, and related mortality. The evidence supporting these outcomes shows significant clinical relevance, primarily within populations prone to gastrointestinal complications.
How it works
*Bifidobacterium longum* subsp. *infantis* operates mainly through its interaction with human milk oligosaccharides, which serve as a food source and promote its growth within the gut microbiome. This probiotic enhances gut health by stimulating the growth of beneficial gut bacteria, helping to restore balance to the intestinal microenvironment. It also strengthens intestinal barrier function, thereby preventing pathogen translocation and bolstering immune responses against gastrointestinal disorders.
Side effects
The safety profile for *Bifidobacterium longum* subsp. *infantis* is generally robust, with limited side effects reported across various studies. Common side effects, occurring in more than 5% of users, have not been consistently documented. Mild gastrointestinal symptoms may arise, though they typically occur in less than 5% of cases. Rare adverse effects are noted but are not commonly reported. There are no significant drug interactions associated with this probiotic. However, caution is warranted for immunocompromised individuals regarding its use, as underlying conditions may influence efficacy and safety.
Dosage
The minimum effective dose of *Bifidobacterium longum* subsp. *infantis* is typically in the range of 10^7 CFU/g. Optimal doses can vary based on specific health objectives and product formulations, but common ranges generally fall between 10^9 to 10^10 CFU per day for infants. It's advisable to administer the probiotic along with food to improve its survival through the digestive tract. Though there are no definitive upper dosage limits established, safety is frequently maintained at standard probiotic levels, aligning with typical microbial dosing guidelines.
FAQs
Is *Bifidobacterium longum* subsp. *infantis* safe for infants?
Yes, it is considered safe for use in infants, including preterm infants. Always consult with a healthcare provider for specific advice.
When is the best time to take *B. infantis*?
It is best taken with meals to enhance probiotic survival through the digestive system.
How quickly can I expect to see results from *B. infantis*?
Benefits like reduced diarrhea and NEC risk can typically be observed within a few weeks of consistent supplementation.
Is *B. infantis* a cure for all digestive issues?
No, while beneficial, it is not a universal solution for all digestive problems; individual responses may vary.
Research Sources
- https://pubmed.ncbi.nlm.nih.gov/38137255/ – This meta-analysis evaluated the effects of *Bifidobacterium longum* on necrotizing enterocolitis among infants. It found that probiotic supplementation significantly reduces the risk of NEC, indicating its potential benefits for vulnerable populations.
- https://pubmed.ncbi.nlm.nih.gov/29538368/ – This RCT demonstrated that *B. infantis* supplementation reduced diarrhea episodes in infants over an 8-week period. The study highlights its effectiveness in promoting gastrointestinal health.
- https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1194945/full – A systematic review and meta-analysis that covered several studies involving preterm infants suggested that probiotics with *B. infantis* could significantly reduce incidences of NEC, sepsis, and mortality rates.
- https://www.researchgate.net/publication/305622954_Dietary_supplementation_with_Bifidobacterium_longum_subsp_infantis_B_infantis_in_healthy_breastfed_infants_Study_protocol_for_a_randomised_controlled_trial – This study protocol outlines the methodology for investigating *Bifidobacterium longum* in healthy infants, emphasizing the role of probiotics in gut health and development.
- https://pubmed.ncbi.nlm.nih.gov/37460707/ – A comprehensive analysis detailing the role of probiotics in early life, specifically focusing on *B. infantis* and its implications for gut health and developmental outcomes in infants.
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